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Volumn 309, Issue 18, 1983, Pages 1094-1104

The Pharmacology and Clinical Use of Methotrexate

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; CYTARABINE; FLUOROURACIL; METHOTREXATE; TIOGUANINE; VINCRISTINE;

EID: 0020554087     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198311033091805     Document Type: Review
Times cited : (682)

References (155)
  • 3
    • 0018871617 scopus 로고
    • Bone-marrow ablation and allogeneic marrow transplantation in acute leukemia
    • Blume KG. Beutler E, Brass KJ, et al. Bone-marrow ablation and allogeneic marrow transplantation in acute leukemia. N Engl J Med 1980; 302: 1041–1046.
    • (1980) N Engl J Med , vol.302 , pp. 1041-1046
    • Blume, K.G.1    Beutler, E.2    Brass, K.J.3
  • 4
    • 0019967036 scopus 로고
    • Methotrexate: a perspective of its use in the treatment of rheumatic diseases
    • Willkens RF, Watson MA. Methotrexate: a perspective of its use in the treatment of rheumatic diseases. J Lab Clin Med 1982; 100: 314–321.
    • (1982) J Lab Clin Med , vol.100 , pp. 314-321
    • Willkens, R.F.1    Watson, M.A.2
  • 5
    • 0019332584 scopus 로고
    • Enzymatic synthesis of folylpolyglutamates: characterization of the reaction and its products
    • McGuire JJ, Hsieh P. Coward JK, Bertino JR. Enzymatic synthesis of folylpolyglutamates: characterization of the reaction and its products. J Biol Chem 1980; 255: 5776–5788.
    • (1980) J Biol Chem , vol.255 , pp. 5776-5788
    • McGuire, J.J.1    Hsieh, P.2    Coward, J.K.3    Bertino, J.R.4
  • 6
    • 0019777280 scopus 로고
    • Enzymatic synthesis and function of folylpolyglutamates
    • McGuire JJ, Bertino JR. Enzymatic synthesis and function of folylpolyglutamates. Mol Cell Biochem 1981; 38: 19–48.
    • (1981) Mol Cell Biochem , vol.38 , pp. 19-48
    • McGuire, J.J.1    Bertino, J.R.2
  • 7
    • 0007377202 scopus 로고
    • The biochemical, cellular, and pharmacological action and effects of the folic acid antagonists
    • Werkheiser WC. The biochemical, cellular, and pharmacological action and effects of the folic acid antagonists. Cancer Res 1963; 23: 1277–1285.
    • (1963) Cancer Res , vol.23 , pp. 1277-1285
    • Werkheiser, W.C.1
  • 8
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin)
    • Farber S, Diamond LK, Mercer RD, Sylvester RF Jr., Wolff JA. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin). N Engl J Med 1948; 238: 787–793.
    • (1948) N Engl J Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2    Mercer, R.D.3    Sylvester, R.F.4    Wolff, J.A.5
  • 9
    • 0014410041 scopus 로고
    • Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell
    • Goldman ID, Lichtenstein NS, Oliverio VT. Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell. J Biol Chem 1978; 243: 5007–5017.
    • (1978) J Biol Chem , vol.243 , pp. 5007-5017
    • Goldman, I.D.1    Lichtenstein, N.S.2    Oliverio, V.T.3
  • 10
    • 0016706914 scopus 로고
    • Membrane transport of methotrexate in human neoplastic cells
    • Bender RA. Membrane transport of methotrexate in human neoplastic cells. Cancer Chemother Rep 1975; 6: 73–82.
    • (1975) Cancer Chemother Rep , vol.6 , pp. 73-82
    • Bender, R.A.1
  • 11
    • 0019409976 scopus 로고
    • Characteristics of membrane transport of methotrexate by cultured human breast cancer cells
    • Schilsky RL, Bailey BD, Chabner BA. Characteristics of membrane transport of methotrexate by cultured human breast cancer cells. Biochem Pharmacol 1981;30: 1537–1542.
