Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of langerhans

Endocrine Reviews

Volumn 5, Issue 3, 1984, Pages 411-434

  Lenzen, Sigurd ^a   Bailey, Clifford J ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; ESTROGEN; GLUCAGON; INSULIN; ORAL CONTRACEPTIVE AGENT; PROGESTERONE; SEX HORMONE; THYROID HORMONE;

ANIMAL; BIOLOGICAL MODEL; BLOOD; DIABETES MELLITUS; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HISTOLOGY; HOMEOSTASIS; HUMAN; METABOLISM; PANCREAS ISLET; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; REVIEW;

ADRENAL CORTEX HORMONES; ANIMAL; BLOOD GLUCOSE; CONTRACEPTIVES, ORAL; DIABETES MELLITUS; ESTROGENS; FEMALE; GLUCAGON; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMAN; INSULIN; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; PREGNANCY; PROGESTERONE; SEX HORMONES; THYROID HORMONES;

EID: 0021437995     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-5-3-411     Document Type: Article

References (345)

1. Dumontpallier 1867 Goître exophthalmique et glycosurie chez la même malade. C R Soc Biol 4:116
2. Lenzen S 1979 Schilddrüsenhormone und Funktion des endokrinen Pankreas. Habilitationsschrift, Göttingen
3. Sattler H 1909 Die Basedow sehe Krankheit. Wilhelm Engelmann Verlag, Leipzig, p 379
4. Wilder RM 1926 Hyperthyroidism, myxedema and diabetes. Arch Intern Med 38:736
5. Joslin EP, Lahey FH 1928 Diabetes and hyperthyroidism. Am J Med Sei 176:1
6. Andrus EC 1932 Hyperthyroidism and diabetes mellitus. Bull Johns Hopkins Hosp 50:383
7. John HJ 1932 Hyperthyroidism showing carbohydrate metabolism disturbances. J Am Med Ass 99:620
8. Foster DP, Lowrie WL 1938 Diabetes mellitus associated with hyperthyroidism. Endocrinology 23:681
9. Regan JF, Wilder RM 1940 Hyperthyroidism and diabetes. Arch Intern Med 65:1116
10. Kellen J 1956 Über Störungen des Kohlenhydratstoffwechsels bei erhöhter Tätigkeit der Schilddrüse. Z Inn Med 11:368
11. Perlman LV 1961 Familial incidence of diabetes in hyperthyroidism. Ann Intern Med 55:796
12. James WD 1894 Glycosuria from taking thyroid extract. Br J Dermatol 6:177
13. Grawitz E 1897 Morbus Basedowii, complicirt mit Diabetes mellitus; nebst Bemerkungen über Jodthyrinwirkung. Fortschr. Med 15:849
14. Stern H 1902 The association of Graves’ disease with glycosuria and diabetes mellitus. J Am Med Ass 39:972
15. Falta W, Newburgh LH, Nobel E 1911 Über die Wechselwirkung der Drüsen mit innerer Sekretion. IV. Mitteilung. Über Beziehungen der Überfunktion zur Konstitution. Z Klin Med 72:97
16. Rohdenburg GL 1920 Thyroid diabetes. Endocrinology 4:63
17. John HJ 1927 Carbohydrate metabolism in hyperthyroidism. Endocrinology 11:497
18. Troell A, Tyrenius H, Olovson T 1931 Rubbningar i kolhydratomsättningen vid toxisk struma. Hygiea 93:130
19. Andersen WT 1933 Studies on blood sugar and glycosuria in exophthalmic goitre. Acta Med Scand 54:1
20. Joslin EP, Lahey FH 1934 Diabetes and hyperthyroidism. Ann Surg 100:629
21. Rowe AW 1935 The metabolism of galactose. III. The influence of disturbed endocrine function. Am J Med Sei 190:686
22. Hirschl JA 1902 Beiträge zur Kenntnis des Morbus Basedowii. Die alimentäre Glykosurie beim Morbus Basedowii. Jahrb Psychiatr Neurol 22:197
23. Falta W 1910 Über Glykosurie und Fettstühle bei Morbus Basedowii; zugleich ein Beitrag zur Röntgentherapie dieser Krankheit. Z Klin Med 71:1
24. Allen FM 1922 Experimental studies in diabetes. Series II. The intestinal pancreatic function in relation to body mass and metabolism. 10. The influence of the thyroid upon diabetes. J Metab Res 1:619
25. Baranoff WG 1928 Über den Einfluß der Schilddrüse auf die Entwicklung und den Verlauf des Diabetes. Z Exp Med 59:222
26. Houssay BA 1946 The thyroid and diabetes. Vitam Horm 4:187
27. Houssay BA, Foglia VG, Martinez C 1946 The influence of the thyroid on alloxan and pancreatic diabetes in the rat. Endocrinology 39:361
28. Houssay BA 1948 The action of the thyroid on diabetes. Recent Prog Horm Res 2:277
29. Shpiner LP 1930 Increased metabolism only one factor in the production and maintenance of the hyperglycemia and glycosuria in experimental hyperthyroidism. Am J Physiol 92:672
30. Molander DW, Kirschbaum A 1949 Hyperglycemia and glucosuria following thyroid administration in alloxan treated rats. J Lab Clin Med 34:492
31. MacCullum WG 1909 On the relation of the islands of Langerhans to glycosuria. Bull Johns Hopkins Hosp 20:265
32. Massaglia A 1915 Beitrag zur Kenntnis der Pathogenese des Diabetes mellitus. Centralbl Allg Pathol 26:65
33. Friedman GA, Gottesman J 1923 The thyroid factor in pancreatic diabetes. An experimental study. Proc N Y Pathol Soc 22:211
34. Wolfson H 1927 On the alleged antagonistic action of the intestinal secretions of the pancreas and the thyroid. Am J Physiol 81:453
35. Yriart M 1930 Thyroidectomie et diabète pancréatique. C R Soc Biol 105:128
36. Neal WB, Dragstedt LR, Rogers GR, McKeague G 1952 Effect of destruction of thyroid glands by radioactive iodine on pancreatic diabetes in dog. Am J Phyiol 168:29
37. Lenzen S, Kücking H 1982 Inhibition of insulin secretion by Lthyroxine and D-thyroxine treatment in rats under the influence of drugs affecting the adrenergic nervous system. Acta Endocrinol 100:527
38. Mark RE 1926 Hyperthyreoidisationsversuche an Hunden. III. Mitteilung. Schilddrüse und Kohlenhydrattoleranz. Pfluegers Arch 211:523
39. Renauld A, Pinto JEB, Sverdlik RC, Foglia VG 1971 Studies on the effect of hyperthyroidism on the insulin response to hyperglycemia in the dog. Horm Metab Res 3:247
40. Orsetti A, Collard F, Jaffiol C 1974 Abnormalities of carbohydrate metabolism in experimental and clinical hyperthyroidism: studies on plasma insulin and on the Aand B-chains of insulin. Acta Diabetol Lat 11:486
41. Marks HP 1925 Effect of thyroid feeding on sugar tolerance. J Physiol 60:402
42. Orsetti A, Basseres J, Macabies J 1970 L’insulinosécrétion chez le chien en état de déséquilibre thyroidien. Ann Endocrinol (Paris) 31:5
43. Renauld A, Andrade LL, Sverdlik RC, Rodriguez RR 1974 Serum insulin response to glucose infusion in hyperthyroid dogs. Horm Metab Res 6:400
44. Okajima F, Ui M 1978 Adrenergic modulation of insulin secretion in uiuo dependent on thyroid states. Am J Physiol 234:E106
45. Renauld A, Sverdlik RC, Garrido D 1980 Blood sugar, serum insulin and serum free fatty acid responses to slow graded glucose in thyroxine-treated dogs. Acta Diabetol Lat 17:189
