Disposition and Metabolism of Metronidazole in Patients with Liver Failure

Hepatology

Volumn 4, Issue 4, 1984, Pages 722-726

  Farrell, Geoffrey ^a   Baird‐Lambert, Judith ^a   Cvejic, Mara ^a   Buchanan, Neil ^a  

^a Paediatric Pharmacology Unit ^*  (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

METRONIDAZOLE;

DOSE KIDNEY FUNCTION RELATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; LIVER FAILURE; METHODOLOGY; PHARMACOKINETICS; THERAPY;

ADULT; AGED; ASCITIC FLUID; FEMALE; HUMAN; HYDROXYLATION; KIDNEY; KINETICS; LIVER DISEASES; MALE; METRONIDAZOLE; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T;

EID: 0021217944     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.1840040427     Document Type: Article

References (12)

1. Metronidazole
2. The isolation and identification of the urinary oxidative metabolites of metronidazole in man
3. Biliary and renal excretion, hepatic metabolism, and hepatic subcellular distribution of metronidazole in the rat
4. Metronidazole in renal failure
5. The pharmacokinetics of metronidazole in patients with chronic renal failure
6. Rectal administration of metronidazole provides therapeutic plasma levels in post‐operative patients
7. Impaired metronidazole elimination in decompensated chronic liver disease
8. Spironolactone and enzyme induction in patients with alcoholic cirrhosis
9. A rapid and specific semimicro method involving high pressure liquid chromatography for the assay of metronidazole in plasma, saliva, serum, urine and whole blood
10. Pharmacokinetics of intravenous metronidazole in man
11. Normal disposition of oxazepam in acute viral hepatitis and cirrhosis
12. Preservation of glucu‐ronidation in carbon tetrachloride‐induced acute liver injury in the rat