    • (1981) Biochem Pharmacol , vol.30 , pp. 1537-1542
    • Schilsky, R.L.1    Bailey, B.D.2    Chabner, B.A.3
  • 12
    • 0018148658 scopus 로고
    • Membrane transport of methotrexate in human lymphoblastoid cells
    • Warren RD, Nichols AP, Bender RA. Membrane transport of methotrexate in human lymphoblastoid cells. Cancer Res 1978; 38: 668–671.
    • (1978) Cancer Res , vol.38 , pp. 668-671
    • Warren, R.D.1    Nichols, A.P.2    Bender, R.A.3
  • 13
    • 0018747876 scopus 로고
    • Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate
    • Hill BT, Bailey BD, White JC, Goldman ID. Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate. Cancer Res 1979; 39: 2440–2446.
    • (1979) Cancer Res , vol.39 , pp. 2440-2446
    • Hill, B.T.1    Bailey, B.D.2    White, J.C.3    Goldman, I.D.4
  • 14
    • 0019495233 scopus 로고
    • Phase I clinical trial and pharmacology of 2,4-diammino-5-(3′4′-dichlorophenyl)6-methylpyrimidine (metoprine) and folinic acid
    • de Jager R, Dupont D, Rodzynek J-J, Dorlet C, Lagrange G. Phase I clinical trial and pharmacology of 2,4-diammino-5-(3′4′-dichlorophenyl)6-methylpyrimidine (metoprine) and folinic acid. Cancer Chemother Pharmacol 1981;6: 75–80.
    • (1981) Cancer Chemother Pharmacol , vol.6 , pp. 75-80
    • de Jager, R.1    Dupont, D.2    Rodzynek, J.-J.3    Dorlet, C.4    Lagrange, G.5
  • 15
    • 0019518642 scopus 로고
    • Phase II clinical trial of DDMP (2,4diammino–5-(3′4′-dichlorophenyl)-6-methylpyrimidine) and folinic acid in solid tumors
    • de Jager R, Brugarolas A, Hansen M. Phase II clinical trial of DDMP (2,4diammino–5-(3′4′-dichlorophenyl)-6-methylpyrimidine) and folinic acid in solid tumors. Cancer Chemother Pharmacol 1981; 6: 81–84.
    • (1981) Cancer Chemother Pharmacol , vol.6 , pp. 81-84
    • de Jager, R.1    Brugarolas, A.2    Hansen, M.3
  • 16
    • 0018682878 scopus 로고
    • Role of thymidylate synthetase activity in development of methotrexate cytotoxicity
    • Moran RG, Mulkins M. Heidelberger C. Role of thymidylate synthetase activity in development of methotrexate cytotoxicity. Proc Natl Acad Sci USA 1979; 76: 5924–5928.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 5924-5928
    • Moran, R.G.1    Mulkins, M.2    Heidelberger, C.3
  • 17
    • 0019732978 scopus 로고
    • Methotrexate resistance in an L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport: computer simulations based on network thermodynamics
    • White JC, Goldman ID. Methotrexate resistance in an L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport: computer simulations based on network thermodynamics. J Biol Chem 1981; 256: 5722–5727.
    • (1981) J Biol Chem , vol.256 , pp. 5722-5727
    • White, J.C.1    Goldman, I.D.2
  • 18
    • 0019493835 scopus 로고
    • Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells
    • Ayusawa D, Koyama H, Seno T. Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells. Cancer Res 1981;41: 1497–1501.
    • (1981) Cancer Res , vol.41 , pp. 1497-1501
    • Ayusawa, D.1    Koyama, H.2    Seno, T.3
  • 19
    • 0020067869 scopus 로고
    • Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells
    • Washtien WL. Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells. Mol Pharmacol 1982; 21: 723–728.
    • (1982) Mol Pharmacol , vol.21 , pp. 723-728
    • Washtien, W.L.1
  • 20
    • 0018176299 scopus 로고
    • Reversibility of high-affinity binding of methotrexate in L1210 murine leukemia cells
    • Cohen M, Bender RA, Donehower RC, Myers CE, Chabner BA. Reversibility of high-affinity binding of methotrexate in L1210 murine leukemia cells. Cancer Res 1978; 38: 2866–2870.