46. Kuriyama S 1917 The influence of thyroid feeding upon carbohydrate metabolism. Am J Physiol 43:481
47. Dow DS, Allen CE 1961 Steady-state oxidation of glucose in hyperthyroid and hypothyroid rats. Can J Biochem Physiol 39:981
48. Janney NW, Isaacson VI 1918 The blood sugar in thyroid and other endocrine diseases. The significance of hypoglycemia and the delayed blood sugar curve. Arch Intern Med 22:160
49. Scow RO, Cornfield J 1954 Effect of thyroidectomy and food intake on oral and intravenous glucose tolerances in rats. Am J Physiol 179:39
50. Renauld A, Pinto JEB, Sverdlik RC, Foglia VG 1973 Studies on the effect of thyroidectomy on the insulin response to hyperglycaemia in the dog. Acta Physiol Lat Am 23:29
51. Halmi NS, Albert H, Doughman DJ, Granner DK, Spirtos BN 1959 Improved intravenous glucose tolerance in thyroidectomized or hypophysectomized rats treated with triiodothyronine. Endocrinology 64:618
52. Katsilambros N, Ziegler R, Schatz H, Hinz M, Maier V, Pfeiffer EF 1972 Intravenous glucose tolerance and insulin secretion in the rat after thyroidectomy. Horm Metab Res 4:377
53. Renauld A, Sverdlik RC, Andrade LL, Rodriguez RR 1972 Studies on the effect of thyroxine replacement therapy on the increased insulin response to hyperglycemia in the thyroidectomized dog. Horm Metab Res 4:373
54. 4 and propylthiouracil on insulin secretion and glucose uptake in the rat. Endocrinology 94:1502
55. Renauld A, Sverdlik RC, Andrade LL 1974 Effects of hypothyroidism on serum immunoreactive insulin, free fatty acids and blood sugar in the dog as tested for oral glucose tolerance. Horm Metab Res 6:137
56. Levin J 1969 The effects of hormones on the absorptive, metabolic and digestive functions of the small intestine. J Endocrinol 45:315
57. Joseph PK, Subrahmanyam K 1968 Effect of growth hormone, insulin, thyroxine and cortisone on renal gluconeogenesis. Arch Biochim Biophys 127:288
58. Menahan LA, Wieland O 1969 The role of thyroid function in the metabolism of perfused rat liver with particular reference to gluconeogenesis. Eur J Biochem 10:188
59. Hoch FL 1974 Metabolic effects of thyroid hormones. In Greer MA and Solomon DH (eds) Handbook of Physiology, section 7; Endocrinology vol III. Thyroid, American Physiological Society, Washington DC, p 391
60. Althausen FM 1922 Experimental studies in diabetes. Series II. The intestinal pancreatic function in relation to body mass and metabolism. 10. The influence of the thyroid upon diabetes. J Metab Res 1:619
61. Himms-Hagen J 1967 Sympathetic regulation of metabolism. Pharmacol Rev 19:367
62. Ikejiri K, Yamada T, Ogura H 1978 Age-related glucose tolerance in hyperthyroid patients. Diabetes 27:543
63. Hales CN, Hyams DE 1964 Plasma concentrations of glucose, nonesterified fatty acids and insulin during oral glucose tolerance tests in thyrotoxicosis. Lancet 2:69
64. Andreani D, Menzinger G, Fallucca F, Aliberti G, Tamburrano G, Cassano C 1970 Insulin levels in thyrotoxicosis and primary myxoedema: Response to intravenous glucose and glucagon. Diabetologia 6:1
65. Ikeda M 1971 Plasma insulin levels in endocrine diseases II. Plasma insulin levels in the patients with hyperthyroidism. Folia Endocrinol Jap 47:291
66. Cavagnini F, Peracchi M, Raggi U, Bana R, Pontiroli AE, Malinverni A, Pinto M 1974 Impairment of growth hormone and insulin secretion in hyperthyroidism. Eur J Clin Invest 4:71
67. Seino Y, Goto Y, Taminato T, Ikeda M, Imura H 1974 Plasma insulin and glucagon responses to arginine in patients with thyroid dysfunction. J Clin Endocrinol Metab 38:1136
68. Imura H, Seino Y, Ikeda M, Taminato T, Miyamoto Y, Goto Y 1976 Impaired plasma insulin response to arginine in hyperthyroidism. Important role of rise of blood glucose in 2nd phase of insulin release induced by arginine. Diabetes 25:961
69. Zamrazil V, Nedvidkova J, Felt V, Nemec J, Havelka 1976 The influence of thyroid function on the diabetogenic action of triamcinolone in man. Horm Metab Res 8:282
70. Kabadi UM, Eisenstein A 1980 Glucose intolerance in hyperthyroidism: role of glucagon. J Clin Endocrinol Metab 50:392
71. Dieterle P, Bottermann P, Landgraf R, Schwarz K, Scriba PC 1969 Der Kohlenhydratstoffwechsel bei Schilddnisenfunktionsstorungen. Med Klin 64:489
72. Doar JWH, Stamp TCB, Wynn V, Audhya TK 1969 Effects of oral and intravenous glucose loading in thyrotoxicosis. Studies of plasma glucose, free fatty acid, plasma insulin and blood pyruvate levels. Diabetes 18:633
73. Seino Y, Kurahachi H, Goto Y, Taminato T, Ikeda M, Imura H 1975 Comparative insulinogenic effects of glucose, arginine, and glucagon in patients with diabetes mellitus, endocrine disorders and liver disease. Acta Diabetol Lat 12:89
74. Federspil G, Zaccaria M, Casara D, Sicolo N, Scandellari C 1976 Plasma insulin response to glibornuride in thyrotoxicosis. Diabete Metab 2:27
75. Shima K, Sawazaki R, Tanaka R, Morishita S, Tarui S, Nishikawa M 1976 The pancreatic alpha and beta cells responses to 1-arginine and insulin-induced hypoglycaemia in hyperthyroidism. Acta Endocrinol 83:114
76. Andersen oo, Friis T, Rosselin G 1977 Glucose tolerance and insulin secretion in hyperthyroidism. Acta Endocrinol 84:576
77. Wajchenberg BL, Cesar FP, Lerne CE, Didio R, Kieffer J 1978 Plasma insulin disappearance curve after intravenous insulin injection in human hyperthyroidism. Clin Endocrinol 8:233
78. Setoft L, Heding L 1981 Hypersecretion of proinsulin in thyrotoxicosis. Diabetologia 21:103
79. Ohlsen PM, Danowski S, Vidalon C, Ahmad U, Nolan S, Stephan T 1974 Glucose tolerance, insulin, and growth hormone in thyrotoxicosis and myxedema. Endocr Res Commun 1:435
80. Seltzer HS, Allen EW, Herron AL, Brennan MT 1967 Insulin secretion in response to glycemic stimulus: Relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J Clin Invest 46:323
81. Raptis S, Rau RM, Schröder KE, Rothenbuchner G, Pfeiffer EF 1970 Die Dynamik der Insulinsekretion bei der Hypothyreose vor und während der Substitutionstherapie. Klin Wochenschr 48:362
82. Shah JH, Cerchio GM 1973 Hypoinsulinema of hypothyroidism. Arch Intern Med 132:657
83. Andreani D, Fallucca F, Tamburrano G, Iavicoli M, Menzinger G 1974 Insulin, glucagon, and growth hormone in primary adult myxoedemia. Diabetologia 10:7
