6α-hydroxy-iso-ML-236B (6α-hydroxy-iso-compactin) and ML-236A, microbial transformation products of ML-236B

Journal of Antibiotics

Volumn 36, Issue 7, 1983, Pages 918-920

  Serizawa, Nobufusa ^a   Nakagawa, Keiko ^a   Tsujita, Yoshio ^a   Terahara, Akira ^a   Kuwano, Harumitsu ^a   Tanaka, Minoru ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6ALPHA HYDROXYISOCOMPACTIN; COMPACTIN; ISOCOMPACTIN; ML 236A; UNCLASSIFIED DRUG;

ABSIDIA COERULEA; ARTICLE; DRUG ANALYSIS; DRUG IDENTIFICATION; DRUG METABOLISM; FUNGUS; IN VITRO STUDY; MASS SPECTROMETRY; MUCOR HIEMALIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRELIMINARY COMMUNICATION; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY;

BIOTRANSFORMATION; FUNGI; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MAGNETIC RESONANCE SPECTROSCOPY; MUCORALES; NAPHTHALENES; NAPHTHOLS; SPECIES SPECIFICITY;

EID: 0021031624     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.36.918     Document Type: Article

References (5)

1. Endo, A.; M. Kuroda & Y. Tsujita: Ml- 236a, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiotics 29: 1346 — 1348, 1976
2. Endo, A.; M. Kuroda & K. Tanzawa: Competitive inhibition of 3-hydroxy-3-methylglutaryl Coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Letters 72: 323 — 326, 1976
3. Brown, A. G.; T. C. Smale, T. J. King, R. Hasenkamp& R. H. Thompson: Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum. J. Chem. Soc., Perkin I 1976: 1165 — 1170, 1976
4. Serizawa, N.; K. Nakagawa, Y. Tsujita, A. Terahara & H. Kuwano: 3a-hydroxy-ml-236b (3a-hydroxycompactin), microbial transformation product of ML-236B (compactin). J. Antibiotics 36: 608–610, 1983
5. Serizawa, N.; K. Nakagawa, K. Hamano, Y. Tsujita, A. Terahara& H. Kuwano: Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B). J. Antibiotics 36: 604–607, 1983