Inhibition by azelastine of nonallergic histamine release from rat peritoneal mast cells

The Journal of Allergy and Clinical Immunology

Volumn 73, Issue 3, 1984, Pages 400-403

  Fields, Dorothy A S ^a   Pillar, John ^a   Diamantis, William ^a   Perhach Jr , James L ^a   Sofia, R Duane ^a   Chand, Naresh ^a  

^a Wallace Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; AZELASTINE; COMPOUND 48-80; CONCANAVALIN A; CROMOGLYCATE DISODIUM; KETOTIFEN; THEOPHYLLINE;

ALLERGY; ANIMAL CELL; HISTAMINE RELEASE; MAST CELL; NONHUMAN; PERITONEUM; PERITONEUM MAST CELL; RAT; RETICULOENDOTHELIAL SYSTEM;

ANIMALS; CONCANAVALIN A; HISTAMINE H1 ANTAGONISTS; HISTAMINE RELEASE; MALE; MAST CELLS; P-METHOXY-N-METHYLPHENETHYLAMINE; PHOSPHATIDYLSERINES; PHTHALAZINES; PYRIDAZINES; RATS; RATS, INBRED STRAINS;

EID: 0021329146     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-6749(84)90415-9     Document Type: Article

References (14)

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6. Inhibition of calcium ionophore (A23187)-induced histamine release by a novel anti-allergic agent, 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepine-4yl)-1(2H)-phthalazinone hydrochloride (azelastine: A5610)
7. 1 antagonist-antiallergic agent
8. Inhibition by azelastine of the immunologically-induced histamine release from isolated guinea pig mast cells
9. Studies on mechanisms of hypersensitivity phenomena. IX. Histamine release from human leukocytes by ragweed pollen antigen
10. A method for the fluorometric assay of histamine in tissues
11. The pharmacological control of immediate hypersensitivity
12. Inhibition of allergic histamine secretion from rat peritoneal mast cells (RPMC) by azelastine, a novel, orally acting antiallergic agent
13. Inhibition of secretagogue-induced histamine release from rat peritoneal mast cells in vitro by a novel antiallergic agent, 4-(p-chlorobenzyl)-2-(hexahydro-1 methyl-1H-azepine-4yl)-1(2H)-phthalazinone hydrochloride (azelastine)
14. Inhibition of calcium ionophore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastine: Implications for its mode of action