    • (1978) Cancer Res , vol.38 , pp. 2866-2870
    • Cohen, M.1    Bender, R.A.2    Donehower, R.C.3    Myers, C.E.4    Chabner, B.A.5
  • 21
    • 0016806553 scopus 로고
    • The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of [l4C)formate incorporation into nucleic acids and protein
    • White JC, Loftfield S, Goldman ID. The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of [l4C)formate incorporation into nucleic acids and protein. Mol Pharmacol 1975; 11: 287–297.
    • (1975) Mol Pharmacol , vol.11 , pp. 287-297
    • White, J.C.1    Loftfield, S.2    Goldman, I.D.3
  • 22
    • 0018580281 scopus 로고
    • Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate: studies with pure enzyme and computer modeling using network thermodynamics
    • White JC. Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate: studies with pure enzyme and computer modeling using network thermodynamics. J Biol Chem 1979; 254: 10889–10895.
    • (1979) J Biol Chem , vol.254 , pp. 10889-10895
    • White, J.C.1
  • 23
    • 0015785010 scopus 로고
    • Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues
    • Chabner BA, Young RC. Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues. J Clin Invest 1973; 52: 1804–1811.
    • (1973) J Clin Invest , vol.52 , pp. 1804-1811
    • Chabner, B.A.1    Young, R.C.2
  • 24
    • 0019874666 scopus 로고
    • L(—)-10formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver
    • Smith GK, Benkovic PA, Benkovic SJ. L(—)-10formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver. Biochemistry 1981; 20: 4034–4036.
    • (1981) Biochemistry , vol.20 , pp. 4034-4036
    • Smith, G.K.1    Benkovic, P.A.2    Benkovic, S.J.3
  • 25
    • 0017405928 scopus 로고
    • Relative biochemical aspects of low and high doses of methotrexate in mice
    • Zaharko DS, Fung W-P, Yang K-H. Relative biochemical aspects of low and high doses of methotrexate in mice. Cancer Res 1977; 37: 1602–1607.
    • (1977) Cancer Res , vol.37 , pp. 1602-1607
    • Zaharko, D.S.1    Fung, W.-P.2    Yang, K.-H.3
  • 27
    • 0017597513 scopus 로고
    • Accumulation of methotrexate diglutamate in human liver during methotrexate therapy
    • Jacobs SA, Derr CJ, Johns DG. Accumulation of methotrexate diglutamate in human liver during methotrexate therapy. Biochem Pharmacol 1977; 26: 2310–2313.
    • (1977) Biochem Pharmacol , vol.26 , pp. 2310-2313
    • Jacobs, S.A.1    Derr, C.J.2    Johns, D.G.3
  • 28
    • 0016707310 scopus 로고
    • Tissue-specific synthesis of methotrexate polyglutamates in the rat
    • Whitehead VM, Perrault MM, Stelcner S. Tissue-specific synthesis of methotrexate polyglutamates in the rat. Cancer Res 1975; 35: 2985–2990.
    • (1975) Cancer Res , vol.35 , pp. 2985-2990
    • Whitehead, V.M.1    Perrault, M.M.2    Stelcner, S.3
  • 29
    • 0017344954 scopus 로고
    • Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells
    • Whitehead VM. Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells. Cancer Res 1977; 37: 408–412.
    • (1977) Cancer Res , vol.37 , pp. 408-412
    • Whitehead, V.M.1
  • 31
    • 0018831761 scopus 로고
    • Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells
    • Poser RG, Sirotnak FM, Chello PL. Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells. Biochem Pharmacol 1980; 29: 2701–2704.
    • (1980) Biochem Pharmacol , vol.29 , pp. 2701-2704
    • Poser, R.G.1    Sirotnak, F.M.2    Chello, P.L.3
  • 32
    • 0019800796 scopus 로고
    • Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo
    • Poser Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo. Cancer Res 1981; 41: 4441–4446.
