Induction of murine autoimmune disease by chronic polyclonal B cell activation

Journal of Experimental Medicine

Volumn 157, Issue 3, 1983, Pages 874-883

  Hang, Leming ^a   Slack, John H ^a   Amundson, Cathy ^a   Izui, Shozo ^a   Theofilopoulos, Argyrios N ^a   Dixon, Frank J ^a  

^a Scrzpps Clinic and Research Foundation ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA ANTIBODY; HEPARIN; LIPOPOLYSACCHARIDE; SALMONELLA MINNESOTA LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BLOOD AND HEMOPOIETIC SYSTEM; DRUG EFFICACY; LYMPHOCYTE TRANSFORMATION; MOUSE; NONHUMAN; RETICULOENDOTHELIAL SYSTEM;

ANIMALS; ANTIBODY-PRODUCING CELLS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; BLOOD COAGULATION; BLOOD UREA NITROGEN; CHRONIC DISEASE; FEMALE; GLOMERULONEPHRITIS; HEMOLYTIC PLAQUE TECHNIQUE; HEPARIN; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL;

EID: 0020639832     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.157.3.874     Document Type: Article

References (34)

1. Moutsopoulos, H. M., M. Boehm-Truitt, S. S. Kassan, and T. N. Chused. 1977. Demonstration of activation of B lymphocytes in New Zealand black mice at birth by an immunoradiometric assay. J. Immunol. 119:1639.
2. Theofilopoulos, A. N., and F. J. Dixon. 1981. Etiopathogenesis of murine SLE. Immunol. Rev. 55:179.
3. Coutinho, A., E. Gronowicz, W. W. Bullock, and G. Moller. 1975. Mechanism of thymus-independent immunocyte triggering. J. Exp. Med. 139:74.
4. Fournie, G. J., P. H. Lambert, and P. A. Miescher. 1974. Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysaccharides. J. Exp. Med. 140:1189.
5. Izui, S., P. H. Lambert, G. Fournie, H. Turler, and P. A. Miescher. 1977. Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides. Identification of circulating DNA and renal localization of DNA-anti-DNA complexes. J. Exp. Med. 145:1115.
6. Andersson, J., F. Melchers, G. Galanos, and O. Luderitz. 1973. The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule. J Exp. Med. 137:943.
7. Andersson, J., A. Coutinho, and F. Melchers. 1978. The switch from IgM to IgG secretion in single mitogen-stimulated B cell clones. J. Exp. Med. 147:1744.
8. Izui, S., R. A. Eisenberg, and F.J. Dixon. 1981. Subclass-restricted IgG polyclonal antibody production in mice injected with lipid A-rich lipopolysaccharides. J. Exp. Med. 153:324.
9. Watson, J., and R. Riblet. 1974. Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic responses to lipopolysaccharides. J. Exp. Med. 140:1147.
10. 125I-labeled DNA binding test. Elimination of nonspecific binding of DNA to non-immunoglobulin proteins by using an anionic detergent. Clin. Exp. Immunol. 26:425.
11. Theofilopoulos, A. N., C. B. Wilson, and F. J. Dixon. 1976. The Raji cell radioimmune assay for detecting immune complexes in human sera. J. Clin. Invest. 57:169.
12. Izui, S., P. J. McConahey, A. N. Theofilopoulos, and F. J. Dixon. 1979. Association of circulating retroviral gp70 anti-gp70 immune complexes with murine systemic lupus erythematosus. J. Exp. Med. 149:1099.
13. Mancini, G., A. Carbonara, and J. Heremans. 1965. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 2:235.
14. Slack, J., G. P. Der-Balian, M. Nahm, and J. M. Davie. 1980. Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and 9 type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency. J. Exp. Med. 151:853.
15. Marder, V. J., N. R. Shulman, and W. R. Carrol. 1969. High molecular weight derivatives of human fibrinogen produced by plasmin. J. Biol. Chem. 244: 111.
16. Doolittle, R. S., D. Schubert, and S. A. Schwartz. 1967. Amino acid sequence studies on artiodactyl fibrinopeptides. Arch. Biochem. Biophys. 118:456.
