Luteinizing hormone-releasing hormone binds to enriched human placental membranes and stimulates in vitro the synthesis of bioactive human chorionic gonadotropin

Journal of Clinical Endocrinology and Metabolism

Volumn 59, Issue 1, 1984, Pages 119-126

  Belisle, Serge ^a   Guevin, Jean Francois ^b   Bellabarba, Diego ^c   Lehoux, Jean Guy ^b  

^a Departments of Obstetrics Gynecology ^*  (Canada)

^b UNIVERSITY OF SHERBROOKE   (Canada)

^c Department of Medicine ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BUSERELIN; CHORIONIC GONADOTROPIN; GONADORELIN; GONADORELIN DERIVATIVE; OXYTOCIN; PROTIRELIN; RADIOISOTOPE;

CELL MEMBRANE; DRUG RECEPTOR BINDING; ELECTRON MICROSCOPY; GONADORELIN I 125; HUMAN; HUMAN CELL; NORMAL HUMAN; PHARMACOKINETICS; PLACENTA; PREGNANCY;

CELL MEMBRANE; CENTRIFUGATION, DENSITY GRADIENT; CHORIONIC GONADOTROPIN; FEMALE; GONADORELIN; HUMAN; IN VITRO; MICROSCOPY, ELECTRON; PLACENTA; PREGNANCY; RECEPTORS, CELL SURFACE; RECEPTORS, LHRH; SUPPORT, NON-U.S. GOV'T; TEMPERATURE;

EID: 0021223405     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-59-1-119     Document Type: Article

References (35)