    • (1981) Cancer Res , vol.41 , pp. 4441-4446
  • 33
    • 0018870416 scopus 로고
    • Synthesis of methotrexate polyglutamates by bone marrow cells from patients with leukemia and lymphoma
    • Witte A, Whitehead VM, Rosenblatt DS, Vuchich M-J. Synthesis of methotrexate polyglutamates by bone marrow cells from patients with leukemia and lymphoma. Dev Pharmacol Ther 1980; 1: 40–46.
    • (1980) Dev Pharmacol Ther , vol.1 , pp. 40-46
    • Witte, A.1    Whitehead, V.M.2    Rosenblatt, D.S.3    Vuchich, M.-J.4
  • 34
    • 0018866308 scopus 로고
    • Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes
    • Gewirtz DA, White JC, Randolph JK, Goldman ID. Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes. Cancer Res 1980; 40: 573–578.
    • (1980) Cancer Res , vol.40 , pp. 573-578
    • Gewirtz, D.A.1    White, J.C.2    Randolph, J.K.3    Goldman, I.D.4
  • 35
    • 0018874761 scopus 로고
    • Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate
    • Galivan J. Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate. Mol Pharmacol 1980; 17: 105–110.
    • (1980) Mol Pharmacol , vol.17 , pp. 105-110
    • Galivan, J.1
  • 36
    • 0020081481 scopus 로고
    • Rapid formation of poly-y-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro
    • Fry DW, Yalowich JC, Goldman ID. Rapid formation of poly-y-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro. J Biol Chem 1982; 257: 1890–1896.
    • (1982) J Biol Chem , vol.257 , pp. 1890-1896
    • Fry, D.W.1    Yalowich, J.C.2    Goldman, I.D.3
  • 37
    • 0020329348 scopus 로고
    • Separation and identification of subpicomole amounts of methotrexate polyglutamates in animal and human biopsy material
    • Krakower GR, Nylen PA, Kamen BA. Separation and identification of subpicomole amounts of methotrexate polyglutamates in animal and human biopsy material. Anal Biochem 1982; 122: 412–416.
    • (1982) Anal Biochem , vol.122 , pp. 412-416
    • Krakower, G.R.1    Nylen, P.A.2    Kamen, B.A.3
  • 38
    • 0019185971 scopus 로고
    • Methotrexate polyglutamate synthesis by cultured human breast cancer cells
    • Schilsky RL, Bailey BD, Chabner BA. Methotrexate polyglutamate synthesis by cultured human breast cancer cells. Proc Natl Acad Sci USA 1980;77: 2919–2922.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 2919-2922
    • Schilsky, R.L.1    Bailey, B.D.2    Chabner, B.A.3
  • 39
    • 0020334805 scopus 로고
    • The synthesis and retention of methotrexate polyglutamates in cultured human breast cancer cells
    • Jolivet J, Schilsky RL, Bailey BD, Chabner BA. The synthesis and retention of methotrexate polyglutamates in cultured human breast cancer cells. Ann NY Acad Sci 1982; 397: 184–192.
    • (1982) Ann NY Acad Sci , vol.397 , pp. 184-192
    • Jolivet, J.1    Schilsky, R.L.2    Bailey, B.D.3    Chabner, B.A.4
  • 40
    • 0019951735 scopus 로고
    • Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells
    • Jolivet J, Schilsky RL, Bailey BD, Drake JC, Chabner BA. Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells. J Clin Invest 1982; 70: 351–360.
    • (1982) J Clin Invest , vol.70 , pp. 351-360
    • Jolivet, J.1    Schilsky, R.L.2    Bailey, B.D.3    Drake, J.C.4    Chabner, B.A.5
  • 41
    • 85023659094 scopus 로고    scopus 로고
    • Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells: selective retention and less dissociable binding of 4–NH2–10-CH5-PteGlu4 and 5 to dihydrofolate reductase
    • (in press).
    • Jolivet J, Chabner BA. Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells: selective retention and less dissociable binding of 4–NH2–10-CH5-PteGlu4 and 5 to dihydrofolate reductase. J Clin Invest (in press).
