Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

Journal of Neurochemistry

Volumn 40, Issue 3, 1983, Pages 842-849

  Wilk, Sherwin ^a   Orlowski, Marian ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Chymotrypsin like activity; Enkephalins; Enzyme complex; Neutral endopeptidase; Pituitary; Trypsin like activity

Indexed keywords

ENKEPHALIN; ENZYME; LEUPEPTIN; PROTEINASE;

ANIMAL CELL; CATTLE; ENDOCRINE SYSTEM; HYPOPHYSIS; NONHUMAN;

ANIMAL; CATTLE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; LEUPEPTINS; MULTIENZYME COMPLEXES; NEPRILYSIN; OLIGOPEPTIDES; PITUITARY GLAND; POTASSIUM CHLORIDE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0020674228     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1983.tb08056.x     Document Type: Article

References (17)

1. The use of esters of N‐hydroxysuccinimide in peptide synthesis
2. The determination of enzyme inhibitor constants
3. Phosphorylation of proteins with phosphoric acid containing excess phosphorous pentoxide
4. Synthese eines hepta‐peptides mit starker CRG‐wirkung
5. Thiohemiacetal formation by inhibitory aldehydes at the active site of papain
6. Generation of methionine and leucine‐enkephalin from precursor molecules by cation‐sensitive neutral endopeptidase of bovine pituitary
7. Purification and specificity of a membrane‐bound metalloendopeptidase from bovine pituitaries
8. A multicatalytical protease complex from pituitary that forms enkephalin and enkephalin containing peptides
9. Sulfoxide‐carbodiimide reactions. I. A facile oxidation of alcohols
10. Inhibition of brain glutamate decarboxylase by 2‐keto‐4‐pentenoic acid, a metabolite of allylglycine
11. 2‐macroglobulin subunits
12. Use of peptide aldehydes to generate transition‐state analogs of elastase
13. Peptide aldehydes: Potent inhibitors of serine and cysteine proteinases
14. Activities of proteinase in hibitors of microbial origin
15. The reliability of molecular weight determinations by dodecyl sulfate‐polyacrylamide gel electrophoresis
16. Cation‐sensitive neutral endo peptidase: Isolation and specificity of the bovine pituitary enzyme
17. Identification and partial purification of a cation‐sensitive neutral endopeptidase from bovine pituitaries