Estimation of biologically active intact parathyroid hormone in normal and hyperparathyroid sera by sequential n-terminal immunoextraction and midregion radioimmunoassay

Journal of Clinical Endocrinology and Metabolism

Volumn 57, Issue 5, 1983, Pages 1007-1014

  Lindall, A W ^a   Elting, J ^a   Ells, J ^a   Roos, B A ^b  

^a Immuno Nuclear Corporation ^*  (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE;

CATTLE; DIAGNOSIS; ENDOCRINE SYSTEM; HYPERPARATHYROIDISM; IMMUNOEXTRACTION; KIDNEY; KIDNEY DISEASE; METHODOLOGY; NONHUMAN; PATIENT; RADIOIMMUNOASSAY; SERUM;

ADOLESCENT; ADULT; AGED; ANIMAL; BIOLOGICAL ASSAY; CHROMATOGRAPHY, AFFINITY; COMPARATIVE STUDY; CYCLIC AMP; HUMAN; HYPERPARATHYROIDISM; IMMUNE SERA; IMMUNOLOGIC TECHNIQUES; KIDNEY FAILURE, CHRONIC; MIDDLE AGE; OSTEOSARCOMA; PARATHYROID HORMONES; PEPTIDE FRAGMENTS; RADIOIMMUNOASSAY; RATS;

EID: 0021090334     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-57-5-1007     Document Type: Article

References (47)