    • J Clin Invest
    • Jolivet, J.1    Chabner, B.A.2
  • 42
    • 0016634038 scopus 로고
    • Stoichiometric inhibition of mammalian dihydrofolate reductase by the y-glutamyl metabolite of methotrexate: 4-amino-4-deoxy-Nm-methylpteroylglutamyl-y-glutamate
    • Jacobs SA, Adamson RH, Chabner BA, Derr CJ, Johns DG. Stoichiometric inhibition of mammalian dihydrofolate reductase by the y-glutamyl metabolite of methotrexate: 4-amino-4-deoxy-Nm-methylpteroylglutamyl-y-glutamate. Biochem Biophys Res Commun 1975; 63: 692–698.
    • (1975) Biochem Biophys Res Commun , vol.63 , pp. 692-698
    • Jacobs, S.A.1    Adamson, R.H.2    Chabner, B.A.3    Derr, C.J.4    Johns, D.G.5
  • 43
    • 84914529421 scopus 로고
    • Dihydrofolate reductase from a methotrexate-resistant human breast cancer cell line: purification, properties, and binding of methotrexate and polyglutamates
    • abstract.
    • Clendeninn NJ, Cowan KH, Kaufman BT, Nadkarni MV, Chabner BA. Dihydrofolate reductase from a methotrexate-resistant human breast cancer cell line: purification, properties, and binding of methotrexate and polyglutamates. Proc Am Assoc Cancer Res 1983; 24: 276. abstract.
    • (1983) Proc Am Assoc Cancer Res , vol.24 , pp. 276
    • Clendeninn, N.J.1    Cowan, K.H.2    Kaufman, B.T.3    Nadkarni, M.V.4    Chabner, B.A.5
  • 44
    • 0018230422 scopus 로고
    • Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells
    • Rosenblatt DS, Whitehead VM, Vera N, Pottier A, Dupont M, Vuchich M-J. Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells. Mol Pharmacol 1978; 14: 1143–1147.
    • (1978) Mol Pharmacol , vol.14 , pp. 1143-1147
    • Rosenblatt, D.S.1    Whitehead, V.M.2    Vera, N.3    Pottier, A.4    Dupont, M.5    Vuchich, M.-J.6
  • 45
    • 0019449889 scopus 로고
    • Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro
    • Balinska M, Galivan J, Coward JK. Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro. Cancer Res 1981; 41: 2751–2756.
    • (1981) Cancer Res , vol.41 , pp. 2751-2756
    • Balinska, M.1    Galivan, J.2    Coward, J.K.3
  • 46
    • 0018715411 scopus 로고
    • Human thymidylate synthetase. III. Effect of methotrexate and methotrexate analogs
    • Szeto DW, Cheng Y, Rosowsky A, et al. Human thymidylate synthetase. III. Effect of methotrexate and methotrexate analogs. Biochem Pharmacol 1977; 28: 2633–2637.
    • (1977) Biochem Pharmacol , vol.28 , pp. 2633-2637
    • Szeto, D.W.1    Cheng, Y.2    Rosowsky, A.3
  • 47
    • 84912578615 scopus 로고
    • Inhibition of purified avian liver aminoimidazole–carboxamide ribotide transformylase by polyglutamates of methotrexate and oxidized folates
    • abstract.
    • Baggott JE. Inhibition of purified avian liver aminoimidazole–carboxamide ribotide transformylase by polyglutamates of methotrexate and oxidized folates. Fed Proc 1983; 42: 667. abstract.
    • (1983) Fed Proc , vol.42 , pp. 667
    • Baggott, J.E.1
  • 48
    • 0019848289 scopus 로고
    • Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo
    • Sirotnak FM, Moccio DM, Kelleher LE, Goutas LJ. Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo. Cancer Res 1981; 41: 4447–4452.
    • (1981) Cancer Res , vol.41 , pp. 4447-4452
    • Sirotnak, F.M.1    Moccio, D.M.2    Kelleher, L.E.3    Goutas, L.J.4
  • 49
    • 0015948351 scopus 로고
    • Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells
    • Hanggi UJ, Littlefield JW. Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells. J Biol Chem 1974; 249: 1390–1397.