17. Goldman, M., L. M. Rose, A. Hochmann, and P. H. Lambert. 1982. Deposition of idiotype-anti-idiotype immune complexes in renal glomeruli after polyclonal B cell activation. J. Exp. Med. 155:1385.
18. Smathers, P. A., B. J. Steinberg, J. P. Reeves, and A. D. Steinberg. 1982. Effects of polyclonal immune stimulators upon NZB xid congenic mice. J. Immunol. 128:1414.
19. Steinberg, B. J., P. A. Smathers, K. Frederiksen, and A. D. Steinberg. 1982. Ability of the xid gene to prevent autoimmunity in (NZB X NZW)Fi mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA. J Clin. Invest. 70:587.
20. Ohsugi, Y., M. E. Gershwin, A. Ahmed, R. R. Skelly, and D. R. Milich. 1982. Studies of congenitally immunologic mutant New Zealand mice. VI. Spontaneous and induced autoantibodies to red cells and DNA occur in New Zealand X-linked immunodeficient (xid) mice without phenotypic alterations of the xid gene or generalized polyclonal B cell activation. J. Immunol. 128:2220.
21. Hiernaux, J. R., P. J. Baker, C. Delisi, and J. A. Rudbach. 1981. Modulation of the immune response to lipopolysaccharide. J. Immunol. 128:1054.
22. Skidmore, B. J., J. M. Chiller, D. C. Morrison, and W. O. Weigle. 1975. Immunologic properties of bacterial lipopolysaccharide (LPS): Correlation between the mitogenic, adjuvant, and immunogenic activities. J. Immunol. 117:770.
23. Dixon, F. J., A. N. Theofilopoulos, S. Izui, and P. J. McConahey. 1980. Murine SLE-etiology and pathogeneis. In Immunology 80. M. Fougereau and J. Dausset, editors. Academic Press, Inc., London. 959.
24. Murphy, E. D., and J. B. Roths. 1979. Autoimmunity and lymphoproliferation: Induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice. In Genetic Control of Autoimmune Disease. N. R. Rose, P. E. Bigazzi, and N. L. Warner, editors. Elsevier/North-Holland, Inc., New York. 207-219.
25. Eisenberg, R. A., S. Izui, P. J. McConahey, L. Hang, C. J. Peters, A. N. Theofilopoulos, and F. J. Dixon. 1980. Male determined accelerated autoimmune disease in BXSB mice: Transfer by bone marrow and spleen cells. J. Immunol 125:1032.
26. Tonietti, G., M. B. A. Oldstone, and F. J. Dixon. 1970. The effect of induced chronic viral infections on the immunologic diseases of New Zealand mice. J. Exp. Med. 132:89.
27. Ness, D. B., S. Smith, J. A. Telcott, F. C. Grumet. 1976. T cell requirements for the expression of the lipopolysaccharide adjuvant effect in vivo: Evidence for a T cell-dependent and a T cell-independent mode of action. Eur. J. Immunol. 6:650.
28. Coutinho, A., and G. Moller. 1975. Thymus-independent B-cell induction and paralysis. Adv. Immunol. 21:113.
29. Scibienski, R. J., and M. E. Gershwin. 1977. Immunologic properties of protein-lipopoly-saccharide complexes. I. Antibody response of normal, thymectomized and nude mice to a lysozyme-lipopolysaccharide complex. J. Immunol. 119:504.
30. Sjoberg, O., J. Andersson, and G. Moller. 1972. Lipopolysaccharides can substitute for helper cells in the antibody response in vitro. Eur. J. Immunol. 2:326.
31. Theofilopoulos, A. N., D. L. Shawler, R. A. Eisenberg, and F. J. Dixon. 1980. Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice. J. Exp. Med. 151:446.
32. Theofilopoulos, A. N., R. S. Balderas, D. L. Shawler, S. Lee, and F. J. Dixon. 1981. Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice. J. Exp. Med. 153:1405.
33. Andrews, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F.J. Dixon. 1978. Spontaneous murine lupuslike syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
34. Accini, L., and F. J. Dixon. 1979. Degenerative vascular disease and myocardial infarction in mice with lupus-like syndrome. Am. J. Path. 96:477.