N-METHYL-THIO-TETRAZOLE INHIBITION OF THE GAMMA CARBOXYLATION OF GLUTAMIC ACID: POSSIBLE MECHANISM FOR ANTIBIOTIC-ASSOCIATED HYPOPROTHROMBINAEMIA

The Lancet

Volumn 322, Issue 8343, 1983, Pages 192-193

  Lipsky, JamesJ ^a  

^a Division of Clinical Pharmacology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 5 TETRAZOLETHIOL; ANTIBIOTIC AGENT; CEFAMANDOLE; CEFOPERAZONE; CEPHALOSPORIN; GLUTAMIC ACID; LATAMOXEF; PROTHROMBIN;

ADVERSE DRUG REACTION; BLOOD AND HEMOPOIETIC SYSTEM; CARBOXYLATION; DRUG DEGRADATION; DRUG METABOLISM; ETIOLOGY; HUMAN; HYPOPROTHROMBINEMIA;

ANIMAL; ANTIBIOTICS; AZOLES; BACTERIA; BIOTRANSFORMATION; CEFAMANDOLE; CEFOPERAZONE; CEPHALOSPORINS; CEPHAMYCINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMATES; GLUTAMIC ACID; HUMAN; HYPOPROTHROMBINEMIAS; INTESTINES; MOXALACTAM; PROTHROMBIN; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TETRAZOLES;

EID: 0020629963     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(83)90174-5     Document Type: Article

References (13)

1. Gastrointestinal bleeding due to vitamin K deficiency in patients on parenteral cefamandole
2. Prolonged bleeding times and bleeding diathesis associated with moxalactam administration
3. Vitamin K deficiency developing in patients with renal failure treated with cephalosporin antibiotics
4. Bleeding in patients with infections
5. 1) in man
6. Hypoprothrombinemia and platelet dysfunction caused by cephalosporin and oxalactam antibiotics
7. The in vitro activity, human pharmacology and clinical effectiveness of new beta-lactam antibiotics
8. Partial sequence of rat prothrombin and the activity of two related pentapeptides as substrates for the vitamin K-dependent carboxylase system
9. Anticoagulant effects of cephalosporins, salicylate, and tibrynafen in relation to enzymes of vitamin K metabolism
10. Electronic structures of cephalosporins and penicillins. 9. Departure of a leaving group in cephalosporins
11. Absorption, distribution, excretion and metabolism (of cefmetazole)
12. Vitamin K-dependent carboxylase: requirements for carboxylation of soluble peptide substrates and substrate specificity
13. Hypoprothrombinaemic bleeding associated with ceftriaxone