Genotoxicity of tobacco smoke and tobacco smoke condensate

Mutation Research/Reviews in Genetic Toxicology

Volumn 114, Issue 1, 1983, Pages 59-89

  DeMarini, David M ^a  

^a University of Tennessee Oak Ridge Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; 9 HYDROXYELLIPTICINE; AROCLOR 1254; ARSENIC; INDOLE DERIVATIVE; PHENOBARBITAL; POLYCHLORINATED BIPHENYL; TOBACCO; TOBACCO SMOKE;

ARTHROPOD; CHEMICAL MUTAGENESIS; CHROMOSOME ABERRATION; DROSOPHILA; HEREDITY; IN VITRO STUDY; MUTAGENICITY; NEUROSPORA; NONHUMAN; REVIEW; SISTER CHROMATID EXCHANGE;

ANIMAL; CELL LINE; DNA REPAIR; HUMAN; LUNG NEOPLASMS; MALE; MUTAGENICITY TESTS; MUTAGENS; MUTATION; NEUROSPORA CRASSA; PLANTS, TOXIC; SACCHAROMYCES CEREVISIAE; SALMONELLA TYPHIMURIUM; SMOKING; SPERMATOZOA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TOBACCO;

EID: 0020656837     PISSN: 01651110     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1110(83)90019-2     Document Type: Article

References (160)

