α-Adrenoreceptor Reagents. 1. Synthesis of Some 1,4-Benzodioxans as Selective Presynaptic a2-Adrenoreceptor Antagonists and Potential Antidepressants

Journal of Medicinal Chemistry

Volumn 26, Issue 6, 1983, Pages 823-831

  Chapleo, Christopher B ^a   Myers, Peter L ^a   Butler, Richard C M ^a   Doxey, John C ^a   Roach, Alan G ^a   Smith, Colin F C ^a  

^a Reckitt & Colman   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZODIOXAN; 17BETA HYDROXY 11BETA (4 METHOXYPHENYL) 19 NOR 17ALPHA PREGNA 4,9 DIEN 20 YN 3 ONE; ALPHA ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; ANTIMIGRAINE AGENT; CLONIDINE; IDAZOXAN; IDAZOXAN DERIVATIVE; NEW DRUG; PHENTOLAMINE; PHENYLEPHRINE; PIPEROXAN; PRAZOSIN; RAUWOLSCINE; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL CELL; ARTICLE; DEPRESSION; DOSE RESPONSE; DRUG ANALYSIS; DRUG ANTAGONISM; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG POTENTIATION; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; GREAT BLOOD VESSEL; MALE GENITAL SYSTEM; MOUSE; MUSCLE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIDEPRESSIVE AGENTS; DIOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; IDAZOXAN; MALE; MICE; PHENYLEPHRINE; RATS; RATS, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPSES; VAS DEFERENS;

EID: 0020615359     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00360a008     Document Type: Article

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