Preparation of liposomes containing factor VIII for oral treatment of haemophilia

Journal of Microencapsulation

Volumn 1, Issue 1, 1984, Pages 33-45

  Kirby, Christopher J ^a   Gregoriadis, Gregory ^a  

^a MRC Clinical Research Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DISTEAROYLLECITHIN; 1,2-DISTEAROYLLECITHIN; BLOOD CLOTTING FACTOR 8; DRUG CARRIER; LIPOSOME; PHOSPHATIDYLCHOLINE;

ANIMAL; ARTICLE; DOG; DRUG FORMULATION; HEMOPHILIA A; METHODOLOGY; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMAL; DOGS; DRUG CARRIERS; DRUG COMPOUNDING; FACTOR VIII; HEMOPHILIA A; LIPOSOMES; PHOSPHATIDYLCHOLINES;

EID: 0021289602     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.3109/02652048409031535     Document Type: Article

References (21)

1. Orally administered liposome-entrapped insulin in diabetic animals
2. Studies on the nature of the circulating anticoagulant directed against anti-haemophilic factor: with notes on an assay for antihaemophilic factor
3. Hypoglycaemic effect of liposome-entrapped insulin administered intragastrically into rats
4. The effect of liposomal lipid concentration on the fate of liposome-entrapped insulin and tubocurarine
5. Can intact liposomes be absorbed in the gut?
6. Targeting of drugs: Implications in medicine
7. Oral treatment of haemophilia A by gastrointestinal absorption of Factor VIII entrapped in liposomes
8. Oral-administration of Factor VIII in lipid vesicles
9. Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and vitro
10. A simple procedure for preparing liposomes capable of high encapsulation efficiency under mild conditions
11. Incorporation of Factor VIII into liposomes
12. Human factor VIII procoagulant activity and phospholipid interaction
13. Encapsulation of angiotensin II in liposomes: Characterization in vitro and in vivo
14. Oral administration of insulin by encapsulation within liposomes
15. Immunologic studies of Factor VIII coagulant activity assays based on a haemophilic and an acquired antibody to VIII: C
16. The stability of liposomes in vitro to pH, bile salts and pancreatic lipase
17. A model for the oral administration of peptide hormones
18. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation
19. Oral administration of liposomally-entrapped heparin to beagle dogs