Morphological and Biochemical Characterization of Four Clonal Osteogenic Sarcoma Cell Lines of Rat Origin

Cancer Research

Volumn 43, Issue 9, 1983, Pages 4308-4314

  Partridge, Nicola C ^a,a   Alcorn, Daine ^a   Michelangeli, Valdo P ^a   Ryan, Graeme ^a   Martin, T John ^a,a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALKALINE PHOSPHATASE; PARATHYROID HORMONE;

BONE; CYTOLOGY; IN VITRO STUDY; MORPHOLOGY; NONHUMAN; OSTEOSARCOMA; RAT;

ACID PHOSPHATASE; ADENYLATE CYCLASE; ALKALINE PHOSPHATASE; ANIMALS; CALCITONIN; CELL LINE; CLONE CELLS; DINOPROSTONE; ENZYME ACTIVATION; KINETICS; MICROSCOPY, ELECTRON; OSTEOSARCOMA; PARATHYROID HORMONE; PROSTAGLANDINS E; RATS; SARCOMA, EXPERIMENTAL;

EID: 0020562941     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Atkins, D., Hunt, N. H., Ingleton, P. M., and Martin, T. J. Rat osteogenic sarcoma cells: isolation and effects of hormones on the production of cyclic AMP and cyclic GMP. Endocrinology, 101: 555–561,1977.
2. Atkins, D., and Martin, T. J. Rat osteogenic sarcoma cells: effects of some prostaglandins, their metabolites and analogues on cyclic AMP production. Prostaglandins, 13; 861–871,1977.
3. Atkins, D., Waller, P. C., and Martin, T. J. Rat osteogenic sarcoma cells: modulation of hormone stimulated cyclic AMP production by prostaglandin antagonists and biosynthesis inhibitors. Clin. Exp. Pharmacol. Physiol., 7; 31–44,1980.
4. Bradley, T. R., Hodgson, G. S., and Rosendaal, M. The effect of oxygen tension on haemopoietic and fibroblast cell proliferation in vitro. J. Cell. Physiol., 97: 517–522,1978.
5. Coulton, L. A., Ingleton, P. M., Preston, C. J., Brocklehurst, D., and Martin, T. J. Production of alkaline phosphatase by a rat osteogenic sarcoma in vivo and in vitro. Trans. Biochem. Soc., 6:239–241,1978.
6. Crawford, A., Atkins, D., and Martin, T. J. Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, l2 (prostacyclin), 6 keto F1a, and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. Biochem. Biophys. Res. Commun., 82:1195–1201,1978.
7. Crawford, A., Hunt, N. H., Dawbom, J. K., Michelangeli, V. P., and Martin, T. J. Membranes from a transplantable osteogenic sarcoma responsive to parathyroid hormone and prostaglandins: regulation of adenylate cyclase and of hormone metabolism. J. Endocrinol., 77:213–224,1978.
8. Hunt, N. H., Martin, T. J., Michelangeli, V. P., and Eisman, J. A. Effect of guanyl nucleotides on parathyroid hormone-responsive adenylate cyclase in chick kidney. J. Endocrinol., 69: 401–412,1976.
9. Ingleton, P. M., Coulton, L. A., Preston, C. J., and Martin, T. J. Alkaline phosphatase in serum and tumour of rats bearing a hormone-responsive transplantable osteogenic sarcoma. Eur. J. Cancer, 15:685–691,1979.
10. Ingleton, P. M., Underwood, J. C. E., Hunt, N. H., Atkins. D., Giles, B., Coulton, L. A., and Martin, T. J. Radiation induced osteogenic sarcoma in the rat as a model of hormone-responsive differentiated cancer. Lab. Anim. Sci., 27:748756,1977.
11. Jeffree, G. M., and Price, C. H. G. Bone tumours and their enzymes. J. Bone Jt. Surg. Br. Vol., 47:120–136,1965.
12. Livesey, S. A., Kemp, B. E., Re, C. A., Partridge, N. C., and Martin, T. J. Selective hormonal activation of cyclic AMP-dependent protein kinase isoenzymes in normal and malignant osteoblasts. J. Biol. Chem., 257: 14983–14987,1982.
13. Luben, R. A., Wong, G. L., and Cohn, D. V. Biochemical characterization with parathormone and calcitonin of isolated bone cells: provisional identification of osteoclasts and osteoblasts. Endocrinology, 99:526–534,1979.
14. Majeska, R. J., Rodan, S. B., and Rodan, G. A. Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma. Endocrinology, 107:1494–1505, 1980.
15. Manolagos, S. C., Haussler, M. R., and Deftos, L. J. 1,25-dihydroxyvitamin D3 receptor-like macromolecule in rat osteogenic sarcoma cell lines. J. Biol. Chem., 255: 8382–8388,1980.
16. Martin, T. J., Crawford, A., Coulton, L., Atkins, D., Hunt, N. H., Dawbom, J. K., Ingleton, P., and Underwood, J. C. E. Metabolic properties of hormonally responsive osteogenic sarcoma cells, in: R. V. Talmage (ed.), Endocrinology of Calcium Metabolism, pp. 264–269. Amsterdam: Excerpta Medica, 1977.
17. Martin, T. J., Ingleton, P. M., Coulton, L. A., and Melick, R. A. Metabolic properties of hormonally responsive osteogenic sarcoma cells. Clin. Orthop. Relat. Res., 140: 247–254,1979.
18. Martin, T. J., Ingleton, P. M., Underwood, J. C. E., Melick, R. A., Michelangeli, V. P., and Hunt, N. H. Parathyroid hormone responsive adenylate cyclase in an induced transplantable osteogenic sarcoma in the rat. Nature (Lond.), 260: 436–438,1976.
19. Moseley, J. M., Martin, T. J., Robinson, C. J., Reit, B., and Tregear, G. W. Hormone metabolism and response of adenylate cyclase to parathyroid hormone in kidney. Clin. Exp. Pharmacol. Physiol., 2: 549–557,1975.
20. Ng, K. W., Partridge, N. C., Niall, M., and Martin, T. J. Epidermal growth factor receptors in clonal lines of a rat osteogenic sarcoma and in osteoblast-rich rat bone cells. Calcif. Tissue Int., 35:298–303,1983.
21. Ng, K. W., Partridge. N. C., Niall, M., and Martin, T. J. Stimulation of DNA synthesis by epidermal growth factor in osteoblast-like cells. Calcif. Tissue Int., in press, 1983.
22. Nolan, R. D., Partridge, N. C., Godfrey, H. M., and Martin, T. J. Cyclooxygenase products of arachidonic acid metabolism in rat osteoblasts in culture. Calcif. Tissue Int., 35:294–297,1983.
23. Partridge, N. C., Alcorn, D., Michelangeli. V. P., Kemp. B. E., Ryan. G. B., and Martin. T. J. Functional properties of hormonally responsive cultured normal and malignant rat osteoblastic cells. Endocrinology. 108:213–219,1981.
24. Partridge. N. C., Frampton. R. J., Eisman, J. A., Michelangeli, V. P., Elms. E., Bradley. T. R., and Martin, T. J. Receptors for 1,25(OH)2 vitamin D3 enriched in cloned osteoblast-like rat osteogenic sarcoma cells. FEBS Lett., 115:139–142,1980.
25. Partridge, N. C., Kemp, B. E., Livesey, S. A., and Martin, T. J. Activity ratio measurements reflect intracellular activation of cyclic AMP-dependent protein kinase in osteoblasts. Endocrinology, 111:178–183,1982.
26. Partridge, N. C., Kemp, B. E., Veroni, M. C., and Martin, T. J. Activation of cyclic AMP-dependent protein kinase in normal and malignant bone cells by parathyroid hormone, prostaglandin E2 and prostacyclin. Endocrinology, 108: 220–226,1981.
27. Prockop, D. J., Kivirikko, K. I., Tuderman, L., and Guzman. N. A. The biosynthesis of collagen and its disorders. I. N. Engl. J. Med., 301:13–23,1979.
28. Rodan, G. A., and Martin, T. J. Role of osteoblasts in hormonal control of bone resorption—a hypothesis. Calcif. Tissue Int., 33:349–351,1981.
29. Rodan, S. B., Rodan, G. A., Simmons, H. A., Wolenga, R. W., Feinstein, M. B., and Raisz, L. G. Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2. Biochem. Biophys. Res. Commun., 102: 1358–1365,1981.
30. Underwood, J. C. E., Melick, R. A., Dangerfield, V. M., Crawford, A., Coulton, L., Ingteton, P. M., Loomes, R. S., and Martin, T. J. Structural and functional correlations in parathyroid hormone responsive transplantable osteogenic sarcomas. Eur. J. Cancer, 15:1151–1158,1979.