84. Marecek RL, Feldman JM 1973 Effect of hyperthyroidism on insulin and glucose dynamics in rabbits. Endocrinology 92:1604
85. Lenzen S, Panten U, Hasselblatt A 1975 Thyroxine treatment and insulin secretion in the rat. Diabetologia 11:49
86. Wolf E, Eisenstein AB 1981 Portal vein blood insulin and glucagon are increased in experimental hyperthyroidism. Endocrinology 108:2109
87. Renauld A, Sverdlik RC, Garrido D 1982 Blood sugar serum insulin and serum fatty acid responses to graded glucose pulses in hypothyroid dogs. Acta Diabetol Lat 19:97
88. John T, Morreale de Escobar G, Escobar del Rey F 1970 Differential effects in the rat of thyroidectomy, propylthiouracil and other goitrogens on plasma insulin and thyroid weight. Endocrinology 87:99
89. Wajchenberg BL, Cesar FP, Lerne CE, Souza IT, Pieroni RR, Mattar E 1978 Carbohydrate metabolism in thyrotoxicosis— Studies on insulin secretion before and after remission from hyperthyroid state. Horm Metab Res 10:294
90. Seino Y, Goto Y, Kurahachi H, Sakurai H, Ikeda M, Kadowaki S, Inoue Y, Mori K, Taminato T, Imura H 1977 Alteration of plasma glucagon response to arginine after treatment in patients with diabetes mellitus, Cushing’s syndrome and hypothyroidism. Horm Metab Res 9:28
91. Liljenquist JE, Keller U, Chaisson IL, Cherrington AD 1979 Insulin and glucagon actions and consequences of derangements in secretion. In: De Groot LJ, Cahill GF, Odell WD, Martini L, Potts IT, Nelson DH, Steinberger E, Winegrad AJ (eds). Endocrinology, vol 2. Grune and Stratton, New York, p 981
92. Bailey CJ, Lord IM, Atkins TW 1983 The insulin receptor and diabetes. In: Nattrass M, Santiago I (eds) Recent Advances in Diabetes. Churchill Livingstone, Edinburgh, p 27
93. Malaisse WJ, Malaisse-Lagae F, McCraw EF 1967 Effects of thyroid function upon insulin secretion. Diabetes 16:643
94. Lenzen S, Hasselblatt A 1974 The effect of thyroxine treatment on the dynamics of insulin release from the isolated perfused rat pancreas. Naunyn Schmiedebergs Arch Pharmacol 282:317
95. Lenzen S, Joost HG, Hasselblatt A 1976 Thyroid function and insulin secretion from the perfused pancreas in the rat. Endocrinology 99:125
96. Lenzen S, Joost HG, Hasselblatt A 1976 The inhibition of insulin secretion from the perfused rat pancreas after thyroxine treatment. Diabetologia 12:495
97. Lenzen S 1978 Dose-response studies on the inhibitory effect of thyroid hormones on insulin secretion. Metabolism 27:81
98. Lenzen S, Klöppel G 1978 Insulin secretion and the morphological and metabolic characteristics of pancreatic islets of hyperthyroid obJ ob mice. Endocrinology 103:1546
99. Chilson OP, Sacks J 1959 Effect of hyperthyroidism on distribution of adenosine phosphates and glycogen in liver. Proc Soc Exp Biol Med 101:331
100. Piatnek-Leunissen D, Olson RE 1967 Cardiac failure in the dog as a consequence of exogenous hyperthyroidism. Circ Res 20:242
101. Landau 1911 Die pathologische Histologie der Basedowstruma. Münch med Wochenschr 58:1213
102. Pettavel CA 1914 Weiterer Beitrag zur pathologischen Anatomie des Morbus Basedowii. Mitt Grenzgebiete Med Chir 27:694
103. Holst J 1921 Glycosuria and diabetes in exophthalmic goitre. Acta Med Scand 55:302
104. Kato M 1921 Befunde der endokrinen Organe bei der Basedowschen Krankheit. Verh Jap Ges Pathol 11:48
105. Kraus EJ 1923 Zur Pathologie der basophilen Zellen der Hypophyse. Zugleich ein Beitrag zur Pathologie des Morbus Basedowii and Addisoni. Virchows Arch Pathol Anat 247:421
106. Wegelin G 1926 Schilddrüse. In: Henke F, Lubarsch O (eds) Handbuch der speziellen pathologischen Anatomie, vol. 8, Drüsen mit innerer Sekretion, Springer Verlag, Berlin
107. Schultz A 1921 Über einen Fall von Athyreosis congenita (Myxödem) mit besonderer Berücksichtigung der dabei beobachteten Muskelveränderungen. Virchows Arch Pathol Anat 232:302
108. Bastenie P 1944 Contribution à l’étiologie du myxoedème spontané de l’adulte. Bull Acad R Med (Belg) 9:179
109. Kojima M 1917 Studies on the endocrine glands: Paper I.: The relations between the pancreas and thyroid and parathyroid glands. Q J Exp Physiol 11:255
110. Glaser M 1926 Über die Veränderungen im Pankreas der weißen Maus nach Thyroxininjektionen. W Roux’ Arch Entwicklungsmech 107:98
111. Cameron GR 1929 The influence of thyroid feeding on the islets of Langerhans in the guinea-pig. J Pathol Bacteriol 29:177
112. Watrin J, Florentin P 1929 Action comparée de l’insuline et de la thyroxine sur les glandes endocrines. C R Soc Biol (Paris) 100:111
113. Herring PT 1917 The action of thyroid upon the growth of the body and organs of the white rat. Q J Exp Physiol 11:231
114. Hess WN 192 Islets of Langerhans in the pancreas of white rats. Anat Rec 84:526
115. Kinash B, Haist RE 1955 The influence of the thyroid gland on the islets of Langerhans and the pancreas. Can J Biochem Physiol 33:380
116. Florentin P, Watrin J 1931 Action de la thyroxine sur le pancréas du cobaye. C R Soc Biol (Paris) 107:372
117. Farrant R 1913 Hyperthyroidism: Its experimental production in animals. Br Med J 2:1363
118. Habân G, Angyal F 1938 Das Verhalten der Langerhansschen Inseln in experimentellem Hyperthyreoidismus. Beitr Pathol Anat Allg Pathol 101:602
119. Pirera A 1905 Sui rapporti fra tiroide e pancreas. Intern Sei Med 27:17
120. Houssay BA 1944 Thyroid and metathyroid diabetes. Endocrinology 35:158
121. Kracht J 1962 Das Inselorgan bei Hypothyreose. Frankf Z Pathol 72:24
122. Tatum AL 1913 Morphological studies in experimental cretinism. J Exp Med 1:636
123. Lorand A 1904 Les rapports due pancréas (îlots de Langerhans) avec la thyroide. C R Soc Biol 56:488
124. Falta W 1909 Weitere Mitteilungen über die Wechselwirkung der Drüsen mit innerer Sekretion. Wien Klin Wocnenschr 22:1059
125. Abrams MI, Gilligan DR 1934 Carbohydrate metabolism in human hypothyroidism induced by total ablation of the thyroid gland. II. The blood sugar response to insulin. Am J Med Sei 188:796
126. Papapetrou PD, Koutras DA, Malamos B 1970 Lactate, pyruvate and thyroid function. J Endocrinol 47:519
127. Hübner G, Voss C, Hermann R, Schwandtner V 1974 Zum Verhalten des Lactat:Pyruvat-Quotienten im Blut von Ratten mit experimenteller Hyperthyroxinämie und Hypothyreose. Endokrinologie 63:239
128. Davidson MB 1979 The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 28:688
129. WHO Technical Report Series: WHO expert committee on diabetes mellitus. Second report. Technical Report Series 646. World Health Organisation, Geneva 1980
