Heterogeneity in the molecular basis of three types of hereditary persistence of fetal hemoglobin and the relative synthesis of the Gγ and Aγ types of γ chain

Biochemical Genetics

Volumn 22, Issue 1-2, 1984, Pages 21-35

  Kutlar, A ^a,b   Gardiner, M B ^a,b   Headlee, M G ^a,b   Reese, A L ^a,b   Cleek, M P ^a,b   Nagle, S ^a,b   Sukumaran, P K ^a,b   Huisman, T H J ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

G :A ratio; different types of HPFH; DNA; family data; hereditary persistence of fetal hemoglobin; in vitro chain synthesis; restriction endonucleases

Indexed keywords

HEMOGLOBIN F; HEMOGLOBIN GAMMA CHAIN; RADIOISOTOPE;

BLOOD AND HEMOPOIETIC SYSTEM; CONGENITAL DISORDER; DNA PROBE; ETIOLOGY; FAMILY; GENETIC ENGINEERING; GENETIC HETEROGENEITY; HEMOGLOBIN F PERSISTENCE; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; RESTRICTION MAPPING;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CHILD; DNA; DNA RESTRICTION ENZYMES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FETAL HEMOGLOBIN; GENES; HEMOGLOBINOPATHIES; HETEROZYGOTE; HUMANS; INDIA; MACROMOLECULAR SUBSTANCES; MALE; PEDIGREE;

EID: 0021323996     PISSN: 00062928     EISSN: 15734927     Source Type: Journal    
DOI: 10.1007/BF00499284     Document Type: Article

References (26)

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4. The Negro variety of hereditary persistence of fetal hemoglobin is a mild form of thalassemia
5. Gamma-chain heterogeneity of fetal hemoglobin in nonblack β- and δβ-thalassemia and HPFH heterozygotes and homozygotes
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13. Quantitation of three types of γ chain of Hb F by high pressure liquid chromatography; Application of this method to the Hb F of patients with sickle cell anemia or the S-HPFH condition
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15. Sequencing end-labeled DNA with base-specific chemical cleavage
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