1. Genetics of aryl hydrocarbon hydroxylase induction in mice: Response of the lung to cigarette smoke and 3-methylcholanthrene
2. Non-mutagenicity of urine from coffee drinkers compared with that from cigarette smokers
3. Maternal factors associated with fetal chromosomal anomalies in spontaneous abortions
4. A study of smoking in pregnancy
5. Sister-chromatid exchanges in cigarette-smoking human females and their newborns
6. Aryl hydrocarbon hydroxylases in normal and cancer populations
7. Effect of moderate carbon-monoxide exposure on fetal development
8. Genetic control of inter-individual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes
9. A comparison of short term bioassay results with carcinogenicity of experimental cigarettes
10. Malignant transformation of mouse cells by cigarette smoke condensate
11. Activation of 2-aminoanthracene to mutagenic intermediates by guinea pig kidney microsomal enzymes following tobacco smoke inhalation
12. Bioassay of major fractions of cigarette smoke condensate by an accelerated technic
13. Composition studies on tobacco, XLIV. Tumor-promoting activity of subfractions of the weak acid fraction of cigarette smoke condensate
14. Cigarette smoking — Does it carry a genetic risk?
15. Factors affecting the levels of nitrate nitrogen in cured tobacco leaves
16. Mutagenic activity of marijuana smoke condensates
17. Smoking in pregnancy and subsequent child development
18. Sister chromatid exchange frequencies in humans: The effect of smoking
19. On neural-tube defects: An epidemiological elicitation of etiological factors
20. Gross differences observed in the placentas of smokers and nonsmokers
21. +/− mouse lymphoma mutagen assay system
22. Smoking during pregnancy and its effects on the fetus
23. Sister chromatid exchange in cigarette smokers
24. Chronic inhalation of cigarette smoke by F344 rats
25. Ultrastructural studies on cells of hamster lung cultures after chronic exposure to whole smoke or the gas vapour phase of cigarettes
26. Mutagenicity of fractions of cigarette smoke condensate in Neurospora crassa and Salmonella typhimurium
27. Mutagenicity of cigarette smoke condensate in Neurospora crassa
28. Comparison of the induction by cigarette smoke condensates of sister-chromatid exchanges in Chinese hamster cells and of mutations in Salmonella typhimurium
29. Exposure to carcinogenic chemicals and smoking increases urinary excretion of mutagens in humans
30. Introduction
31. The causes of cancer: Quantitative estimates of the avoidable risks of cancer in the United States today
32. Sperm abnormalities and cigarette smoking
33. Maternal smoking habits and congenital malformations: A population study
34. Individuals transplacentally exposed to maternal smoking may be at increased cancer risk in adult life
35. Screening of tobacco smoke constituents for mutagenicity using the Ames' test
36. Activation and isolation of hamster-specific C-type RNA viruses from tumors induced by cell cultures transformed by chemical carcinogens
37. Genetic effects of fresh cigarette smoke in Saccharomyces cerevisiae
38. Time trends in lung cancer mortality among nonsmokers and a note on passive smoking
39. Inhibition of DNA repair by cocarcinogens
40. Mutagenic urine in cirrhosis
41. Sperm morphology in smokers
42. Bioassay procedure for the detection of mutagenic metabolites in human urine with the use of sister chromatid exchange analysis
43. Factors influencing the measurement and reproducibility of aryl hydrocarbon hydroxylase activity in cultured human lymphocytes
44. Induction and potentiation of lethal and genetic effects of ultraviolet light by tobacco smoke condensates in yeast
45. Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus
46. Cigarette smoking during pregnancy and the occurrence of spontaneous abortion and congenital abnormality
47. Non-smoking wives of heavy smokers have a higher risk of lung cancer: A study from Japan
48. On the identification of carcinogens, tumor promoters and cocarcinogens in tobacco smoke
49. Tobacco carcinogenesis
50. Chemical composition and tumorigenicity of tobacco smoke
51. Environmental respiratory carcinogenesis
52. Sister chromatid exchanges in the peripheral blood of cigarette smokers and in lung cancer patients; and the effect of chemotherapy
53. The consequences of smoking in pregnancy
54. Cigarette smoke condensates damage DNA in human lymphocytes
55. Cigarette smoke-induced DNA damage and lung cancer risks
56. Benzo(a)pyrene does not contribute to the SCEs induced by cigarette smoke condensate
57. Induction and transmission of elevated levels of abnormally shaped murine sperm
58. Smoking and sister chromatid exchange
59. Metabolism of cigarette smoke condensates by human and rat homogenates to form mutagens detectable by Salmonella typhimurium TA1538
60. Effect of cigarette tar upon tissue culture cells
61. Acceleration of proliferation and tumor production rate of L-strain cells by treatment with cigarette tar
62. Effects genétiques de la phase gazeuse de la fumée de cigarette sur Saccharomyces cerevisiae
63. Influence des paramètres de fumage sur l'activité génotoxique de la phase gazeuse de fumée de cigarette, mesurée sur le lymphocyte humain et la levure
64. Sur l'activité chromatoclassique et mitoclasique de certaines fractions de goudrons de fumée de cigarette
65. Biotransformation and bioactivation of 7,12-dimethylbenz[α]anthracene in human fetal and placental tissues
66. Variation of microsomal mixed function oxidase(s) and human lung cancer
67. Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes
68. Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma
69. Maternal smoking and congenital malformations: An epidemiological study
70. Animal models for the study of tobacco carcinogenesis
71. Detection of mutagenic activity in cigarette smoke condensates
72. Smoking: A risk factor for spontaneous abortion
73. Simultaneous exposure of Chinese hamsters to ethanol and cigarette smoke: Cytogenetic aspects
74. Biological activity of tobacco smoke and tobacco smoke-related chemicals
75. Increased frequency of sister chromatid exchanges in cigarette smokers
76. Smoking during pregnancy
77. Observations on the effects of condensates from cigarette smoke on human foetal lung in vitro
78. The effect of a hydrocarbon-enriched fraction of cigarette smoke condensate on human fetal lung grown in vitro
79. Mutagenicity of aminocarbazoles and nitrocarbazoles
80. The less harmful cigarette and tobacco smoke flavors
81. Ellipticines as potent inhibitors of drug metabolism: Protective effect against chemical mutagenesis and carcinogenesis
82. Differential cytological and cytochemical responses of various cultures from mouse tissues to repeated exposures to puffs from the gas phase of charcoal-filtered fresh cigarette smoke
