Mechanism of reduction of action potential duration of ventricular myocardium by exogenous lactate

Journal of Molecular and Cellular Cardiology

Volumn 16, Issue 7, 1984, Pages 659-662

  Saman, S ^a   Opie, L H ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Action potential duration; Glycolysis; Lactate

Indexed keywords

LACTIC ACID;

ACTION POTENTIAL; ANIMAL CELL; GLYCOLYSIS; GUINEA PIG; HEART; HEART MUSCLE; HEART PAPILLARY MUSCLE; NONHUMAN; NORMAL VALUE; PRIORITY JOURNAL;

ACTION POTENTIALS; ANIMAL; CORONARY DISEASE; DEOXYGLUCOSE; GLUCOSE; GLYCOGEN; GLYCOLYSIS; GUINEA PIGS; LACTATES; LACTIC ACID; MANNITOL; PAPILLARY MUSCLES; SUPPORT, NON-U.S. GOV'T;

EID: 0021630280     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2828(84)80629-X     Document Type: Article

References (15)

1. Control of ionic permeabilities in normal and ischaemic hearts
2. The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart
3. Electrophysiological effects of lactate in mammalian ventricular tissue
4. Characteristics and possible mechanism of ventricular arrhythmias dependent on the dispersion of action potential durations
5. Effects of increased heart work on glycolysis and adenine nucleotides in the perfused heart of normal and diabetic rats
6. Biochemical aspects of arrhythmogenesis and ventricular fibrillation
7. Influence of glucose on the transmembrane action potential of guinea-pig papillary muscle
8. Mechanisms of glycolytic inhibition in ischaemic rat hearts
9. Comparison of the effects of anoxia and whole heart ischaemia on carbohydrate utilization in isolated working rat hearts
10. Early ventricular arrhythmias: relationship of electrophysiology to blood flow and metabolism
11. Combined electrophysiological techniques for assessment of cellular basis of ventricular arrhythmias. Experiments in dogs
12. Modification of the cardiac action potential by intracellular injection of adenosine triphosphate and related substances in guinea pig single ventricular cells
13. Localization of the primary metabolic block produced by 2-deoxyglucose
14. The effect of excess lactate upon the excitability of the sheep Purkinje fibre
15. Excess lactate modulates ionic currents and tension components in frog atrial muscle