Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation

FEBS Letters

Volumn 173, Issue 2, 1984, Pages 287-290

  Gut, J ^a   Gasser, R ^a   Dayer, P ^a   Kronbach, T ^a   Catin, T ^a   Meyer, U A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN; BENZPHETAMINE; BUFURALOL; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; DEBRISOQUINE; ISOENZYME;

DRUG ANALYSIS; DRUG IDENTIFICATION; DRUG INTERACTION; DRUG ISOLATION; DRUG METABOLISM; DRUG PURIFICATION; DRUG SCREENING; HEREDITY; HUMAN; HUMAN CELL; KIDNEY; LIVER; NORMAL HUMAN;

ADRENERGIC BETA-ANTAGONISTS; CYTOCHROME P-450 ENZYME SYSTEM; DEBRISOQUIN; ETHANOLAMINES; HUMANS; HYDROXYLATION; ISOENZYMES; ISOQUINOLINES; KINETICS; MICROSOMES, LIVER; MOLECULAR WEIGHT; OXIDATION-REDUCTION; POLYMORPHISM, GENETIC; SUBSTRATE SPECIFICITY;

EID: 0021164360     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(84)80792-9     Document Type: Article

References (20)

1. POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN
2. Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine.