Activity of Mitomycin C for Aerobic and Hypoxic Cells in Vitro and in Vivo

Cancer Research

Volumn 43, Issue 9, 1983, Pages 4154-4158

  Rauth, A Michael ^a   Mohindra, J K ^a   Tannock, Ian F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; MITOMYCIN; MITOMYCIN C;

BREAST; BREAST CANCER; CELL CULTURE; FEMALE GENITAL SYSTEM; FIBROSARCOMA; HAMSTER; HELA CELL; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; NONHUMAN; RADIOTHERAPY; THERAPY;

AEROBIOSIS; ANAEROBIOSIS; ANIMAL; ANTIBIOTICS, ANTINEOPLASTIC; CELL DIVISION; CELL LINE; CELL SURVIVAL; CRICETULUS; FEMALE; HAMSTERS; HELA CELLS; HUMAN; KINETICS; LUNG; MICE; MITOMYCIN; MITOMYCINS; OVARY; SUPPORT, NON-U.S. GOV'T;

EID: 0020556148     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Corbett, T. H., Griswold, D. P., Jr., Roberts, B. J., Peckham, J. C., and Schabel, F. M., Jr. Biology and therapeutic response of a mouse mammary adenocarcinoma and its potential as a model for surgical adjuvant chemotherapy. Cancer Treat. Rep., 62:1471–1488,1978.
2. Crooke, S. T., and Bradner, W. T. Mitomycin C: a review. Cancer Treat. Rev., 3:121–139,1976.
3. Cummings, B. J., Rider, W. R., Harwood, A. R., Keane, T. J., Thomas, G., Erlichman, C., and Fine, S. Combined radical radiation therapy and chemotherapy for primary squamous cell carcinoma of the anal canal. Cancer Treat. Rep., 66: 489–492,1982.
4. Cunningham, J. R., Bruce, W. R., and Webb, H. P. A convenient 137Cs unit for irradiating cell suspensions and small laboratory animals. Phys. Med. Biol., 10: 381–384,1965.
5. Donelli, M. G., Broggini, M., Colombo, T., and Garattini, S. Importance of the presence of necrosis in studying drug distribution within a tumor tissue. Eur. J. Drug. Metab. Pharmacokinet., 2: 63–67,1977.
6. Goldacre, R. J. Viable tumor regions accessible to chemotherapeutic agents and a possible new strategy for inactivating them. Br. J. Cancer, 36:406–407, 1977.
7. Hill, R. P., and Bush, R. S. A lung colony assay to determine the radiosensitivity of the cells of a solid tumor. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 15: 435–444,1969.
8. Kennedy, K. A., Rockwell, S., and Sartorelli, A. C. Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res., 40: 2356–2360, 1980.
9. Nederman, T., Carlsson, J., and Mahmquist, M. Penetration of substances into tumor tissue—a methodological study on cellular spheroids. In Vitro (Rockville), 77:290–298,1981.
10. Ozols. R. F., Locker, G. Y., Doroshow, J. H., Grotzinger, K. R., Myers, C. E., and Young, R. C. Pharmacokinetics of Adriamycin and tissue penetration in murine ovarian cancer. Cancer Res., 39; 3209–3214,1979.
11. Rauth, A. M., Barton, B., and Lee, C. F. Y. Effects of caffeine on L-cells exposed to mitomycin C. Cancer Res., 30: 2724–2729,1970.
12. Rockwell, S. Cytotoxicities of mitomycin C and X-rays to aerobic and hypoxic cells in vitro. Int. J. Radiat. Oncol. Biol. Phys., 8:1035–1039,1982.
13. Rockwell, S., and Kennedy, K. A. Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys., 5:1673–1676,1979.
14. Siemann, D. W., Bronskill, M. J., Hi, R. P., and Bush, R. S. The relationship between mouse arterial partial pressure of oxygen (Pa O2) and the effectiveness of localized tumour irradiation. Br. J. Radiol., 48:662–667,1975.
15. Stanners, C. P., Eliceiri, G. L., and Green, H. Two types of ribosomes in mouse-hamster hybrid celts. Nat. New Biol., 230:52–54,1971.
16. Steel, G. G., and Peckham, M. J. Exploitable mechanisms in combined radio-therapy-chemotherapy: the concept of additivity. Int. J. Radiat. Oncol. Biol. Phys., 5: 85–91,1979.
17. Suit, H. D., and Shalek, R. J. Response of spontaneous mammary carcinoma of the C3H mouse to X-irradiation given under conditions of local tissue anoxia. J. Natl. Cancer Inst., 31:497–509,1963.
18. Sutherland, R. M., Eddy, H. A., Bareham, B., Reich, K., and Vanantwerp, D. Resistance to Adriamydn in multicellular spheroids. Int. J. Radiat. Oncol. Biol. Phys., 5:1225–1230,1979.
19. Tannock, I. Response of aerobic and hypoxic cells in a solid tumor to Adria-mycin and cyclophosphamide, and interaction of the drugs with radiation. Cancer Res., 42:4921–4926, 1982.
20. Taylor, Y. C., and Rauth, A. M. Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07–0582) in HeLa and Chinese hamster ovary cells. Cancer Res., 38:2745–2752,1978.
21. Teicher, B. A., Lago, J. S., and Sartorelli, A. C. Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res., 41:73–81,1981.
22. Thomson, J. E., and Rauth, A. M. An in vitro assay to measure the viability of KHT tumor cells not previously exposed to culture conditions. Radiat. Res., 58: 262–276,1974.
23. West, G. W., Weichselbaum, R., and Little, J. B. Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. Cancer Res., 40: 3665–3668,1980.
24. Whillans, D. W., and Rauth, A. M. An experimental and analytic approach to oxygen depletion in stirred cell suspensions. Radiat. Res., 84:97–114,1980.