Synaptic density and axonal sprouting in rat hippocampus: stability in adulthood and decline in late adulthood

Brain Research

Volumn 294, Issue 1, 1984, Pages 152-156

  McWilliams, J R ^a   Lynch, G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

aging; axonal degeneration; axonal sprouting; hippocampus

Indexed keywords

AGE; AGING; ANIMAL CELL; CENTRAL NERVOUS SYSTEM; DENTATE GYRUS; HIPPOCAMPUS; HISTOLOGY; NERVE SPROUTING; NERVOUS SYSTEM; NONHUMAN; RAT; SYNAPSE;

AGING; ANIMAL; AXONS; HIPPOCAMPUS; NERVE DEGENERATION; RATS; RATS, INBRED STRAINS; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPSES;

EID: 0021367092     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(84)91321-0     Document Type: Article

References (28)

1. Loss of synapses in the dentate gyrus of the senescent rat
2. Synaptic growth in aged animals
3. The effect of collateral sprouting on the density of innervation of normal target sites: implications for the theories on the regulation of the size of developing synaptic domains
4. Accelerated rates of synaptogenesis by ‘sprouting’ afferents in the immature hippocampal formation
5. Decrease in the number of synapses in the senescent brain: a quantitative electron microscopic analysis of the dentate gyrus molecular layer in the rat
6. Partial deafferentation of neurons in the dentate gyrus of the senescent rat
7. Neuronal plasticity in primate telencephalon: anomalous projections induced by prenatal removal of frontal cortex
8. Motor-sensory and visual behavior after hemispherectomy in newborn and mature rats
9. Aging in the rat olfactory bulb: quantitative changes in mitral cell organelles and somato-dendritic synapses
10. Lesion-induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and reacquisition of normal synaptic density
11. Lesion-induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response
12. Lesion-induced rerouting of hippocampal mossy fibers in developing but not in adult rats
13. Ultrastructural evidence for bouton sprouting in the adult mammalian brain
14. The effects of successive lesions on the time course of the sprouting response in the hippocampus of the rat
15. The response of the dentate gyrus to partial deafferentation
16. Mortality and growth characteristics of rat strains commonly used in aging research
17. A quantitative ultrastructural analysis of synaptic changes in the rat dentate gyrus following entorhinal lesions. I. Magnitude and time course of degeneration
18. Terminal proliferation and synaptogenesis following partial deafferentation: the reinnervation of the inner molecular layer of the dentate gyrus following removal of its commissural afferents
19. Terminal proliferation in the partially deafferented dentate gyrus: time courses for the appearance and removal of degeneration and the replacement of lost terminals
20. Sprouting in the hippocampus is accompanied by an increase in coated vesicles
21. Rate of synaptic replacement in denervated rat hippocampus declines precipitously from the juvenile period to adulthood
22. Neuronal plasticity in the septal nuclei of the adult rat
23. A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei
24. Decrease in adrenergic axon sprouting in the senescent rat
25. Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal
26. Mechanisms of functional recovery following lesions of visual cortex or superior colliculus in neonate and adult hamsters
27. Quantitative autoradiographic analysis of the time course of proliferation of contralateral entorhinal efferents in the dentate gyrus denervated by ipsilateral entorhinal lesions
28. The process of reinnervation in the dentate gyrus of the adult rat: a quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis