Synthesis and Pharmacological Activity of 6-[(E)-2-(2,6,6-Trimethyl-l-cyclohexen-l-yl)ethen-l-yl]-and 6-(l,2,3,4-Tetrahydro-l,l,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic Acids

Journal of Medicinal Chemistry

Volumn 26, Issue 11, 1983, Pages 1653-1656

  Dawson, Marcia I ^a   Chan, Rebecca L S ^a   Derdzinski, Krzysztof ^a   Hobbs, Peter D ^a   Chao, Wan Ru ^a   Schiff, Leonard J ^b  

^a SRI INTERNATIONAL   (United States)

^b IIT RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (1,2,3,4 TETRAHYDRO 1,1,4,4 TETRAMETHYL 6 NAPHTHYL) 2 NAPHTHOIC ACID; 6 [2 (2,6,6 TRIMETHYL 1 CYCLOHEXEN 1 YL)VINYL] 2 NAPHTHOIC ACID; AROTINOID; NEW DRUG; ORNITHINE DECARBOXYLASE; PHORBOL 13 ACETATE 12 MYRISTATE; RETINOIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DOSE RESPONSE; DRUG ANALYSIS; DRUG ANTAGONISM; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROMETRY; KERATINIZATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RESPIRATORY SYSTEM; TRACHEA;

ANIMALS; BIOLOGICAL ASSAY; CRICETINAE; ENZYME INDUCTION; INDICATORS AND REAGENTS; KERATINS; MICE; NAPHTHALENES; ORGAN CULTURE TECHNIQUES; ORNITHINE DECARBOXYLASE; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP; TETRADECANOYLPHORBOL ACETATE; TRACHEA;

EID: 0021086286     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00365a021     Document Type: Article

References (18)

1. Sporn, M. B.; Newton, D. L.; Roberts, A. B.; DeLarco, J. E.; Todaro, G. J. In “Molecular Actions and Targets for Cancer Chemotherapeutic Agents”; Sartorelli, A. C.; Bertino, J. R.; Lazo, J. S., Eds.; Academic Press: New York, 1980.
2. Bollag, W.; Matter, A. Ann. N.Y. Acad. Sci. 1981, 359, 9.
3. Pawson, B. A.; Ehmann, C. W.; Itri, L. M.; Sherman, M. I. J. Med. Chem. 1982, 25, 1269.
4. Dawson, M. I.; Hobbs, P. D.; Kuhlmann, K.; Fung, V. A.; Helmes, C. T.; Chao, W.-R. J. Med. Chem. 1980,23,1013.
5. Dawson, M. I.; Hobbs, P. D.; Chan, R. L.; Chao, W.-R.; Fung, V. A. J. Med. Chem. 1981, 24, 583.
6. Dawson, M. I.; Hobbs, P. D.; Chan, R. L.; Chao, W.-R. J. Med. Chem. 1981, 24, 1214.
7. Newton, D. L.; Henderson, W. R.; Sporn, M. B. “Structure Activity Relationships of Retinoids. Tracheal Organ Culture Assay of Activity of Retinoids”; Laboratory of Chemoprevention, Division of Cancer Cause and Prevention, National Cancer Institute: Bethesda, MD, 1978.
8. Newton, D. L.; Henderson, W. R.; Sporn, M. B. Cancer Res. 1980, 40, 3413.
9. Acton, N.; Brossi, A.; Newton, D. L.; Sporn, M. B. J. Med. Chem. 1980, 23, 805.
10. Loeliger, P.; Bollag, W.; Mayer, H. Eur. J. Med. Chem. 1980, 25,9.
11. Chan, K. K.; Specian, A. C., Jr.; Pawson, B. A. J. Med. Chem. 1981, 24,101.
12. Lovey, A. J.; Pawson, B. A. J. Med. Chem. 1982, 25, 71.
13. Raineri, R.; Simsiman, R. C.; Boutwell, R. K. Cancer Res. 1973, 33,134.
14. Verma, A. K.; Lowe, N.; Boutwell, R. K. Cancer Res. 1979, 39, 1035.
15. Wood, T. F.; Evans, W. F. (Givaudan Corp.). U.S. Patent 3499 751, 1970
16. Chem. Abstr. 1970, 72, 132389e.
17. Anderson, L. C.; Johnston, D. J. Am. Chem. Soc. 1943, 65, 239.
18. Negishi, E.; King, A. O.; Okukado, N. J. Org. Chem. 1977, 42, 1823.