1. Lindall AW, Wong ET 1975 Column chromatography of human serum parathyroid immunoreactive peptides. Proc Soc Exp Biol Med 148:799
2. Wong ET, Lindall AW 1975 Subcellular localization of human parathyroid hormone immunoreactive peptides. Proc Soc Exp Biol Med 148:387
3. Reiss E, Canterbury JM 1974 Emerging concepts of the nature of circulating parathyroid hormones: implications for clinical research. Recent Prog Horm Res 30:391
4. Segre GV, Habener JF, Powell D, Tregear GW, Potts Jr JT 1972 Parathyroid hormone in human plasma: immunological characterization and biological implications. J Clin Invest 51:3163
5. Martin KJ, Hruska KA, Freitag JJ, Klahr S, Slatopolsky E 1979 The peripheral metabolism of parathyroid hormone. N Engl J Med 301:1092
6. Morrissey JJ, Hamilton JW, MacGregor RR, Cohn DV 1980 The secretion of parathormone fragments 34-84 and 37-84 by dispersed porcine parathyroid cells. Endocrinology 107:164
7. Canterbury JM, Reiss E 1972 Multiple immunoreactive forms of parathyroid hormone in human sera. Proc Soc Exp Biol Med 140:1393
8. Sherman LM, Herrman I, Bassett CA 1969 In vitro studies of normal and abnormal parathyroid tissue. Arch Intern Med 124:426
9. Flueck JA, DiBella FP, Edis AJ, Kehrwald IM, Arnaud CD 1977 Immunoheterogeneity of parathyroid hormone in venous effluent serum from hyperfunctioning parathyroid glands. J Clin Invest 60:1367
10. Habener JF 1981 Recent advances in parathyroid hormone research. Clin Biochem 14:223
11. Parthemore JG, Roos BA, Parker CD, Kripke DF, Avioli LV, Deftos LJ 1978 Assessment of acute and chronic changes in parathyroid hormone secretion by a radioimmunoassay with predominant specificity for the carboxy-terminal region of the molecule. J Clin Endocrinol Metab 47:284
12. Roos BA, Deftos LJ 1979 Parathyroid hormone radioimmunoassay. In: Behrman HR, Jaffe BM (eds) Methods of Hormone Radioimmunoassay, ed 2. Academic Press, New York, p 401
13. Roos BA, Lindall AW, Aron DC, Orf JW, Yoon M, Huber MB, Pensky J, Ells J, Lambert PW 1981 Detection and characterization of small midregion parathyroid hormone fragment(s) in normal and hyperparathyroid glands and sera by immunoextraction and region-specific radioimmunoassays. J Clin Endocrinol Metab 53:709
14. Lindall AW, Roos BA, Cecchettin M 1981 Potential clinical usefulness of new glandular and circulating parathyroid peptides illuminated by sequence specific radioimmunoassay. In: Albertini A, Ekins R (eds) Monoclonal Antibodies and Developments in Immunoassay. Elsevier/North Holland Biomedical Press, Amsterdam, p 227
15. Marx SJ, Sharp ME, Krudy A, Rosenblatt M, Mallette LE 1981 Radioimmunoassay for the middle region of human parathyroid hormone: studies with a radioiodinated synthetic peptide. J Clin Endocrinol Metab 53:76
16. Mallette LE, Tuma SN, Berger RE, Kirkland JL 1982 Radioimmunoassay for the middle region of human parathyroid hormone using an homologous antiserum with a carboxy-terminal fragment of bovine parathyroid hormone as radioligand. J Clin Endocrinol Metab 54:1017
17. Kao PC, Jiang N-S, Klee GG, Purnell DC 1982 Development and validation of a new radioimmunoassay for parathyscin (PTH). Clin Chem 28:69
18. Woo I, Singer FR 1974 Radioimmunoassay for human parathyroid hormone. Clin Chim Acta 54:161
19. Singer FR, Bethune JE, Massry SG 1977 Hypercalcemia and hypocalcemia. Clin Nephrol 7:154
20. Raisz LG, Yajnik CH, Bockman RS 1978 Discriminant analysis in differential diagnosis of hypercalcemia. Clin Endocrinol (Oxf) 8:349
21. Chambers DJ, Dunham J, Zanelli JM, Parsons JA, Bitensky L, Chayen J 1978 A sensitive bioassay of parathyroid hormone in plasma. Clin Endocrinol (Oxf) 9:375
22. Fenton S, Somers S, Heath DA 1978 Preliminary studies with the sensitive cytochemical assay for parathyroid hormone. Clin Endocrinol (Oxf) 9:381
23. Goltzman D, Henderson B, Loveridge N 1980 Cytochemical bioassay of parathyroid hormone. Characteristics of the assay and analyses of circulating hormonal forms. J Clin Invest 65:1309
24. Bennett HPJ, Browne CA, Goltzman D, Solomon S 1979 Isolation of peptide hormones by reversed-phase high pressure liquid chro matography. In: Gross B, Meienhofer J (eds) Proceedings of the Sixth American Peptide Symposium. Pierce Chemical Co., Rockford, p 121
25. Benson JR 1975 Some recent advances in amino acid analysis. In: Derham RN (ed) Instrumentation in Amino Acid Sequence Analysis. Academic Press, London
26. Edman P, Begg G 1967 A protein sequenator. Eur J Biochem 1:80
27. Edman P, Henschen A 1975 Sequence determination. In: Needleman SB (ed) Protein Sequence Determination. Springer Verlag, New York, p 235
28. MacGregor RR, Hamilton JW, Shofstall RE, Cohn DV 1979 Isolation and characterization of porcine parathyroid cathepsin B. J Biol Chem 254:4423
29. MacGregor RR, Hamilton JW, Kent GN, Shofstall RE, Cohn DV 1979 The degradation of proparathormone and parathormone by parathyroid and liver cathepsin B. J Biol Chem 254:4428
30. Keutmann HT, Sauer MM, Hendy GN, O'Riordan JLH, Potts Jr JT 1978 Complete amino acid sequence of human parathyroid hormone. Biochemistry 17:5723
31. Zanelli JM, Gaines Das RE 1980 International collaborative study on N.I.B.S.C. research standard for human parathyroid hormone for immunoassay. J Endocrinol 86:291
32. Mallette LE, Bradley WA 1981 Bovine parathyroid hormone-(41-84), a hormone fragment with desirable properties for use as radioligand. J Lab Clin Med 98:886
33. 131I-labeled human growth hormone of high specific radioactivity. Biochem J 89:114
34. Partridge NC, Alcorn D, Michelangeli VP, Kemp BE, Ryan GB, Martin TJ 1981 Functional properties of hormonally responsive cultured normal and malignant rat osteoblastic cells. Endocrinology 108:213
35. Gaddum JH 1953 Simplified mathematics for bioassay. J Pharm Pharmacol 5:345
36. Goldberg ML 1977 Radioimmunoassay for adenosine 3',5' cyclic monophosphate and guanosine 3',5' cyclic monophosphate in human blood, urine and cerebrospinal fluid. Clin Chem 23:576
37. Wood WG, Stalla G, Muller OA, Scriba PC 1979 A rapid and specific method for separation of bound and free antigen in radioimmunoassay systems. J Clin Chem Clin Biochem 17:111
38. Fischer JA, Binswager U, Dietrich FM 1974 Human parathyroid hormone: immunological characterization of antibodies against a glandular extract and the synthetic amino-terminus fragments 1-12 and 1-34 and their use in the determination of immunoreactive hormone in human sera. J Clin Invest 54:1382
39. Papapoulos SE, Manning RM, Hendy GN, Lewin IG, O'Riordan JLH 1980 Studies of circulating parathyroid hormone in man using a homologous amino-terminus specific immunoradiometric assay. Clin Endocrinol (Oxf) 13:57
40. Fischer JA, Oldham SB, Sizemore GW, Arnaud CD 1972 Calciumregulated parathyroid hormone peptidase. Proc Natl Acad Sci USA 69:2341
41. Morrissey JJ, Cohn DV 1979 Secretion and degradation of parathormone as a function of intracellular maturation of hormone pools: modulation by calcium and dibutyryl cyclic AMP. J Cell Biol 83:621
42. MacGregor RR, Hamilton JW, Cohn DV 1975 The by-pass of tissue hormone stores during the secretion of newly synthesized parathyroid hormone. Endocrinology 97:178
43. Hanley DA, Takatsuki KT, Sulton JM, Schneider AB, Sherwood LM 1978 Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro. J Clin Invest 62:1247
44. Mayer GP, Keaton JA, Hurst JG, Habener JF 1979 Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood. Endocrinology 104:1778
45. Dambacher MA, Fischer JA, Hunziker WH, Born W, Moran J, Roth H-R, Delvin EE, Glorieux FH 1979 Distribution of circulating immunoreactive components of parathyroid hormone in normal subjects and in patients with primary and secondary hyperparathyroidism: the role of the kidney and of the serum calcium concentration. Clin Sci 57:435
46. ++ concentrations. J Clin Invest 60:501
47. Canterbury JM, Bricker LA, Levey GS, Kozlovskis PL, Ruiz E, Zull JF, Reiss E 1975 Metabolism of bovine parathyroid hormone. Immunological and biological characteristics of fragments generated by liver perfusion. J Clin Invest 55:1245