    • (1974) J Biol Chem , vol.249 , pp. 1390-1397
    • Hanggi, U.J.1    Littlefield, J.W.2
  • 50
    • 0019174166 scopus 로고
    • Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate
    • Flintoff WF, Essani K. Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate. Biochemistry 1980; 19: 4321–4327.
    • (1980) Biochemistry , vol.19 , pp. 4321-4327
    • Flintoff, W.F.1    Essani, K.2
  • 51
    • 0019817704 scopus 로고
    • Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts
    • Haber DA, Beverley SM, Kiely ML, Schimke RT. Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts. J Biol Chem 1981; 256: 9501–9510.
    • (1981) J Biol Chem , vol.256 , pp. 9501-9510
    • Haber, D.A.1    Beverley, S.M.2    Kiely, M.L.3    Schimke, R.T.4
  • 52
    • 0019130350 scopus 로고
    • Antifolate-resistantChinese hamster cells: evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases
    • Melera PW, Lewis JA, Biedler JL, Hession C. Antifolate-resistantChinese hamster cells: evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases. J Biol Chem 1980; 255: 7024–7028.
    • (1980) J Biol Chem , vol.255 , pp. 7024-7028
    • Melera, P.W.1    Lewis, J.A.2    Biedler, J.L.3    Hession, C.4
  • 53
    • 0019186331 scopus 로고
    • A methotrexate insensitive variant of folate reductase present in two lines of methotrexateresistant L5178Y cells
    • Goldie JH, Krystal G, Hartley D, Gudauskas G, Dedhar S. A methotrexate insensitive variant of folate reductase present in two lines of methotrexateresistant L5178Y cells. Eur J Cancer 1980; 16: 1539–1546.
    • (1980) Eur J Cancer , vol.16 , pp. 1539-1546
    • Goldie, J.H.1    Krystal, G.2    Hartley, D.3    Gudauskas, G.4    Dedhar, S.5
  • 54
    • 0017644532 scopus 로고
    • Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofolate reductase
    • Jackson RC, Niethammer D. Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofolate reductase. Eur J Cancer 1977; 13: 567–575.
    • (1977) Eur J Cancer , vol.13 , pp. 567-575
    • Jackson, R.C.1    Niethammer, D.2
  • 55
    • 0020580271 scopus 로고
    • Inhibition of a methotrexate-sensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines
    • Dedhar S, Freisheim JH, Hynes JB, Goldie JH. Inhibition of a methotrexate-sensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines. Biochem Pharmacol 1983; 32: 922–924.
    • (1983) Biochem Pharmacol , vol.32 , pp. 922-924
    • Dedhar, S.1    Freisheim, J.H.2    Hynes, J.B.3    Goldie, J.H.4
  • 56
    • 0014747361 scopus 로고
    • Amethopterin-induced changes in the multiple forms of dihydrofolate reductase from L1210 cells
    • Harding NGL, Martelli MF, Huennekens FM. Amethopterin-induced changes in the multiple forms of dihydrofolate reductase from L1210 cells. Arch Biochem Biophys 1970; 137: 295–296.
    • (1970) Arch Biochem Biophys , vol.137 , pp. 295-296
    • Harding, N.G.L.1    Martelli, M.F.2    Huennekens, F.M.3
  • 57
    • 0015364903 scopus 로고
    • Twodifferent species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin
    • Albrecht AM, Biedler JL, Hutchison DJ. Twodifferent species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin. Cancer Res 1972; 32: 1539–1546.
    • (1972) Cancer Res , vol.32 , pp. 1539-1546
    • Albrecht, A.M.1    Biedler, J.L.2    Hutchison, D.J.3
  • 58
    • 0015499957 scopus 로고
    • Purification, properties, and synthesis of dihydrofolate reductase from wild type and methotrexate-resistant hamster cells
    • Nakamura H, Littlefield JW. Purification, properties, and synthesis of dihydrofolate reductase from wild type and methotrexate-resistant hamster cells. J Biol Chem 1972; 247: 179–187.
