Selectivity and potency of 2‐alkyl analogues of the α2‐adrenoceptor antagonist idazoxan (RX 781094) in peripheral systems

British Journal of Pharmacology

Volumn 83, Issue 3, 1984, Pages 713-722

  Doxey, J C ^a   Roach, A G ^a   Strachan, Diane A ^a   Virdee, Narinder K ^a  

^a Pharmaceutical Division ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 ETHYL 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 (2 METHYL 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 (2 PROPYL 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ATROPINE; BRIMONIDINE; CIRAZOLINE; COCAINE; CORTICOSTERONE; GUANABENZ; IDAZOXAN; NORADRENALIN; PROPRANOLOL; UNCLASSIFIED DRUG; YOHIMBINE;

2 (2 ETHYL 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 (2 IMIDAZOLIN 2 YL) 2 ISOPROPYL 1,4 BENZODIOXAN; 2 (2 METHYL 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 (2 PROPYL 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ANIMAL CELL; AUTONOMIC NERVOUS SYSTEM; DRUG POTENCY; GUINEA PIG; IDAZOXAN DERIVATIVE; LARGE INTESTINE; MALE GENITAL SYSTEM; MUSCLE; NONHUMAN; PHARMACOLOGY; PRIORITY JOURNAL; SMOOTH MUSCLE;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMAL; BLOOD PRESSURE; DIOXANES; DIOXINS; ELECTRIC STIMULATION; HEART RATE; IDAZOXAN; IN VITRO; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MUSCLES; RATS; RATS, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS; YOHIMBINE;

EID: 0021684596     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1984.tb16225.x     Document Type: Article

References (14)

1. Some quantitative uses of drug antagonists
2. 2‐agonist for the characterization of α‐adrenoceptor subtypes
3. Functional and biochemical evidence for the lack of cardiac presynaptic alpha‐2 adrenoceptor stimulatory properties of cirazoline (LD 3098), a potent alpha‐1 adrenoceptor agonist in dogs and rats
4. 2‐adrenoceptor antagonist
5. Comparison of pre‐ and post‐junctional potencies of several alpha‐adrenoceptor agonists in the cardiovascular system and anococcygeus muscle of the rat
6. Profiles of α‐adrenoceptor antagonists in the pithed rat
7. Inhibitory effects of clonidine on responses to sympthetic nerve stimulation in the pithed rat
8. Comparison of the α‐adrenoceptor antagonist profile of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine
9. 2‐adrenoceptors
10. 2‐adrenoceptors
11. 2‐adrenoceptors in the rat
12. 2‐adrenoceptor antagonists in the pithed rat preparation
13. 2‐adrenoceptor antagonist, in pithed rats
14. Selectivity of some α‐adrenoceptor agonists for peripheral alpha‐1 and alpha‐2 adrenoceptors in the normotensive rat