83. Morphological and cytochemical effects of marijuana cigarette smoke on epithelioid cells of lung explants from mice
84. Effects of marijuana and tobacco smoke on human lung physiology
85. Significance of oxides of nitrogen (NO) and SA reactive components in pulmonary carcinogenesis
86. N-Nitroso compounds and related carcingens
87. Mutagenic activity of amino acid pyrolyzates in Salmonella typhimurium TA98
88. Determination of mutagens, amino-α-carbolines in grilled foods and cigarette smoke condensate
89. Die Auswirkungen des vaterlichen Zigarettenkonsums auf die perinatale Sterblichkeit und die Missbildungshäufigkeit
90. Relation between chemical constitutents of tobacco and mutagenic activity of cigarette smoke condensate
91. Factors affecting mutagenic activity of cigarette smoke condensate in Salmonella typhimurium TA1538
92. Frequency of sister chromatid exchanges in cigarette smokers
93. Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women
94. Tumors and hyperplastic lesions in Syrian hamsters following transplacental and neonatal treatment with cigarette smoke condensate
95. Occupational and environmental risks in and around a smelter in northern Sweden, II. Chromosomal aberrations in workers exposed to arsenic
96. Chromosomal aberrations in heavy smokers
97. Genetics of aryl hydrocarbon hydroxylase in the human population and its relationship to cancer
98. Seasonal variation of aryl hydrocarbon hydroxylase activity in human lymphocytes
99. Cytogenetic effects of the gaseous phase of cigarette smoke on root-tip cells of Allium sativum L
100. Mutagenicity of cigarette smoke condensate and cigarette smoke in Drosophila melanogaster
101. Smoking during pregnancy
102. Analysis of mutagenic activity in cigarette smokers' urine by high performance liquid chromatography
103. Application of mutagenicity testing to urine samples obtained from animals exposed to cigarette smoking
104. DNA replication and unscheduled DNA synthesis in lungs of mice exposed to cigarette smoke
105. Chromosomal aberrations and neoplasms — slight effect of two smoke fractions
106. International Cancer Congress
107. Effect of cigarette smoking on susceptibility to lung cancer
108. In vitro transformation assay of major fractions of cigarette smoke condensate (CSC) in mammalian cell lines (37162)
109. Potentiating effect of cigarette smoke extract on morphological transformation of hamster embryo cells by benzo[a]pyrene
110. Synergistic effects of cigarette smoke extracts, benz[a]pyrene and nickel sulphate on morphological transformation of hamster embryo cells
111. Induction of transformation by tobacco smoke condensate using host-mediated system
112. Cytological studies on onion root-tip cells treated with water-soluble extract of tobacco smoke condensate from commercial cigarettes
113. Reduction in mutagenicity of cigarette smoke condensate by added sugars
114. Mutagenicity of smoke condensates from cigarettes, cigars and pipe tobacco
115. Teratology studies on inhaled carbon monoxide and imbibed ethanol in laboratory animals
116. Metabolism of carcinogens and tobacco smoke fraction by adult and fetal rat liver homogenates to form mutagens detectable by Salmonella test system
117. Responses of exercising subjects to acute ‘passive’ cigarette smoke exposure
118. Factors associated with the occurrence of early resorption of human embryos
119. Stimulatory effect of cigarette smoke on the metabolism and covalent binding of benzo[a]pyrene in the trachea of the rat
120. Presenza di sostanze mutagene nelle urine di fumatori
121. Experimental induction of epidermoid carcinoma in the lungs of rats by cigarette smoke condensate
122. Mutagen-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled foods
123. Large-scale fractionation of cigarette smoke condensate for chemical and biologic investigations
124. In vitro morphological transformation of cryopreserved hamster embryo cells with tobacco tar
125. Prenatal exposure to chemical carcinogens and its effect on subsequent generations
126. Lung cancer and passive smoking
127. In vitro transformation of hamster embryo cells by betel tobacco extracts
128. Parental smoking empirically related to pregnancy outcome
129. Action de la phase gazeuse de fumée de cigarette sur le taux d'échanges des chromatides-soeurs du lymphocyte humain in vitro
130. Thioether concentration and mutagenicity of urine from cigarette smokers
131. Effects of smoking on benzo[a]pyrene metabolism by human placental microsomes
132. The influence of substances extracted from cigarette-smoke on mitotic processes in Allium cepa
133. Ergebnisse von Spermauntersuchungen bei Zigarettenrauchern
134. Mutagenicity of marijuana and Transkei tobacco smoke condensates in the Salmonella/microsome assay
135. Cigarette smoking: Stimulatory effect on metabolism of 3,4-benzypyrene by enzymes in human placenta
136. Stimulatory effect of cigarette smoking on the hydroxylation of 3,4-benzpyrene and the N-demethylation of 3-methyl-4-monomethylaminoazobenzene by enzymes in human placenta
137. Smoking and Its Effect on Health
138. Tobacco and tobacco smoke
139. A study of tobacco carcinogenesis, X. Tumor promoting activity
140. Tobacco and health: A societal challenge
141. Chemical induction of sperm abnormalities in mice
142. Concentration of mutagens from urine by adsorption with the nonpolar resin XAD-2: Cigarette smokers have mutagenic urine
143. Changes in mutagenicity of protein pyrolyzates by reaction with nitrite
144. Amino-α-carbolines as mutagenic agents in cigarette smoke condensate
145. SCEs in lymphocytes of rats after exposure in vivo to cigarette smoke or to cyclophosphamide
146. The identification and characterization of a urinary mutagen resulting from cigarette smoke
147. Bacterial mutagenicity testing: Some practical considerations
148. Mutagenicity in urine of workers in rubber industry
149. Co-mutagenic effects of 2-aminoanthracene and cigarette smoke condensate on smoker's urine in the Ames Salmonella system
150. Mutagenicity of cigarette smoke in Drosophila melanogaster
151. Cytogenetic effects of cigarette smoke condensates in vitro and in vivo
152. Comparative studies on spontaneous and mitomycin-C-induced sister-chromatid exchanges in smokers and non-smokers
153. Chromosomal aberrations in peripheral lymphocytes of alcoholics
154. Double-blind study on the effect of cigarette smoking on the chromosomes of human peripheral blood lymphocytes in vivo
155. Induction of sister-chromatid exchange in human lymphocytes by smoke condensates from different brands of cigarette
156. In vivo and in vitro effects of cigarette smoke on chromosomal damage and sister-chromatid exchange in human peripheral blood lymphocytes