Conformational energy studies and in Vitro and in Vivo activity data on growth hormone-releasing peptides

Endocrinology

Volumn 114, Issue 5, 1984, Pages 1531-1536

  Momany, F A ^a   Bowers, C Y ^b   Reynolds, G A ^b   Hong, A ^a,b,c   Newlander, K ^a,b,c  

^a UNIVERSITY OF MEMPHIS   (United States)

^b TULANE UNIVERSITY MEDICAL CENTER   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR FRAGMENT; HEXAPEPTIDE; PENTAPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG COMPARISON; DRUG SCREENING; DRUG STRUCTURE; ENDOCRINE SYSTEM; HYPOPHYSIS; IN VITRO STUDY; NONHUMAN; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; FEMALE; GROWTH HORMONE-RELEASING HORMONE; MICE; OLIGOPEPTIDES; PITUITARY GLAND; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0021368643     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo-114-5-1531     Document Type: Article

References (14)

1. Momany FA, Bowers CY, Reynolds GA, Chang D, Hong A, Newlander K 1981 Design, synthesis, and biological activity of peptides which release growth hormone in vitro. Endocrinology 108: 31
2. Bowers CY, Chang J, Momany FA, Folkers K 1977 Effect of the enkephalins and enkephalin analogs on release of pituitary hormones in vitro. In: Maclntyre I (ed) Molecular Endocrinology. Elsevier/North Holland, Amsterdam, p 287
3. Bowers CY, Momany FA, Reynolds GA, Chang D, Hong A, Chang K 1981 Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro. Endocrinology 106: 663
4. Bowers CY, Reynolds GA, Chang D, Hong A, Chang K, Momany FA 1981 A study of the regulation of growth hormone release from the pituitaries of rats in vitro. Endocrinology 108: 1071
5. Bowers CY, Momany FA, Reynolds GA, Hong A 1984 On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114: 1537
6. IUPAC-IUB 1970 Commission on biochemical nomenclature. J Mol Biol 52: 1
7. FORTRAN computer program ECEPP 1975 Quantum Chemistry Program Exchange. Indiana University, Bloomington, IN order no. QCPE 286
8. Momany FA, McGuire RF, Burgess AW, Scheraga HA 1975 Energy parameters in polypeptides. VII. Geometric parameters, partial atomic charges, nonbonded interactions, hydrogen bond interactions, and intrinsic torsional potentials for the naturally occurring amino acids. J Phys Chem 79: 2361
9. Powell MJD 1964 An efficient method for finding the minimum of a function of several variables without calculating derivatives. Comput J 7: 155
10. Momany FA 1976 Conformational energy analysis of the molecule luteinizing hormone-releasing hormone. I. Native decapeptide. J Am Chem Soc 98: 2990
11. Manavalan P, Momany FA 1980 Conformational energy studies on N-methylated analogs of Thyrotropin Releasing Hormone, Enkephalin, and Luteinizing Hormone-Releasing Hormone. Biopolymers 19: 1943
12. Stewart JM, Young SD 1968 Solid phase peptide synthesis. Freeman, San Francisco
13. Bodansky M, Klausen YS, Anditti MA 1976 Peptide synthesis. John Wiley and Sons, New York
14. Fujino M, Kobaysahi S, Obayashi M, Fukuda T, Shinagawa S, Yamazaki I, Nakayama R, White WF, Rippel RH 1972 Synthesis and biological activities of luteinizing hormone releasing hormone (LH-RH). Biochem Biophys Res Commun 49: 698