2-Substituted thiazolidine-4(E)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

Journal of Medicinal Chemistry

Volumn 27, Issue 5, 1984, Pages 591-596

  Nagasawa, Herbert T ^a   Goon, David J W ^a   Muldoon, William P ^a   Zera1, Richard T ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 4 THIAZOLIDINECARBOXYLIC ACID; CYSTEINE; NEW DRUG; PARACETAMOL; PRODRUG; PROLINE DEHYDROGENASE; RADIOISOTOPE; TIMONACIC; TIMONACIC DERIVATIVE;

2 METHYL 4 THIAZOLIDINECARBOXYLIC ACID C 14; 2 PENTYL 4 THIAZOLIDINECARBOXYLIC ACID; 2 PROPYL 4 THIAZOLIDINECARBOXYLIC ACID; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ANALYSIS; DRUG ANTAGONISM; DRUG COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG MONITORING; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; FATALITY; HISTOLOGY; INTOXICATION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LIVER TOXICITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PREVENTION; RAT; TIMONACIC C 14;

ACETAMINOPHEN; ANIMAL; CARBON RADIOISOTOPES; CYSTEINE; INDICATORS AND REAGENTS; KINETICS; LIVER; MALE; MICE; MITOCHONDRIA, LIVER; PROLINE OXIDASE; RATS; RATS, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, NON-P.H.S.; THIAZOLES;

EID: 0021319807     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00371a006     Document Type: Article

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