1. Gibbons JM, Mitnick M, Chieffo V 1975 In vitro biosynthesis of TSH- and LH-releasing factors by the human placenta. Am J Obstet Gynecol 121:127
2. Tan L, Rousseau P 1982 The chemical identity of the immunoreactive LHRH-like peptide biosynthesized in the human placenta. Biochem Biophys Res Commun 109:1061
3. Siler-Khodr TM, Khodr GS 1978 Content of luteinizing hormonereleasing factor in the human placenta. Am J Obstet Gynecol 130:216
4. Khodr GS, Siler-Khodr TM 1980 Placental luteinizing hormonereleasing factor and its synthesis. Science 207:315
5. Khodr GS, Siler-Khodr TM 1978 Localization of luteinizing hormone- releasing factor in the human placenta. Fertil Steril 29:523
6. Khodr GS, Siler-Khodr TM 1978 The effect of luteinizing hormone- releasing factor on human chorionic gonadotropin secretion. Fertil Steril 30:301
7. Akira M, Tetsuro S, Toshihiro A, Yasuhiro K, Toshihiro M, Keiighi K 1982 Changes in luteinizing hormone-releasing hormone in human placenta throughout pregnancy. Obstet Gynecol 60:444
8. Siler-Khodr TM, Khodr GS 1981 Dose response analysis of GNRH stimulation of hCG release from human term placenta. Biol Reprod 25:353
9. Siler-Khodr TM, Khodr GS, Vickery BH, Nestor Jr JJ 1983 Inhibition of hCH, αhCG, and progesterone release from human placental tissue in vitro by a GNRH antagonist. Life Sci 32:2641
10. Siler-Khodr 1983 Hypothalamic-like releasing hormones of the placenta. Symposium on Perinatal Endocrinology. Clin Perinatol 10:553
11. Siler-Khodr TM, Khodr GS 1983 Gonadotropin releasing hormone (GNRH) in the placenta. In: McCann SM (ed) The Role of Peptides and Proteins in Control of Reproduction. Elsevier/North- Holland, Inc, New York, p 347
12. Currie AJ, Fraser HM, Sharpe RM 1981 Human placental receptors for luteinizing hormone releasing hormone. Biochem Biophys Res Commun 99:332
13. Salacinski PRP, McLean C, Sykes JEC, Clement-Jones VV, Lowry PJ 1981 Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetracholoro-3α, 6α-Diphenyl Glycoluril (Iodogen). Anal Biochem 117:136
14. Escher EA 1983 Rapid and simple iodine labelling and HPLCpurification of peptides hormones. In: Duncan WP, Susan AB (eds) Synthesis and Applications of Isotopically Labelled Compounds. Elsevier Scientific Publishing Co, Amsterdam, p 231
15. Emmelot P, Bos CJ 1966 Studies on plasma membranes. II. K dependent ρ-nitrophenyl phosphatase activity of plasma membranes isolated from rat liver. Biochem Biophys Acta 121:375
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ 1951 Protein measurement with the Folin phenol reagent. J Biol Chem 193:265
17. Burton K 1956 A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62:315
18. Hall C, James TE, Goodyer C, Branchaud C, Guyda H, Groud CJP 1977 Sort term tissue culture of human mid-term and term placenta. Parameters of hormonogenesis. Steroids 30(4):569
19. Rodbard D 1973 Mathematics of hormone-receptor interaction. I. Basic principles. Adv Exp Med Biol 36:289
20. Chamness G, McGuire WL 1975 Scatchard plots: common errors in correction and interpretation. Steroids 26:538
21. Gale JS, Wakefield J, Ford HC 1982 Isolation of rat Leydig cells by density gradient centrifugation. J Endocrinol 92:293
22. Carlson RW, Wada HG, Sussman HH 1976 The plasma membrane of the human placenta. Isolation of microvillus membrane and characterization of protein and glycoprotein subunits. J Biol Chem 251:4139
23. Smith CH, Nelson DM, King BF, Donohue TM, Ruzycki SM, Kelley LK 1977 Characterization of a microvillus membrane preparation from human placental syncytiotrophoblast: a morphologic, biochemical and physiological study. Am J Obstet Gynecol 128:190
24. Whitsett JA, Lessard JL 1978 Characteristics of the microvillus brush border of human placenta: insulin receptor localization in brush border membranes. Endocrinology 103:1458
25. Alsat E, Bovali Y, Goldstein S, Malassine A, Laudat MH, Gedard L 1982 Characterization of specific low-density lipoprotein binding sites in human term placental microvillus membranes. Mol Cell Endocrinol 28:439
26. Marian J, Conn PM 1983 Subcellular localization of the receptor for gonadotropin-releasing hormone in pituitary and ovarian tissue. Endocrinology 112:104
27. Clayton RM, Catt KJ 1981 Gonadotropin releasing hormone receptors: characterization, physiological regulation, and relationship to reproductive function. Endocr Rev 2:186
28. Conne BS, Aubert ML, Sizomemko PC 1979 Quantification of pituitary membrane receptor sites to LHRH: use of a superactive analog as tracer. Biochem Biophys Res Commun 90:1249
29. Popkin R, Bramley TA, Currie A, Shaw RW, Baird DT, Fraser HM 1983 Specific binding of luteinizing hormone releasing hormone to human luteal tissue. Biochem Biophys Res Commun 114:750
30. Marshall JC, Shakespear RH, Odell WD 1976 LHRH pituitary plasma membrane binding: the presence of specific binding sites in other tissues. Clin Endocrinol (Oxf) 5:671
31. Clayton RN, Shakespear RH, Marshall JC 1978 LHRH binding to purified pituitary plasma membranes: absence of adenylate cyclase activation. Mol Cell Endocrinol 11:63
32. Grant G, Vale W, Rivier J 1973 Pituitary binding sites for [3H] labelled luteinizing hormone releasing factor. Biochem Biophys Res Commun 50:771
33. Spona J 1973 LHRH stimulated gonadotropin release mediated by two distinct pituitary receptors. FEBS Lett 35:59
34. Humphries J, Wan YP, Folkers K 1978 Inhibitory analogues of the luteinizing hormone-releasing hormone having D-aromatic residues in positions 2 and 6 and variation in position 3. J Med Chem 21:120
35. Osathanondh R, Tulchinsky D 1980 Placental polypeptide hormones. In: Tulchinsky D, Ryan KJ (eds) Maternal - Fetal Endocrinology. WB Saunders Company, pp 19-22