130. Solomon N, Carpenter CCJ, Bennett IL, Harvey AM 1965 Schmidt’s syndrome (thyroid and adrenal insufficiency) and coexistent diabetes mellitus. Diabetes 14:300
131. Bottazzo GF, Cudworth AG, Moul DJ, Doniach D, Festenstein H 1978 Evidence for a primary autoimmune type of diabetes mellitus. Br Med J 2:1253
132. Smith PH, Porte D 1976 Neuropharmacology of the pancreatic islets. Ann Rev Pharmacol Toxicol 16:269
133. Okajima F, Ui M 1979 Metabolism of glucose in hyperand hypothyroid rats in uiuo. Relation of catecholamine actions to thyroid activity in controlling glucose turnover. Biochem J 182:585
134. Wajchenberg BL, Cesar FP, Lerne CE 1977 Effects of adrenergic stimulating and blocking agents on glucose-induced insulin reponses to human thyrotoxicosis. Metabolism 27:1715
135. Renauld A, Sverdlik RC, Rodríguez RR 1982 Blood concentration of glucose, insulin and free fatty acids in shortly thyroxine-treated dogs: effects of alpha-blockade and isoproterenol. Horm Metab Res 14:101
136. Renauld A, Pinto JEB, Sverdlik RC, Foglia VG 1971 Estudios sobre la velocidad de desaparición de la insulina exógena de la sapgre en el perro. II. Effecto de la tiroxina. Acta Diabetol Lat 8:428
137. Cohen AM 1957 Interrelation of insulin activity and thyroid function. Am J Physiol 188:287
138. 131 degradation. Am J Physiol 180:13
139. Shah JH, Motto GS, Papagiannes E, Williams GA 1975 Insulin metabolism in hypothyroidism. Diabetes 24:922
140. Renauld A, Sverdlik RC, Andrade LL 1974 Effects of hypothyroidism on serum immunoreactive insulin, free fatty acids and blood sugar in the dog as tested for oral glucose tolerance. Horm Metab Res 6:137
141. Meythaler F, Mann H 1937 Über den Einfluß der Schilddrüse auf den Kohlenhydratstoffwechsel. I. Die Wirkungsintensität des Insulins bei Basedow und Myxödem. Klin Wochenschr 16:983
142. Griffiths WJ 1939 Insulin resistance and the diagnosis of thyroid disease. Q J Med 8:23
143. Kellen J 1956 Stoffwechselstörungen im Kohlenhydrathaushalt bei Thyreotoxikose. II. Mitteilung: Zur Frage der Insulinresistenz. Z Inn Med 11:802
144. Zeckwer IT 1933 Some atypical responses of rabbits to insulin. Am J Physiol 106:273
145. de Bodo RC, Altszuler N 1958 Insulin hypersensitivity and physiological insulin antagonists. Physiol Rev 38:389
146. Houssay BA, Busso RR 1924 Sensibilité des animaux éthyroidés vis-a-vis de l’insuline. C R Soc Biol (Paris) 91:1037
147. Lamberg BA 1965 Glucose metabolism in thyroid disease. Acta Med Scand 178:351
148. r(4-methylbenzolsulfonyl)-N.2-butylharnstoff an der Maus. Arzneimittelforsch 8:590
149. Elrick H, Hlad CJ, Arai Y 1961 Influence of thyroid function on carbohydrate metabolism and a new method for assessing response to insulin. J Clin Endocrinol Metab 21:387
150. Okajima F, Ui M 1979 Metabolism of glucose in hyperand hypothyroid rats in vivo. Minor role of endogenous insulin in thyroid-dependent changes in glucose turnover. Biochem J 182:577
151. Heise E, Joost HG, Hasselblatt A 1982 Insulin binding and response to insulin of adipocytes from thyroxine-treated rats. Endocrinology 110:955
152. Müller MJ, Seitz HJ 1980 In vivo turnover in hypoand hyperthyroid starved rat. Pflügers Arch 386:47
153. Vince FP, Boucher BJ, Cohen RD, Godfrey J 1970 The response of plasma sugar, free fatty acids, 11-hydroxycorticosteroids and growth hormone to insulin-induced hypoglycaemia and vasopressin in primary myxoedema. J Endocrinol 48:389
154. Bodansky A 1923 Effect of thyroidectomy upon the reaction of sheep to insulin. Proc Soc Exp Biol Med 21:46
155. Burn JH, Marks HP 1924 On the relation of thyroidectomy to the effect of insulin on the blood sugar of rabbits. J Physiol 59:8
156. Ducheneau L 1924 Action de linsuline sur les lapins éthyroidés. C R Soc Biol (Paris) 90:248
157. Houssay BA, Cisneros A 1925 Sensibilité des chienes éthyroidés a l’égard de l’insuline. C R Soc Biol (Paris) 93:877
158. Aszodi Z, Ernst Z 1927 Die Wirkung der Pankreasextirpation und der darauf folgenden Thyreoektomie auf die Empfindlichkeit von Hunden gegen Insulin. Pflügers Arch 215:431
159. Britton SW, Myers WK 1928 The thyroid gland and the sensitivity of animals to insulin. Am J Physiol 84:132
160. Bose JP 1930 Inter-relationship of some of the important endocrine glands, with special reference to the part they play in influencing the colour and the texture of the skin. Indian J Med Res 18:227
161. Goldblatt MW 1936 Insulin and the thyroidectomized rabbit. J Physiol 86:46
162. Czech MP, Malbon CC, Kerman K 1980 Effect of thyroid status on insulin action in rat adipocytes and skeletal muscle. J Clin Invest 66:574
163. DeRuyter H, Burman KD, Wartowsky L, Taylor SJ 1982 Effects of thyroid hormones on the insulin receptor in rat liver membranes. Endocrinology 110:1922
164. Cech JM, Amatruda JM 1983 The effect of triiodothyronine on insulin binding and action in rat adipocytes. Horm Metab Res 15:530
165. von Noorden C 1917 Die Zuckerkrankheit und ihre Behandlung. August Hirschwald Verlag, Berlin, 7. Aufl., p 304
166. Naunyn B 1900 Der Diabetes Melitus. In: Nothnagel H (ed) Specielle Pathologie und Therapie, vol 7.1, Der Diabetes Melitus, Alfred Holder K.u.K. Hofund Universitäts-Buchhändler, Wien, p 415
167. Falta W 1909 Über die Korrelationen der Drüsen mit innerer Sekretion. Ergeh Wiss Med 1:108
168. West KM 1978 Epidemiology of diabetes and its vascular lesions. Elsevier, New York
169. Oakley WG, Pyke DA, Taylor KW 1978 Diabetes and its management. 3rd edition. Blackwell Scientific, Oxford
170. Kalkhoff RK 1972 Effects of oral contraceptive agents and sex steroids on carbohydrate metabolism. Ann Rev Med 23:429
171. Kalkhoff RK 1975 Effects of oral contraceptive agents on carbohydrate metabolism. J Steroid Biochem 6:949
172. Schreibeman PH 1968 Alterations in carbohydrate and lipid metabolism by a progestin. Diabetes 17:341
173. Thaddea S, Hampe H 1940 Über den Einfluß der Keimdrüsenhormone auf die Stoffwechsellage des Altersdiabetes. Z Klin Med 137:760
174. Foglia VG, Schuster N, Rodriguez RR 1947 Sex and diabetes. Endocrinology 41:428
175. Houssay BA 1951 Action of sex hormones on experimental diabetes. Br Med J 2:505
176. Houssay BA, Foglia VG, Rodriguez RR 1954 Production or prevention of some types of experimental diabetes by oestrogens or corticosteroids. Acta Endocrinol 17:146
