DOUBLE-BLIND STUDY OF γ-VINYL GABA IN PATIENTS WITH REFRACTORY EPILEPSY

The Lancet

Volumn 323, Issue 8370, 1984, Pages 189-190

  Rimmer, ElizabethM ^a   Richens, Alan ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; PHENYTOIN; PLACEBO; VIGABATRIN;

ADVERSE DRUG REACTION; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG BLOOD LEVEL; DRUG INTERACTION; DRUG THERAPY; EPILEPSY; HUMAN; INTOXICATION; MOOD; NERVOUS SYSTEM; NEUROTOXICITY; ORAL DRUG ADMINISTRATION; SERUM; THERAPY;

4-AMINOBUTYRATE TRANSAMINASE; ADOLESCENT; ADULT; AMINOCAPROIC ACIDS; CLINICAL TRIALS; DOUBLE-BLIND METHOD; EPILEPSY; FEMALE; HUMAN; MALE; MIDDLE AGE; RANDOM ALLOCATION; SUPPORT, NON-U.S. GOV'T; VIGABATRIN;

EID: 0021342744     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(84)92112-3     Document Type: Article

References (15)

1. Epilepsy and gamma-aminobutyric acid mediated inhibition
2. Neurotransmitters and epilepsy
3. The role of GABA mediated neurotransmission in convulsive states
4. Gamma aminobutyric acid and the search for new anticonvulsant drugs
5. Neurotransmitters and CNS disease, Epilepsy
6. Suicide enzyme inhibitors as potential drugs
7. Suicide inhibitors of GABA-transaminase
8. γ-vinyl GABA (4-aminohex-5-enoic acid) a new selective irreversible inhibitor of GABA-transaminase effects on brain GABA metabolism in mice
9. Effect of γ-vinyl GABA on bicuculline induced seizures
10. Attempts to correlate alterations in brain GABA metabolism by GABA-T inhibitors with their anticonvulsant effects
11. Biochemical and pharmacological similarities and differences among four irreversible enzyme-activated GABA-T inhibitors
12. Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, γ-acetylenic GABA (4-amino-hex-5-ynoic acid) and γ-vinyl GABA (4-amino-hex-5-enoic acid)
13. Increased gamma-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid)
14. The relationship between GABA concentrations in brain and cerebrospinal fluid