Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

The Journal of Pathology

Volumn 142, Issue 1, 1984, Pages 67-77

  Wyllie, A H ^a   Morris, R G ^a   Smith, A L ^a   Dunlop, D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Apoptosis; endogenous endonuclease; glucocorticoid receptors

Indexed keywords

CYCLOHEXIMIDE; DACTINOMYCIN;

ANIMAL EXPERIMENT; APOPTOSIS; CHROMATIN; ELECTRON MICROSCOPY; LYMPHATIC SYSTEM; LYMPHOID CELL LINE; MACROMOLECULE; MOUSE; NONHUMAN; RAT; THYMOCYTE; THYMUS;

EID: 0021346318     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1711420112     Document Type: Review

References (47)

1. Apoptosis: a basic biological phenomenon with wide‐ranging implications in tissue kinetics
2. Cell death: the significance of apoptosis
3. Cell death: a new classification separating apoptosis from necrosis
4. Alterations in renal cortex following ischemic injury III. Ultrastructure of proximal tubules after ischemia or autolysis
5. Ischemic tissue injury
6. Cell death and the disease process. The role of calcium
7. Cell injury
8. Inhibitory effect of actinomycin D on tail atrophy in Xenopus larvae at metamorphosis
9. Requirement for RNA and protein synthesis for induced regression of tadpole tail in organ culture
10. A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard or X‐irradiation
11. Protective effects of an inhibitor of protein synthesis, cycloheximide, on bone marrow damage induced by cytosine arabinoside or nitrogen mustard
12. Inhibition of palatal epithelial cell death by altered protein synthesis
13. Cyclic AMP and tumor growth in vivo.
14. Methods for assessing hormone‐receptor kinetics with cells in suspension: a receptor bound and non‐specifically bound hormone; cytoplasmic‐nuclear translocation
15. Genetic analysis of glucocorticoid action in neoplastic lymphoid cells
16. Hormone‐induced cell death. Purification and properties of thymocytes undergoing apoptosis after glucocorticoid treatment
17. A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
18. Simian virus 40 deoxyribonucleic acid synthesis: analysis by gel electrophoresis
19. Chromatin changes in apoptosis
20. Metabolic and ultrastructural aspects of the in vitro lysis of chronic lymphocytic leukemia cells by glucocorticoids
21. Glucocorticoid‐induced thymocyte apoptosis is associated with endogenous endonuclease activation
22. Glucocorticoid‐induced proteins in rat thymus cells
23. Independence of the lethal action of glucocorticoids on lymphoid cells from possible hormone effects on calcium uptake
24. Calcium and A23187‐induced cytolysis of mouse thymocytes
25. Prevention by chlorpromazine of ischemic liver cell death
26. Calcium dependence of toxic cell deaths: a final common pathway
27. The role of calcium in cell death
28. Role of phospholipid hydrolysis in the mechanism of toxic cell death by calcium and ionophore A23187
29. Ultrastructural changes in lymphocytes exposed to noxious agents in vitro
30. DNA in chromatin of irradiated lymphoid tissues degrades in vivo into regular fragments
31. Evidence for the internucleosomal breakage of chromatin in rat thymocytes irradiated in vitro
32. Characteristics of rat thymus chromatin degradation products after whole body X‐irradiation
33. DNA repair in thymus lymphocytes after irradiation
34. Radiation‐induced free polydeoxynucleotides in lymphoid tissues: a product of the action of neutral deoxyribonuclease (DNAse I)
35. Early glucocorticoid‐dependent stimulation of RNA polymerase B in rat thymus cells
36. Regulation of transcription in rat thymus cells by glucocorticoids
37. Effect of gamma‐irradiation on DNA‐dependent RNA polymerase activity in rat thymus cells
38. The induction of gene activity in Drosophila by heat shock
39. In vitro synthesis of heat‐shock proteins by mRNAs from chicken fibroblasts
40. Heat‐shock‐induced alterations of ribosomal protein phosphorylation in plant cell cultures
41. A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes
42. The spontaneous occurrence of apoptosis in squamous carcinomas of the uterine cervix
43. An electron microscopic study of cell degeneration in chick embryo spinal ganglia
44. Cytochemical analysis of organelle degradation in phagosomes and apoptotic cells of the mucoid epithelium of mice
45. Mammalian endonuclease, DNase V. Purification and properties of enzyme of calf thymus
46. Purification and properties of a mammalian endonuclease showing site‐specific cleavage of DNA
47. 2+‐dependent endodeoxyribonuclease from calf thymus chromatin