177. Rossini AA, Williams RM, Appel MC, Like AA 1978 Sex differences in the multiple dose streptozotocin model of diabetes. Endocrinology 103:1518
178. Maclaren NK, Neufeld M, Mclaughlin JV, Taylor G 1980 Androgen sensitisation of streptozotocin induced diabetes in mice. Diabetes 29:710
179. Barnes BO, Regan JF, Nelson WO 1933 Improvement of experimental diabetes following the administration of amniotin. J Am Med Assoc 101:926
180. Nelson WO, Overholser MD 1936 The effect of oestrogenic hormone on experimental pancreatic diabetes in the monkey. Endocrinology 20:473
181. Ingle DJ 1941 Diabetogenic effect of stilbestrol in force fed normal and partially depancreatized rats. Endocrinology 29:838
182. Janes RG, Dawson H 1946 The influence of diethylstilbestrol on alloxan diabetes. Paired feeding experiments. Endocrinology 38:10
183. Rodriguez RR 1954 Alloxan diabetes in the rat: recovery following estrogen treatment. Endocrinology 55:1
184. Goodman MN, Hazelwood RL 1974 Short-term effects of oestradiol benzoate in normal, hypophysectomized and alloxan-diabetic male rats. J Endocrinol 62:439
185. Lewis JT, Foglia VG, Rodriguez RR 1950 The effects of steroids on the incidence of diabetes in rats after subtotal pancreatectomy. Endocrinology 46:111
186. Ingle DJ, Nezamis JE, Prestrud MC 1947 The effect of diethylstilbestrol upon alloxan diabetes in the male rat. Endocrinology 41:207
187. Kalkhoff RK, Jacobson M, Lemper D 1970 Progesterone, pregnancy and the augmented plasma insulin response. J Clin Endocrinol Metab 31:24
188. Talaat M, Habib YA, Habib M 1957 The effect of testosterone on the carbohydrate metabolism in normal subjects. Arch Int Pharmacodyn Ther 111:215
189. Talaat M, Habib YA, Higazy AM, Abdel Naby S, Malek AY, Ibrahim ZA 1965 Effect of sex hormones on the carbohdyrate metabolism in normal and diabetic women. Arch Int Pharmacodyn Ther 154:402
190. Buchler D, Warren JC 1966 Effects of estrogen on glucose tolerance. Am J Obstet Gynecol 95:479
191. Benjamin F, Casper DJ 1966 Alterations in carbohydrate metabolism induced by progesterone in cases of endometrial carcinoma and hyperplasia. Am J Obstet Gynecol 94:991
192. Goldman JA, Ovadia JL, Eckerling B 1968 Effect of progesterone on glucose tolerance in women. Isr J Med Sei 4:878
193. Goldman JA, Ovadia JL 1969 The effect of estrogen on intravenous glucose tolerance in women. Am J Obstet Gynecol 103:172
194. Agabor LN, Tsai CC, Vela P, Yen SSC 1972 Effect of exogenous estrogen on carbohydrate metabolism in post-menopausal women. Am J Obstet Gynecol 113:383
195. Notelovitz M 1974 Metabolic effects of conjugated estrogen (USP) on glucose tolerance. South Afr Med J 48:2599
196. Spellacy WN, Buhi WC, Birk SA 1978 Studies of carbohydrate and lipid metabolism in women using the progesterone-T intrauterine device for six months. Blood glucose, cholesterol and triglyceride levels. Fertil Steril 29:505
197. Novak R, Wilimas J, Johnson W 1979 Hypertrophy and hyperplasia of islets of Langerhans associated with androgen therapy. Arch Pathol 103:483
198. Bailey CJ, Ahmed-Sorour H 1980 Role of ovarian hormones in the long-term control of glucose homeostasis. Effects on insulin secretion. Diabetologia 19:475
199. ElSeifi S, Green IC, Perrin D 1981 Insulin release and Steroidhormone binding in isolated islets of Langerhans in the rat: effects of ovariectomy. J Endocrinol 90:59
200. Faure A, Sutter-Dub MT, Sutter BCJ, Assan R 1983 Ovarianadrenal interactions in regulation of endocrine pancreatic function in the rat. Diabetologia 24:122
201. Howell SL, Tyhurst M, Green IC 1977 Direct effects of progesterone on rat islets of Langerhans in vivo and in tissue culture. Diabetologia 13:579
202. Bailey CJ, Matty AJ 1972 Glucose tolerance and plasma insulin of the rat in relation to the oestrous cycle and sex hormones. Horm Metab Res 4:266
203. Talaat M, Habit YA, Malek A 1959 Effect of oestradiol dipropionate on the carbohdyrate metabolism in the liver and muscle of adult female rabbits. Arch Int Pharmacodyn Ther 123:490
204. Thomas JA 1963 Modification of glucagon-induced hyperglycemia by various steroidal agents. Metabolism 12:207
205. Basabe JC, Chieri RA, Foglia VG 1969 Action of sex hormones on the insulinemia of castrated female rats. Proc Soc Exp Biol Med 130:1159
206. Costrini NV, Kalkhoff RK 1971 Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion. J Clin Invest 50:992
207. Matute ML, Kalkhoff RK 1973 Sex steroid influence on hepatic gluconeogenesis and glycogen formation. Endocrinology 92:762
208. Shamoon H, Felig P 1974 Effects of estrogen on glucose uptake by rat muscle. Yale J Biol Med 47:227
209. Mandour T, Kissebah AH, Wynn V 1977 Mechanism of oestrogen and progesterone effects on lipid and carbohydrate metabolism: alteration in the insulin:glucagon molar ratio and hepatic enzyme activity. Eur J Clin Invest 7:181
210. Sutter-Dub MT, Faure A, Aerts L, van Assche FA 1978 Effects of progesterone and 17-J S-oestradiol treatments on the pancreatic B cell in castrated female rats. Biochemical variations. J Physiol (Paris) 74:725
211. Renauld A, von Lawzewitsch I, Pérez RL, Sverdlik R, Agüero A, Foglia VG, Rodriguez RR 1983 Effect of estrogens on blood sugar, serum insulin and serum free fatty acids, and pancreas cytology in female dogs. Acta Diabetol Lat 20:47
212. Ashby JP, Shirling D, Baird JD 1978 Effect of progesterone on insulin secretion in the rat. J Endocrinol 76:479
213. Beck P 1969 Progestin enhancement of the plasma insulin response to glucose in rhesus monkeys. Diabetes 18:146
214. Talaat M, Habib YA, Hanna T 1958 Effect of testosterone propionate on the the carbohydrate metabolism in the liver and muscle of male rabbits. Arch Int Pharmacodyn Ther 116:410
215. Renauld A, Sverdlik RC 1975 Influence of testosterone on blood sugar, serum insulin and free fatty acid responses to glucose in normal male dog. Acta Physiol Lat Am 25:59
216. Renauld A, Sverdlik RC, Fels RC, von Lawzewitsch I, Perez RL, Foglia VG, Rodriguez RR 1980 Metabolic and histological pancreatic changes induced by orchidectomy in dogs. Horm Metab Res 12:370
217. Lewis LA, McCullagh EP 1942 Carbohydrate metabolism of animals treated with methyl testosterone and testosterone propionate. J Clin Endocrinol 2:502
218. Wade GN 1975 Some effects of ovarian hormones on food intake and body weight in female rats. J Comp Physiol Psychol 88:183
219. Gentry RT, Wade GN 1976 Androgenic control of food intake and body weight in male rats. J Comp Physiol Psychol 90:18
220. Song CS, Kappas A 1968 The influence of estrogens, progestins, and pregnancy on the liver. Vitam Horm 26:147
221. Ashby JP, Shirling D, Baird JD 1981 Effect of progesterone on the secretion and peripheral action of insulin and glucagon in the intact rat. J Endocrinol 88:49
222. Hamburger AD, Kuipers ACJ, van der Vies J 1975 The effect of progesterone on plasma insulin in the rabbit. Experientia 31:602
223. Ahmed-Sorour H, Bailey CJ 1980 Role of ovarian hormones in the long-term control of glucose homeostasis. Interaction with insulin, glucagon and epinephrine. Horm Res 13:396
224. Faure A, Sutter-Dub MT 1979 Insulin secretion from isolated pancreatic islets in the female rat. Short and long term oestradiol influence. J Physiol (Paris) 75: 289
225. Hager D, Georg RH, Leitner JW, Beck P 1972 Insulin secretion and content in isolated rat pancreatic islets following treatment with gestational hormones. Endocrinology 91:977
226. Haist RE 1965 Effects of steroids on the pancreas. Methods Horm Res 4:193
227. Lenzen S 1978 Effects of ovariectomy and treatment with progesterone or oestradiol-17J 3 on the secretion of insulin by the perfused rat pancreas. J Endocrinol 78:153
228. 3H-progesterone by isolated rat islets of Langerhans. Diabetologia 15:349
229. Winborn WB, Sheridan PJ, McGill HC 1983 Estrogen receptors in the islets of Langerhans of baboons. Cell Tissue Res 230:219
230. Tesone M, Chazenbalk GC, Ballejos G, Charreau EH 1979 Estrogen receptor in rat pancreatic islets. J Steroid Biochem 11:1309
231. Chan L, O’Malley BW 1978 Steroid hormone action: recent advances. Ann Intern Med 89:674
232. Aerts L, van Assche FA, Faure A, Sutter-Dub MT 1980 Effects of treatment with progesterone and oestradiol-17J 3 on the endocrine pancreas in ovariectomized rats: ultrastructural variations in the B cells. J Endocrinol 84:317
233. Talaat M, Habib YA, Abd El Naby S, Hamdi H, Malek AY, Ibrahim ZA, Saad AF 1965 Effect of oestradiol dipropionate on the glucose tolerance and insulin sensitivity curves in normal and ovarectomized female rabbits. Arch Int Pharmacodyn Ther 153:290
234. McKerns KW, Coulomb B, Kaleita E, De Renzo EC 1958 Some effects of in vivo administered estrogens on glucose metabolism and adrenal cortical secretion in vitro. Endocrinology 63:709
235. Gilmour KE, McKerns KW 1966 Insulin and estrogen regulation of lipid synthesis in adipose tissue. Biochim Biophys Acta 116:220
236. Sutter-Dub MT, Dazey B, Vergnaud MT, Madac AM 1981 Progesterone and insulin resistance in the pregnant rat. I. In vivo and in vitro studies. Diabete Metab 7:97
237. Ciccoli L, Berganini E 1974 Interactions between testosterone and insulin in the regulation of glycogen metabolism in the rat perineal muscles. Steroids Lipids Res 5:321
238. Adams PW, Oakley NW 1972 Oral contraceptives and carbohydrate metabolism. Clin Endocrinol Metabol 1:697
239. Beck P 1973 Contraceptive steroids: Modifications of carbohydrate and lipid metabolism. Metabolism 22:841
240. Hausmann L, Kaffarnik H 1975 Einfluß von Ovulationshemmern auf den Glucosestoffwechsel. Dtsch Med Wochenschr 100:1703
241. Spellacy WN 1969 A review of carbohydrate metabolism and the oral contraceptives. Am J Obstet Gynecol 104:448
242. Danowski TS, Sabeh G, Alley RA, Robbins TJ, Tsai CT, Sekaran K 1968 Glucose tolerance prior to and during therapy with contraceptive steroids. Clin Pharmacol Ther 9:223
243. Posner NA, Silverstone FA, Tobin EH, Breuer J 1975 Changes in carbohydrate tolerance during long-term oral contraception. Am J Obstet Gynecol 123:119
244. Muck BR 1976 Effect of long term use of oral contraceptives on glucose tolerance. Arch Gynaekol 220:185
245. Wingrave SJ, Kay CR, Vessey MP 1979 Oral contraceptives and diabetes mellitus. Br Med J 1:23
246. de Pirro R, Forte F, Bertoli A, Greco AV, Lauro R 1981 Changes in insulin receptors during oral contraception. J Clin Endocrinol Metab 52:29
247. Krauth MC, Schillinger E 1977 Changes in the insulin receptor concentration in rat fat cells following treatment with the gestagens clomegestone acetate and cyproterone acetate. Acta Endocrinol 86:667
248. Kühl C 1977 Serum insulin and plasma glucagon in human pregnancy. On the pathogenesis of gestational diabetes. Acta Diabetol Lat 14:1
249. Rosenloecher K 1932 Die Veränderungen des Pankreas in der Schwangerschaft bei Mensch und Tier. Arch Gynaekol 151:567
250. Green IC, Taylor KW 1972 Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans. J Endocrinol 54:317
251. Aerts L, van Asche FA 1975 Ultrastructural changes of the endocrine pancreas in pregnant rats. Diabetologia 11:285
252. Bone AJ, Howell SL 1977.Alterations in regulation of insulin biosynthesis in pregnancy and starvation studied in isolated rat islets of Langerhans. Biochem J 166:501
253. Kalkhoff RK, Kim HJ 1978 Effects of pregnancy on insulin and glucagon secretion by perifused rat pancreatic islets. Endocrinology 102:623
254. Freinkel N 1980 Of pregnancy and progeny. Diabetes 29:1023
255. Kalkhoff R, Schalch DS, Walker JL, Beck P, Kipnis DM, Daugh-aday WH 1964 Diabetogenic factors associated with pregnancy. Trans Assoc Am Physicians 77:270
256. Russi S, Blumenthal HT, Gray SH 1945 Small adenomas of the adrenal cortex in hypertension and diabetes. Arch Intern Med 76:284
257. Conn JW, Fajans SS 1956 Influence of adrenal cortical steroids on carbohydrate metabolism in man. Metabolism 5:114
258. Tzagournis M, Hamwi GJ 1967 The prevalence of diabetes mellitus in patients with Addison’s disease: Measurements of serum insulin levels. Metabolism 16:213
259. Beaven DW, Nelson HD, Renold AE, Thorn GW 1959 Diabetes mellitus and Addison’s disease. A report on eight patients and a review of 55 cases in the literature. New Engl J Med 261:443
260. Wehrmacher WH 1961 Addison’s disease with diabetes mellitus. Arch Intern Med 108:114
261. Long CNH, Katzin B, Fry EG 1940 The adrenal cortex and carbohydrate metabolism. Endocrinology 26:309
262. Franckson JRM, Gepts W, Bastenie PA, Conard V, Cordier N, Kovacs L 1953 Observations sur le diabete steroide experimental du rat. Acta Endocrinol 14:153
263. Hausberger FX, Ramsay AJ 1955 Steroid diabetes in guinea pigs: Effects of hydrocortisone administration on blood and urinary glucose, nitrogen excretion, fat deposition, and the islets of Langerhans. Endocrinology 56:533