    • (1972) J Biol Chem , vol.247 , pp. 179-187
    • Nakamura, H.1    Littlefield, J.W.2
  • 59
    • 0014451331 scopus 로고
    • Hybridization of hamster cells with high and low folate reductase activity
    • Littlefield JW. Hybridization of hamster cells with high and low folate reductase activity. Proc Natl Acad Sci USA 1969; 62: 88–95.
    • (1969) Proc Natl Acad Sci USA , vol.62 , pp. 88-95
    • Littlefield, J.W.1
  • 60
    • 0345075314 scopus 로고
    • Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells
    • Fischer GA. Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells. Biochem Pharmacol 1961; 7: 75–77.
    • (1961) Biochem Pharmacol , vol.7 , pp. 75-77
    • Fischer, G.A.1
  • 61
    • 0009605567 scopus 로고
    • Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells
    • Hakala MT, Zakrzewski SF, Nichol CA. Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells. J Biol Chem 1961; 236: 952–958.
    • (1961) J Biol Chem , vol.236 , pp. 952-958
    • Hakala, M.T.1    Zakrzewski, S.F.2    Nichol, C.A.3
  • 62
    • 0015252664 scopus 로고
    • Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro
    • Biedler JL, Albrecht AM, Hutchison DJ, Spengler BA. Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro. Cancer Res 1972; 32: 153–161.
    • (1972) Cancer Res , vol.32 , pp. 153-161
    • Biedler, J.L.1    Albrecht, A.M.2    Hutchison, D.J.3    Spengler, B.A.4
  • 63
    • 0017927963 scopus 로고
    • Biochemical and karyological properties of cells resistant to the quinazoline antifolate, methasquin
    • Biedler JL, Albrecht AM, Spengler BA. Biochemical and karyological properties of cells resistant to the quinazoline antifolate, methasquin. Eur J Cancer 1978; 14: 41–49.
    • (1978) Eur J Cancer , vol.14 , pp. 41-49
    • Biedler, J.L.1    Albrecht, A.M.2    Spengler, B.A.3
  • 64
    • 0018647262 scopus 로고
    • The development of resistance to methotrexate in a mouse melanoma cell line. I. Characterisation of the dihydrofolate reductases and chromosomes in sensitive and resistant cells
    • Bostock CJ, Clark EM, Harding NGL, et al. The development of resistance to methotrexate in a mouse melanoma cell line. I. Characterisation of the dihydrofolate reductases and chromosomes in sensitive and resistant cells. Chromosoma 1979; 74: 153–177.
    • (1979) Chromosoma , vol.74 , pp. 153-177
    • Bostock, C.J.1    Clark, E.M.2    Harding, N.G.L.3
  • 65
    • 0016585403 scopus 로고
    • Enzymic and transport mechanisms of amethopterin resistance in L1210 mouse cells
    • Jackson RC, Niethammer D. Huennekens FM. Enzymic and transport mechanisms of amethopterin resistance in L1210 mouse cells. Cancer Biochem Biophys 1975; 1: 151–155.
    • (1975) Cancer Biochem Biophys , vol.1 , pp. 151-155
    • Jackson, R.C.1    Niethammer, D.2    Huennekens, F.M.3
  • 66
    • 0017878104 scopus 로고
    • A methotrexate resistant subline of L1210 characterized by impaired transport of methotrexate, but not 5-methyl tetrahydrofolate
    • abstract.
    • Lindquist CA, Moroson BA, Bertino JR. A methotrexate resistant subline of L1210 characterized by impaired transport of methotrexate, but not 5-methyl tetrahydrofolate. Proc Am Assoc Cancer Res Am Soc Clin Oncol 1978; 19: 165. abstract.
    • (1978) Proc Am Assoc Cancer Res Am Soc Clin Oncol , vol.19 , pp. 165
    • Lindquist, C.A.1    Moroson, B.A.2    Bertino, J.R.3
  • 67
    • 0016958680 scopus 로고
    • Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells
    • Flintoff WF, Davidson SV, Siminovitch L. Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells. Somatic Cell Genet 1976; 2: 245–261.
