A model for the resistance of tumor cells to cancer chemotherapeutic agents

Mathematical Biosciences

Volumn 65, Issue 2, 1983, Pages 291-307

  Coldman, A J ^a   Goldie, J H ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS - EVALUATION; MATHEMATICAL MODELS - MEDICAL APPLICATIONS; OPTIMIZATION; PROBABILITY - RANDOM PROCESSES;

CHEMOTHERAPEUTIC AGENTS; TUMOR CELL RESISTANCE;

BIOMEDICAL ENGINEERING;

ANTINEOPLASTIC AGENT;

DRUG MIXTURE; DRUG RESISTANCE; HUMAN; MATHEMATICAL MODEL; NONBIOLOGICAL MODEL; THERAPY;

EID: 0020805347     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/0025-5564(83)90066-4     Document Type: Article

References (9)

1. Mutations of Bacteria from Virus Sensitivity to Virus Resistance.
2. The distribution of the numbers of mutants in bacterial populations
3. The statistical theory of bacterial populations subject to mutation
4. Mathematical models for estimating mutation rates in cell populations
5. Dose-response and tumor cell repopulation rate in chemotherapeutic trials
6. Origin of the resistance of leukaemic cells to folic acid antagonists
7. A mathematical model relating the drug sensitivity of tumors to their spontaneous mutation rate
8. A rationale for the use of alternating non-cross resistant chemotherapy