264. Bates RW, Garrison MM 1973 Synergism among growth hormone, ACTH, cortisol and dexamethasone in the hormonal induction of diabetes in rats and diabetogenic effect of tolbutamide. Endocrinology 93:1109
265. Campbell J, Rastogi KS, Hausier HR 1966 Hyperinsulinemia with diabetes induced by cortisone, and the influence of growth hormone in the Chinese hamster. Endocrinology 79:749
266. Hausberger FX, Ramsay AJ 1953 Steroid diabetes in guinea pigs. Effects of cortisone administration on bloodand urinary glucose, nitrogen excretion, fat deposition, and the islets of Langerhans. Endocrinology 53:423
267. Abelove WA, Paschkis KE 1954 Comparison of the diabetogenic action of cortisone and growth hormone in different species. Endocrinology 55:637
268. Vranic M 1965 Effects of cortisol in guinea pigs with normal and atrophic exocrine pancreas. Diabetes 14:194
269. Kern H, Logothetopoulos J 1970 Steroid diabetes in the guinea pig. Studies on islet-cell ultrastructure and regeneration. Diabetes 19:145
270. Murakami M, Tonutti E 1972 Zur Ultrastruktur des Inselapparates beim Steroiddiabetes des Meerschweinchens. Endokrinologie 59:127
271. Lazarus SS, Bencosme SA 1955 Alterations of pancreas during cortisone diabetes in rabbits. Proc Soc Exp Biol Med 89:114
272. Lazarus SS, Bencosme SA 1956 Development and regression of cortisone-induced lesions in rabbit pancreas. Am J Clin Pathol 26:1146
273. Ingle DJ, Sheppard R, Evans JS, Kuizenga MH 1945 A comparison of adrenal steroid diabetes and pancreatic diabetes in the rat. Endocrinology 37:341
274. Ingle DJ 1956 Experimental steroid diabetes. Diabetes 5:187
275. Houssay BA, Rodriguez RR, Cardeza AF 1954 Prevention of experimental diabetes with adrenal steroids. Endocrinology 54:550
276. Bates RW, Garrison MM 1971 Studies in 80% pancreatectomized rats of the synergistic interaction of growth hormone, ACTH and the glucocorticoids (corticosterone, cortisol, prednisone and dexamethasone) as diabetogenic agents. Endocrinology 88:1429
277. Frouin A 1908 Ablation des capsules surrénales et diabète pancréatique. C R Soc Biol (Paris) 64:216
278. Long CNH, Lukens FDW 1936 The effects of adrenalectomy and hypophysectomy upon experimental diabetes in the cat. J Exp Med 63:465
279. Long CNH, Lukens FDW, Dohan FC 1937 Adrenalectomizeddepancreatized dogs. Proc Soc Exp Biol Med 36:553
280. Perley M, Kipnis DM 1966 Effect of glucocorticoids on plasma insulin. New Engl J Med 274:1237
281. Kitabchi AE, Jones GM, Duckworth WC 1973 Effect of hydro cortisone and corticotropin on glucose-induced insulin and proinsulin secretion in man. J Clin Endocrinol Metab 37:79
282. Marco J, Calle C, Román D, Diaz-Fierros M, Villanueva ML, Valverde I 1973 Hyperglucagonism induced by glucocorticoid treatment in man. New Engl J Med 288:128
283. Wise JK, Hendler R, Felig P 1973 Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. J Clin Invest 52:2774
284. Kalhan SC, Adam PAJ 1975 Inhibitory effect of prednisone on insulin secretion in man: Model for duplication of blood glucose concentration. J Clin Endocrinol Metab 41:600
285. Fantus IG, Ryan J, Hizuka N, Gorden P 1981 The effect of glucocorticoids on the insulin receptor: an in vivo and in vitro study. J Clin Endocrinol Metab 52:953
286. Serrano-Rios M, Hawkins FG, Escobar F, Mato JM, Larrodera L, de Oya M, Rodriguez-Minon JL 1974 Insulin secretion in Addison’s disease: Effect of hydrocortisone treatment. Horm Metab Res 6:17
287. Bastenie PA, Conard V, Franckson JRM 1954 Effect of cortisone on carbohydrate metabolism measured by the “glucose assimilation coefficient”. Diabetes 3:205
288. Gács G, Berend K 1974 Plasma glucose, insulin and free fatty acids during long-term corticosteroid treatment in children. Acta Endocrinol 77:699
289. Porges O 1910 Über Hypoglykämie bei Morbus Addison sowie bei nebennierenlosen Hunden. Z Klin Med 69:341
290. Kitabchi AE, Buchanan KD, Vanee JE, Williams RH 1968 Effect of adrenocorticotropin and glucocorticoids on insulin secretion. J Clin Endocrinol Metab 28:1479
291. Britton SW, Silvette H 1931 Some effects of cortico-adrenal extract and other substances on adrenalectomized animals. Am J Physiol 99:15
292. Creutzfeldt W, Detering L, Weite O 1957 Das B-Zellensystem von normalen und hypophysektomierten Ratten sowie von Kaninchen unter D 860 und diabetogenen Hormonen. Dtsch Med Wochenschr 82:1564
293. Weinges K, Maske H 1957 Pankreatektomie und Cortisonwirkung bei Meerschweinchen. Arch Exp Pathol Phamakol 231:440
294. Volk BW, Lazarus SS 1958 The effect of various diabetogenic hormones on the structure of the rabbit pancreas. Am J Pathol 34:121
295. Volk BW, Lazarus SS 1959 Morphologic reflection of increasing insulinogenesis during chronic hyperglycemia in the rabbit. Ann NY Acad Sei 82:319
296. Bassett JM, Wallace ALC 1967 Influence of cortisol on plasma insulin in the sheep. Diabetes 16:566
297. Cudworth AG, Barber HE 1975 The effect of hydrocortisone phosphate, methylprednisolone and phenytoin on pancreatic insulin release and hepatic glutathione-insulin transhydrogenase activity in the rat. Eur J Pharmacol 31:23
298. Malaisse WJ, Malaisse-Lagae F, McCraw EF, Wright PH 1967 Insulin secretion in vitro by pancreatic tissue from normal adrenalectomized, and cortisol-treated rats. Proc Soc Exp Biol Med 124:924
299. Campbell J, Rastogi KS 1968 Elevation in serum insulin, albumin, and FFA, with gains in liver lipid and protein, induced by glucocorticoid treatment in dogs. Can J Physiol Pharmacol 46:421
300. Marco J, Melani F, Goberna R, Rott WH, Pfeiffer EF 1968 Einfluß der Prednisolonbehandlung auf die Insulinsekretion der Ratte. Diabetologia 4:365
301. Ákerblom HK, Martin JM, Gary GL 1973 Relative role of cortisone and growth hormone on glucose intolerance and insulin secretion in rat. Horm Metab Res 5:34
302. Schmidt-Wiederkehr P 1973 Zur Morphologie und Histochemie des Inselapparates beim experimentellen Steroiddiabetes des Meerschweinchens, insbesondere unter dem Einfluß von Actinomycin D. Endokrinologie 61:237
303. Like AA, Chick WL 1974 Pancreatic beta cell replication induced by glucocorticoids in subhuman primates. Am J Pathol 75:329
304. Van Lan V, Yamaguchi N, Garcia MJ, Ramey ER, Penhos JC 1974 Effect of hypophysectomy and adrenalectomy on glucagon and insulin concentration. Endocrinology 94:671
