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Volumn 25, Issue 26, 1984, Pages 2821-2822

The synthesis of E-(2s, 3s)-3-trimethylsilylglycidol and its conversion to (-)-propranolol

Author keywords

[No Author keywords available]

Indexed keywords

PROPRANOLOL;

EID: 0021196096     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(01)81299-5     Document Type: Article
Times cited : (45)

References (8)
  • 6
    • 84918063298 scopus 로고    scopus 로고
    • Epoxy alcohol 2 was sensitive to acid. The improved work-up procedure shown below was essential to isolate 2. After the reaction was completed, the reaction mixture was poured into a solution of acetonitrile and water saturated with NaF (1:1). The mixture was stirred for 1h at room temperature and extracted with dichloromethane. The organic layer was dried and concentrated. The residue was chromatographed on silica gel to give 2. Another improved procedure has been reported


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