Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2, 5,6-tetrahydropyridine by monoamine oxidase inhibitors

Nature

Volumn 311, Issue 5985, 1984, Pages 467-469

  Heikkila, Richard E ^a   Manzino, Lawrence ^a   Cabbat, Felicitas S ^a   Duvoisin, Roger C ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CLORGYLINE; DOPAMINE; MONOAMINE OXIDASE INHIBITOR; NIALAMIDE; PARGYLINE; RADIOISOTOPE; SELEGILINE; TRANYLCYPROMINE;

ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; DOPAMINE H 3; DRUG ANTAGONISM; DRUG EFFICACY; INTOXICATION; MOUSE; NERVOUS SYSTEM; NEUROTOXICITY; NONHUMAN; PERIPHERAL NERVOUS SYSTEM;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 3,4-DIHYDROXYPHENYLACETIC ACID; ANIMAL; BIOTRANSFORMATION; CORPUS STRIATUM; DOPAMINE; HOMOVANILLIC ACID; MALE; MICE; MONOAMINE OXIDASE INHIBITORS; NEURONS; PYRIDINES; SUBSTANTIA NIGRA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0021224694     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/311467a0     Document Type: Article

References (12)

1. Davis, G. C. et al Psychol Res., 1, 249-254 (1979).
2. Langston, J. W., Ballard, P., Tetrud, J. W. & Irwin, I. Science 219, 979-980 (1983).
3. Burns, R. S. et al. Proc. natn. Acad. Sci U.S.A 80, 4546-4550 (1983).
4. Langston, J, W., Forno, L. S., Rebert, C. S. & Irwin, I. Brain Res., 292, 390-394 (1984).
5. Heikkila, R. E., Cabbat, F. S., Manzino, L. & Duvoisin, R. C, Fedrt Proc., 43, 743 (1984).
6. Heikkila, R. E., Hess, A. & Duvoisin, R. C. Science 224, 1451 (1984).
7. Hallman, H., Olson, L. & Jonsson, G. Eur. J. Pharmac., 97, 133-136 (1984).
8. Markey, S. P., Johannessen, J. N., Chiueh, C. C., Burns, R. S. & Herkenham, M. A. American College of Neuropsychopharmacology Meeting, Abstr., 69 (1983).
9. Chiba, K., Trevor, A. & Castagnoli, N. Biochem. biophys. Res. Commun., 120, 574-578 (1984).
10. Neff, N. H. & Goridis, C. Adv. Biochem. Psychopharmac., 5, 307-323 (1972).
11. Mayer, G. S. & Shoup, R. E. J. Chromatogr., 255, 533-544 (1983).
12. Gershanik, O., Heikkila, R. E. & Duvoisin, R. C. Brain Res., 261, 358-360 (1983).