Effects of azathioprine on the human mixed lymphocyte reaction (MLR).

British Journal of Clinical Pharmacology

Volumn 15, Issue 2, 1983, Pages 203-209

  Al‐Safi, SA ^a   Maddocks, JL ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; DITHIOTHREITOL; GLUTATHIONE; MERCAPTOPURINE; RADIOISOTOPE;

BLOOD AND HEMOPOIETIC SYSTEM; CELL DIVISION; CYTOLOGY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG COMPARISON; DRUG DOSE; DRUG MECHANISM; DRUG RESPONSE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHATIC SYSTEM; MIXED LYMPHOCYTE REACTION; NORMAL HUMAN; PHARMACOKINETICS; THYMIDINE H 3;

6-MERCAPTOPURINE; AZATHIOPRINE; DITHIOTHREITOL; DNA; ERYTHROCYTES; GLUTATHIONE; HUMAN; LYMPHOCYTE CULTURE TEST, MIXED; NITROIMIDAZOLES; THYMIDINE;

EID: 0020694912     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1983.tb01487.x     Document Type: Article

References (25)

1. The mechanism of action of azathioprine on the mixed lymphocyte reaction (MLR)
2. Activities of immunosuppressive agents in vitro. II. Different timing of azathioprine and methotrexate in inhibition and stimulation of mixed lymphocyte reaction
3. Activities of immunosuppressive agents in vitro. I. Rosette inhibition by azathioprine
4. In vitro evaluation of immunosuppressive drugs
5. One‐way stimulation in mixed leukocyte cultures
6. Separation of leukocytes from human blood
7. Isolation of lymphocytes, granulocytes and macrophages
8. Inhibition of the rejection of renal homografts in dogs by purine analogues
9. Studies on the mechanism of formation of 5‐mercapto‐l‐methyl‐4‐nitroimidazole. A metabolite of the immunosuppressive drug azathioprine
10. Conversion of azathioprine into mercaptopurine and mercaptoimidazole derivatives in vitro and during immunosuppressive therapy
11. Immunosuppression by 9‐alkyl‐6‐thiopurines
12. Biochemistry and pharmacology of purine analogues
13. A summary of investigations with 6‐[(l‐methyl‐4‐nitro‐5‐imidazolyl)thiol] purine (B.W. 57–322)
14. The effect of thiol compounds on lymphocytes stimulated in culture
15. Progress in immunosuppression
16. Differential inhibition by azathioprine and 6‐mercaptopurine of specific suppressor T cell generation in mice
17. Alteration of lymphocyte response by sulfhydryl and disulfide compounds
18. The metabolic fate of the methyl‐nitroimidazole moiety of azathioprine in the rat
19. The action of cytseine on PHA‐stimulation of lymphocytes. I. Influence on DNA synthesis
20. Effect of D‐penicillamine on lymphocyte function
21. Depression of lymphocyte transformation by drugs in vitro. Effects of a new immunosuppressant, cinanserin
22. Immunosuppressive drugs in lymphocyte mixed cultures
23. Inhibition of protein synthesis in human lymphocytes by thiopurines
24. The effect of prednisolone and azathioprine in mixed leukocyte cultures
25. Cessation of immunosuppressive therapy after successful transplantation: A national survey