Neurovirulence of herpes simplex virus type 1 depends on age in mice and thymidine kinase expression

Archives of Virology

Volumn 78, Issue 3-4, 1983, Pages 303-308

  Ben Hur, T ^a   Hadar, Julia ^a   Shtram, Y ^a   Gilden, D H ^a   Becker, Y ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDINE KINASE;

AGE; ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; EXPERIMENTAL INFECTION; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; MAJOR CLINICAL STUDY; MOUSE; NEUROVIRULENCE; NONHUMAN; VIRUS MUTATION;

AGING; ANIMALS; BRAIN; HERPES SIMPLEX; MICE; NERVOUS SYSTEM DISEASES; SIMPLEXVIRUS; THYMIDINE KINASE; TRIGEMINAL GANGLION; VIRULENCE;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1;

EID: 0021092363     PISSN: 03048608     EISSN: 14328798     Source Type: Journal    
DOI: 10.1007/BF01311326     Document Type: Article

References (23)

1. The HSV-1 thymidine kinase gene controls expression in eukaryotic and prokaryotic cells and viral pathogenesis in mice
2. Initial herpes simplex virus type 1 infection prevents ganglionic superinfection by other strains
3. Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammalian cells
4. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)-guanine
5. Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo
6. Isolation and characterization of acyclovir-resistant mutants of herpes simplex virus
7. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice
8. Recurrent herpes simplex: the outlook for systemic antiviral agents
9. A low thymidine kinase-producing mutant of herpes simplex virus type 1 causes latent trigeminal ganglia infections in mice
10. Pathogenesis of experimental skin infections induced by drug-resistant herpes simplex virus mutants
11. Protection of neonatal mice against herpes simplex infection: probably in vivo antibody-dependent cellular cytotoxicity
12. Low virulence and immunogenicity in mice and in rabbits of variants of herpes simplex virus resistant to 5-iodo-2-deoxyuridine
13. Herpetic ganglionic latency. Acyclovir and vidarabine therapy
14. Resistance of peripheral autonomic neurons to in-vivo productive infection by herpes simplex virus mutants deficient of TK activity
15. Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci
16. Protection of mice by an apathogenic strain of HSV-1 against lethal infection by a pathogenic strain of HSV-1
17. Thymidine kinase in the developing rat brain
18. Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion
19. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus
20. Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation
21. Effect of thyroxine on DNA synthesis and thymidine kinase activity during cerebellar development
22. Changes of thymidine kinase in the developing rat brain
23. Experimental infection of inbred mice with herpes simplex virus. III. Comparison between newborn and adult C 57 BL/6 mice