An effective and convenient route to 5-trifluoromethyl-5,6-dihydrouracils and their thio derivatives

Synthesis (Germany)

Volumn 1984, Issue 9, 1984, Pages 766-768

  Fuchikami, Takamasa ^a   Yamanouchi, Akiko ^b   Ojima, Iwao ^a  

^a SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 5 TRIFLUOROMETHYLURACIL; 5,6 DIHYDRO 5 TRIFLUOROMETHYLURACIL DERIVATIVE; NEW DRUG; THIOURACIL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST; CELL STRAIN MM2; DRUG ANALYSIS; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; INFRARED SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRELIMINARY COMMUNICATION; THERAPY;

EID: 0021130585     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-1984-30964     Document Type: Article

References (5)

1. R. Filler, S. M. Nagvi, in: Biomedical Aspects of Fluorine Chemistry, R. Filler, Y. Kobayashi, Eds., Elsevier Biomedical Press, Amsterdam, 1982, p. 1-32.
2. T. Fuchikami, I. Ojima, Tetrahedron Lett. 23, 4099 (1982).
3. C. Heidelberger, D, Parsons. D.C. Remy, .J. Med. Chem. 7, 1 (1964).
4. M.W. Buxton, M. Stacy, JX. Tatlow, J. Chem. Soc. 1954, 366.
5. F.G. Drakesmith, O.J. Stewart, P. Tarrant, J. Org. Chem. 33, 280 (1967).