Oxytocin is a precursor of potent behaviourally active neuropeptides

European Journal of Pharmacology

Volumn 94, Issue 1-2, 1983, Pages 125-131

  Burbach, J Peter H ^a   Bohus, Béla ^a   Kovács, Gabor L ^b   Van Nispen, Jan W ^b   Greven, Henk M ^b   de Wied, David ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NV ORGANON   (Netherlands)

Author keywords

Behaviour; Memory consolidation; Neuropeptides; Oxytocin; Oxytocin fragment; Peptidase

Indexed keywords

HEXAPEPTIDE; NEUROPEPTIDE; OXYTOCIN; OXYTOCIN DERIVATIVE;

ANIMAL CELL; AVOIDANCE BEHAVIOR; BEHAVIOR; CENTRAL NERVOUS SYSTEM; FOREBRAIN; MEMORY; MEMORY CONSOLIDATION; NERVOUS SYSTEM; NONHUMAN; RAT; SYNAPTOSOME;

ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; FEMALE; INJECTIONS, INTRAVENTRICULAR; MALE; MEMBRANES; NERVE TISSUE PROTEINS; OXYTOCIN; PROTEIN PRECURSORS; RATS; UTERINE CONTRACTION;

EID: 0021013237     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(83)90449-1     Document Type: Article

References (41)

1. Effects of lysine-vasopressin on passive avoidance learning
2. Oxytocin, vasopressin and memory: opposite effects on consolidation and retrieval processes
3. Opposite effects of oxytocin and vasopressin on avoidance behavior and hippocampal theta rhythm in the rat
4. Oxytocin biotransformation in the rat limbic brain: Characterization of peptidase activities and significance in the formation of oxytocin fragments
5. Proteolytic conversion of β-endorphin by brain synaptic membranes
6. Memory effects and brain proteolysis of neurohypophyseal hormones
7. A major metabolite of arginine-vasopressin in brain is a highly potent neuropeptide
8. Proteolytic conversion of arginine-vasopressin and oxytocin by brain synaptic membranes: characterization of formed peptides and mechanism of proteolysis
9. Sensitive and rapid amino acid analysis of peptide hydrolysates by high-pressure liquid chromatography of o-phthaldialdehyde-derivatives
10. Oxytocin biotransformation in the rat limbic brain: chemical characterization of two oxytocin fragments and proposed pathway for oxytocin conversion
11. Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat pathways to the limbic system medulla oblongata and spinal cord
12. Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone
13. Peptides and behavior
14. Behavioural actions of neurohypophyseal peptides
15. The modulation of memory processes by vasotocin, the evolutionary oldest neurosecretory principle
16. Pyrrolidonyl peptidase, an enzyme for selective removal of pyrrolidonecarboxylic acid residues from polypeptides
17. Active polypeptides: from amphibian skin to gastrointestinal tract and brain of mammals
18. Influence of oxytocin on human memory processes
19. Synthesis and relationship of L-glutaminyl-L-histidyl-L-prolinamide to the thyrotropin releasing hormone
20. Rapid sequence analysis of small peptides
21. Amino acid analysis and enzymatic sequence determination of peptides by an improved o-phthaldialdehyde precolumn labeling procedures
22. 19
23. Influence of oxytocin on human memory processes: validation by a control study
24. High performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with o-phthaldialdehyde
25. 2 (PLG or MIF-I): evidence that PLG is not present in rat brain
26. Active peptides in amphibian skin
27. Magnocellular hypothalamic projections to the lower brain stem and spinal cord of the rat
28. Inhibition of the action of oxytocin on the rat uterus by acylic oxytocin intermediates
29. Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin
30. The neurosecretory neuron: a model system for the study of secretion
31. A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate aminopeptidase
32. Biosynthesis of vasopressin, oxytocin, and neurophysins: isolation and characterization of two common precursors (propressophysin and prooxyphysin)
33. Neurosecretion
34. Isolation and amino acid sequence of a morphogenetic peptide from hydra
35. The failure of L-prolyl-L-leucyl-glycinamide to inhibit the release of α-melanocyte-stimulating hormone in the rat
36. Neurohypophyseal principles and memory processes
37. Oxytocin and other hormones at prohormones
38. Production of MSH-release-inhibiting hormone by a particulate preparation of hypothalami: mechanism of oxytocin inactivation
39. Neurohypophyseal hormones, analogs, and fragments: their effect on puromycin-induced amnesia
40. Immunochemical localization of hypothalamic peptide hormones in neural target areas
41. 2: metabolism in human and rat plasma investigated by high-pressure liquid chromatography