Kinetics of sodium channel modification as the basis for the variation in the nerve membrane effects of pyrethroids and DDT analogs

Pesticide Biochemistry and Physiology

Volumn 20, Issue 2, 1983, Pages 203-216

  Lund, Albert E ^a   Narahashi, Toshio ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPHENOTANE; INSECTICIDE; PYRETHROID; TETRODOTOXIN;

ANIMAL CELL; CHLORPHENOTANE ANALOG; CRAYFISH; DRUG EFFICACY; GIANT AXON; INTOXICATION; INVERTEBRATE; NERVE CELL MEMBRANE POTENTIAL; NERVE FIBER MEMBRANE POTENTIAL; NERVOUS SYSTEM; NEUROTOXICITY; NONHUMAN; SODIUM CHANNEL; STRUCTURE ACTIVITY RELATION;

EID: 0021052526     PISSN: 00483575     EISSN: 10959939     Source Type: Journal    
DOI: 10.1016/0048-3575(83)90025-1     Document Type: Article

References (35)

1. The action of pyrethroids in the insect nervous system I Features of molecular structure associated with toxicity to cockroaches and to their giant fibre axons
2. Insecticide screening with isolated nerve preparations for structure-activity relationships
3. Structure-activity relationships of pyrethroids based on direct action on the nerve
4. The actions of pyrethroids upon the peripheral nervous system and associated organs in the locust
5. Quantitative structure-activity studies of substituted benzyl chrysanthemates. 1. Correlations between symptomatic and neurophysiological activities against American cockroaches
6. Quantitative structure-activity studies of substituted benzyl chrysanthemates. 2. Physicochemical substitutent effects and neurophysiological and symptomatic activities against American cockroaches
7. Quantitative structure-activity studies of substituted benzyl chrysanthemates. 3. Physiocochemical substituent effects and the spontaneous neuroexcitatory activity on the crayfish abdominal nerve cords
8. Frequency-dependent effects of the pyrethroid insecticide decamethrin in frog myelinated nerve fibres
9. Two classes of pyrethroid action in the cockroach
10. Site and types of action of pyrethroids on nerve membrane
11. A method of physiological assay of pyrethrum extract
12. Effect of the insecticide allethrin on membrane potentials of cockroach giant axons
13. The mode of action of certain insecticides on the arthropod nerve axon
14. Studies on the mechanism of action of insecticides (IV). The effects of insecticides on the nerve conduction of insect
15. Mechanism of excitation block by the insecticide allethrin applied externally and internally to squid giant axons
16. Mechanism of negative temperature coefficient of nerve blocking action of allethrin
17. Modification of sodium channel kinetics by the insecticide tetramethrin in crayfish giant axons
18. Kinetics of sodium channel modification by the insecticide tetramethrin in squid axon membranes
19. Effects of allethrin and Condylactis toxin on the kinetics of sodium conductance of crayfish axon membranes
20. Similar mode of action of pyrethroids and DDT on sodium channel gating in myelinated nerves
21. A physiological solution for freshwater crustaceans
22. Membrane potentials of the lobster giant axon obtained by use of the sucrose-gap technique
23. Current-voltage relations in the lobster giant axon membrane under voltage clamp conditions
24. Pharmacological modifications of the sodium channels of frog nerve
25. DDT: Interaction with nerve membrane conductance changes
26. Interaction of DDT with the components of lobster nerve membrane conductance
27. Interaction of DDT with sodium channels in squid giant axon membranes
28. Interaction of a DDT analog with the sodium channel of lobster axon
29. Pharmacokinetic behavior of enantiomeric pyrethroid esters in the cockroach, Periplaneta americana L
30. A quantitative description of membrane current and its application to conduction and excitation in nerve
31. DDT and related substances: Effects on permeability properties of myelinated Xenopus nerve fibre. Potential clamp analysis
32. Asymmetrical currents and sodium currents in Ranvier nodes exposed to DDT
33. Preferred conformations of pyrethroids
34. Action of pyrethroids
35. Dose-dependent interaction of the pyrethroid isomers with sodium channels of squid axon membranes