305. Lenzen S 1976 The effect of hydrocortisone treatment and adrenalectomy on insulin and glucagon secretion from the perfused rat pancreas. Endokrinologie 68:189
306. Kawai A, Kuzuya N 1977 On the role of glucocorticoid in glucoseinduced insulin secretion. Horm Metab Res 9:361
307. Graf R, Klessen C 1981 Glycogen in pancreatic islets of steroid diabetic rats. Carbohydrate histochemical detection and localization using an immunocytochemical technique. Histochemistry 73:225
308. Borelli MI, Garcia ME, Dumm CLG, Gagliardino JJ 1982 Glucocorticoid-induced changes in insulin secretion related to the metabolism and ultrastructure of pancreatic islets. Horm Metab Res 14:287
309. Baxter JD 1976 Glucocorticoid hormone action. Pharmacol Ther 2:605
310. Felig P, Sherwin RS, Soman V, Wahren I, Hendler R, Sacca L, Eigler N, Goldberg D, Walesky M 1979 Hormonal alterations in the regulation of blood glucose. Rec Prog Horm Res 35:501
311. Modigliani E, Strauch G, Luton JP, Bricaire H 1970 Effects du glucose et de l’arginine sur la sécrétion d’insuline au cours des syndromes de Cushing. Diabetologia 6:8
312. Billaudel B, Sutter BCJ 1979 Direct effect of corticosterone upon insulin secretion studied by three different techniques. Horm Metab Res 11:555
313. Barseghian G, Levine R 1980 Effect of corticosterone on insulin and glucagon secretion by the isolated perfused rat pancreas. Endocrinology 106:547
314. Billaudel B, Sutter BCJ 1981 Effect of corticosterone upon response to L(—)leucine of isolated rats Langerhans islets. Horm Metab Res 13:530
315. Barseghian G, Levine R, Epps P 1982 Direct effect of cortisol and cortisone on insulin and glucagon secretion. Endocrinology 111:1648
316. Coore HG, Randle PJ 1964 Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro. Biochem J 93:66
317. Brunstedt J, Nielsen JH 1981 Direct long-term effect of hydrocortisone on insulin and glucagon release from mouse pancreatic islets in tissue culture. Acta Endocrinol 96:498
318. Haist RE, Bell HJ 1944 Adrenalectomy, gonadectomy and the insulin content of the pancreas. Am J Physiol 141:606
319. Kinash B, Haist RE 1954 Effect of ACTH and of cortisone on the islets of Langerhans and the pancreas in intact and hypophysectomized rats. Am J Physiol 178:441
320. Sloper JC 1954 Small pancreatic islet adenomata in Addison’s disease. Report of two cases with an analysis of islet size in these and fourteen other cases. Arch Pathol 58:294
321. 131 degradation. Am J Physiol 180:9
322. 131 in normal and cortisone-treated rabbits. J Lab Clin Med 49:331
323. Kahn CR, Goldfine ID, Neville DM, de Meyts P 1978 Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. Endocrinology 103:1054
324. Beck-Nielsen H, De Pirro R, Pedersen O 1980 Prednisone increases the number of insulin receptors on monocytes from normal subjects. J Clin Endocrinol Metab 50:1
325. De Pirro R, Bertoli A, Fusco A, Testa I, Greco AV, Lauro R 1980 Effect of dexamethasone and cortisone on insulin receptors in. normal human male. J Clin Endocrinol Metab 51:503
326. Häring H, Calle C, Bug A, Renner R, Hepp KD, Kemmler W 1980 Insulin binding and insulin action in rat fat cells after adrenalectomy. Diabetologia 19:379
327. Yasuda K, Kitabchi AE 1980 Decreased insulin binding of human erythrocytes after dexamethasone or prednisone ingestion. Diabetes 29:811
328. De Pirro R, Bertoli A, Greco AV, Lauro R 1981 Transient effect of glucocorticoids on red blood cell insulin receptors. Horm Metab Res 13:483
329. De Pirro R, Green A, Kao MYC, Olefsky JM 1981 Effects of prednisolone and dexamethasone in vivo and in vitro—studies on insulin binding, deoxyglucose uptake and glucose oxidation in rat adipocytes. Diabetologia 21:149
330. Caro JF, Amatruda JM 1982 Glucocorticoid-induced insulin resistance. The importance of postbinding events in the regulation of insulin binding, action, and degradation in freshly isolated and primary cultures of rat hepatocytes. J Clin Invest 69:866
331. Rizza RA, Mandarino LJ, Gerich JE 1982 Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. J Clin Endocrinol Metab 54:131
332. Canivet B, Poustis-Delpont C, Mariani R, Freychet P 1983 Prednisone increases the number of insulin receptors in erythrocytes from children. Pediatr Res 17:672
333. Pagano G, Cavallo-Perin P, Cassader M, Bruno A, Ozzello A, Masciola P, Dall’omo AM, Imbimbo B 1983 An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. J Clin Invest 72:1814
334. Cahill GF 1971 Action of adrenal cortical steroids on carbohydrate metabolism. In: Christy N (ed) The human adrenal cortex. Academic Press, New York, p 205
335. Munck A 1971 Glucocorticoid inhibition of glucose uptake by peripheral tissues: old and new evidence, molecular mechanisms, and physiological significance. Perspect Biol Med 14:265
336. Olefsky JM, Kimmerling G 1976 Effects of glucocorticoids on carbohydrate metabolism. Am J Med Sei 271:202
337. Shamoon H, Soman V, Sherwin RS 1980 The influence of acute physiological increments of cortisol on fuel metabolism and in sulin binding to monocytes in normal humans. J Clin Endocrinol Metab 50:495
338. Olefsky JM, Johnson J, Liu F, Jen P, Reaven GM 1975 The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes. Metabolism 24:517
339. Bennett GV, Cuatrecasas P 1972 Insulin receptor of fat cells in insulin-resistant metabolic states. Science 176:805
340. Olefsky JM 1975 Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J Clin Invest 56:1499
341. Fantus IG, Saviolakis GA, Hedo JA, Gorden P 1982 Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes. J Biol Chem 257:8277
342. Salhanick AI, Krupp MN, Amatruda JM 1983 Dexamethasone stimulates insulin receptor synthesis in cultured rat hepatocytes. J Biol Chem 258:14130
343. Knutson VP, Ronnett GV, Lane MD 1982 Control of insulin receptor level in 3T3 cells: Effect of insulin-induced down-regulation and dexamethasone-induced up-regulation on rate of receptor inactivation. Proc Natl Acad Sci (USA) 79:2822
344. Grunfeld G, Baird K, van Obberghen E, Kahn CR 1981 Glucocorticoid-induced insulin resistance in vitro: Evidence for both receptor and postreceptor defects. Endocrinology 109:1723
345. Cigolini M, Smith U 1979 Human adipose tissue in culture. VIII. Studies on the insulin-antagonistic effect of glucocorticoids. Metabolism 28:502