Activation of macrophages by substance P: Induction of oxidative burst and thromboxane release

European Journal of Pharmacology

Volumn 89, Issue 3-4, 1983, Pages 301-305

  Hartung, Hans P ^a   Toyka, Klaus V ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Arachidonic acid metabolism; Macrophages; Oxidative burst; Substance P

Indexed keywords

SUBSTANCE P;

GUINEA PIG; MACROPHAGE;

ANIMAL; ARACHIDONIC ACIDS; ASCITIC FLUID; CELLS, CULTURED; GUINEA PIGS; HYDROGEN PEROXIDE; MACROPHAGE ACTIVATION; OXYGEN CONSUMPTION; SUBSTANCE P; SUPPORT, NON-U.S. GOV'T; THROMBOXANE B2; THROMBOXANES;

EID: 0020626578     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(83)90511-3     Document Type: Article

References (11)

1. Enhancement of phagocytosis - a newly found activity of Substance P residing in its N-terminal tetrapeptide sequence
2. 4 induce prostaglandin and thromboxane release from peritoneal macrophages
3. Membrane perturbation and stimulation of arachidonic acid metabolism
4. Induction of thromboxane release from macrophages by anaphylatoxic peptide C3a of complement and synthetic hexapeptide C3a72-77
5. Stimulation of prostaglandin E and thromboxane synthesis in macrophages by purified C3b
6. Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages
7. Substance P
8. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
9. The platelet as an inflammatory cell
10. Phagocyte-generated oxygen metabolites and cellular injury
11. Quantitative studies of the secretion of complement component C3 by resident, elicited and activated macrophages. Comparison with C2, C4 and lysosomal enzyme release