Opposite effects of an agonist, R05-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice

Life Sciences

Volumn 34, Issue 26, 1984, Pages 2613-2620

  Benavides J ^a   Guilloux, F ^a   Allam, D E ^a   Uzan, A ^a   Mizoule, J ^a   Renault, C ^a   Dubroeucq, M C ^a   Gueremy C ^a   Le Fur, G ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE; BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; CLONAZEPAM; FLUNITRAZEPAM H 3; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE H 3; NEW DRUG; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; CENTRAL NERVOUS SYSTEM; DOSE RESPONSE; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG RESPONSE; EPILEPSY; MOUSE; NONHUMAN; PHARMACOKINETICS;

ACOUSTIC STIMULATION; ANIMALS; BENZODIAZEPINONES; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOQUINOLINES; MALE; MICE; MICE, INBRED DBA; RECEPTORS, CELL SURFACE; RECEPTORS, GABA-A; SEIZURES;

ANIMALIA;

EID: 0021264024     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(84)90048-1     Document Type: Article

References (20)

1. Ro 5-4864: A potent benzodiazepine convulsant