Interaction of the antileukemic alkaloid, 2-hydroxy-3,8,9-trimethoxy-5-methylbenzo[c]phenanthridine (fagaronine), with nucleic acids

Chemico-Biological Interactions

Volumn 43, Issue 3, 1983, Pages 323-339

  Pezzuto, John M ^a   Antosiak, Sharon K ^a   Messmer, Wilhelmina M ^a   Slaytor, Michael B ^a   Honig, George R ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

Activity modulation with rat liver preparation; Bactericidal, cytotoxic and mutagenic potential; Isolation; Mechanism of action; Quantitative interaction with DNA; Structure function relationships

Indexed keywords

2 HYDROXY 3,8,9 TRIMETHOXY 5 METHYLBENZO[C]PHENANTHRIDINE; 3 METHYLCHOLANTHRENE; ANTILEUKEMIC AGENT; DNA; FAGARONINE; NORFAGARONINE; NUCLEIC ACID; PHENOBARBITAL; POLYCHLORINATED BIPHENYL; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL CELL; ARTICLE; CHEMICAL MUTAGENESIS; DOSE RESPONSE; DRUG BINDING; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; DRUG RESISTANCE; DRUG RESPONSE; HEREDITY; IN VITRO STUDY; INTOXICATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CHEMISTRY; DNA; ESCHERICHIA COLI; MUTAGENICITY TESTS; MUTAGENS; MUTATION; PHENANTHRIDINES; POLYDEOXYRIBONUCLEOTIDES; POLYRIBONUCLEOTIDES; RNA, TRANSFER; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP; THYMUS GLAND;

ANIMALIA; FAGARA; FAGARA ZANTHOXYLOIDES; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0020698654     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(83)90116-3     Document Type: Article

References (36)

1. The mechanism of action of fagaronine, a novel tumor inhibitor
2. A review of selected potential anticancer plant principles
3. A review of the chemistry of the antitumor benzo[c]phenanthridine alkaloids nitidine and fagaronine and of related antitumor alkaloid coralyne
4. Benzophenanthridinium salt equilibria
5. Fluorescence spectra and cation-pseudobase equilibria of some benzophenanthridine alkaloids
6. Chemistry of benzo[c]phenanthridine alkaloids having antineoplastic activity
7. Isolation and characterization of an antisickling agent from Fagara zanthoxyloides root
8. Chromatographic fractionation of antisickling agents in Fagara xanthoxyloides
9. Evaluation of Fagara zanthoxyloides root extract in sickle cell anemia blood in vitro
10. Fagaronine, a new tumor inhibitor isolated from Fagara zanthoxyloides Lam. (Rutaceae)
11. Synthesis and biological activity of some antitumor benzophenanthridinium salts
12. Inhibition of reverse transcriptase activity of RNA-tumor viruses by fagaronine
13. Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids
14. Base specificity in the inhibition of oncornavirus reverse transcriptase and cellular nucleic acid polymerases by antitumor drugs
15. Inhibition of reverse transcriptase activity by benzophenanthridine alkaloids
16. Potential anticancer agents. I. Confirming evidence for the structure of fagaronine
17. Protein measurement with the Folin phenol reagent
18. Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium
19. Metabolic activation of 1-methyl-3-amino-5-H-pyrido[4,3-b]indole and several structurally related mutagens
20. Cell culture screen, KB
21. Measurement of cell growth in tissue culture with a phenol reagent (Folin-Ciocalteau)
22. The attraction of proteins for small molecules and ions
23. Interactions of methylated acridines with DNA
24. The unwinding of circular deoxyribonucleic acid by phenanthridinium drugs: structure-activity relationships for the intercalation reaction
25. Steric effects on the interaction of aromatic cation to deoxyribonucleic acid
26. Miracil D: effect on the viscosity of DNA
27. Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies
28. There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5-H-pyrido[4,3-b]indoles
29. The interaction of intercalating drugs with nucleic acids
30. Absence of mutagenicity of coralyne and related antileukemic agents: structural comparison with the potent carcinogen 7,12-dimethylbenz[a]anthracene
31. Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens
32. Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens
33. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals
34. Short-term tests for carcinogens and mutagens
35. Mechanisms of chemical carcinogenesis
36. Chemical carcinogenesis