    • (1976) Somatic Cell Genet , vol.2 , pp. 245-261
    • Flintoff, W.F.1    Davidson, S.V.2    Siminovitch, L.3
  • 68
    • 0017289341 scopus 로고
    • Metaphase chromosome anomaly: association with drug resistance and cell-specific products
    • Biedler JL, Spengler BA. Metaphase chromosome anomaly: association with drug resistance and cell-specific products. Science 1976; 191: 185–187.
    • (1976) Science , vol.191 , pp. 185-187
    • Biedler, J.L.1    Spengler, B.A.2
  • 69
    • 0017123099 scopus 로고
    • Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells
    • Alt FW, Kellems RE, Schimke RT. Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. J Biol Chem 1976; 251: 3063–3074.
    • (1976) J Biol Chem , vol.251 , pp. 3063-3074
    • Alt, F.W.1    Kellems, R.E.2    Schimke, R.T.3
  • 70
    • 0017174575 scopus 로고
    • Altered regulation of the rate of synthesis of dihydrofolate reductase in methotrexate-resistant hamster cells
    • Hänggi UJ, Littlefield JW. Altered regulation of the rate of synthesis of dihydrofolate reductase in methotrexate-resistant hamster cells. J Biol Chem 1976; 251: 3075–3080.
    • (1976) J Biol Chem , vol.251 , pp. 3075-3080
    • Hänggi, U.J.1    Littlefield, J.W.2
  • 71
    • 0017137269 scopus 로고
    • Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells: in vitro translation and characterization of folate reductase mRNA
    • Kellems RE, Alt FW, Schimke RT. Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells: in vitro translation and characterization of folate reductase mRNA. J Biol Chem 1976; 251: 6987–6993.
    • (1976) J Biol Chem , vol.251 , pp. 6987-6993
    • Kellems, R.E.1    Alt, F.W.2    Schimke, R.T.3
  • 72
    • 0017261390 scopus 로고
    • Elevated dihydrofolate reductase messenger mRNA levels in methotrexate-resistant BHK cells
    • Chang SE, Littlefield JW. Elevated dihydrofolate reductase messenger mRNA levels in methotrexate-resistant BHK cells. Cell 1976; 7: 391–396.
    • (1976) Cell , vol.7 , pp. 391-396
    • Chang, S.E.1    Littlefield, J.W.2
  • 73
    • 0017807188 scopus 로고
    • Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells
    • Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem 1978; 253: 1357–1370.
    • (1978) J Biol Chem , vol.253 , pp. 1357-1370
    • Alt, F.W.1    Kellems, R.E.2    Bertino, J.R.3    Schimke, R.T.4
  • 74
    • 0019849482 scopus 로고
    • Isolation and characterization of dihydrofolate acid reductase from methotrexate-sensitive and -resistant human cell lines
    • Morandi C, Attardi G. Isolation and characterization of dihydrofolate acid reductase from methotrexate-sensitive and -resistant human cell lines. J Biol Chem 1981; 256: 10169–10175.
    • (1981) J Biol Chem , vol.256 , pp. 10169-10175
    • Morandi, C.1    Attardi, G.2
  • 75
    • 0020040706 scopus 로고
    • Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells
    • Domin BA, Cheng Y, Hakala MT. Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells. Mol Pharmacol 1982; 21: 231–238.
    • (1982) Mol Pharmacol , vol.21 , pp. 231-238
    • Domin, B.A.1    Cheng, Y.2    Hakala, M.T.3
  • 76
    • 0020355516 scopus 로고
    • Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells
    • Cowan KH, Goldsmith ME, Levine RM, et al. Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells. J Biol Chem 1982; 257: 15079–15086.
    • (1982) J Biol Chem , vol.257 , pp. 15079-15086
    • Cowan, K.H.1    Goldsmith, M.E.2    Levine, R.M.3
  • 77
    • 0011815638 scopus 로고
    • Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes
    • Kaufman RJ, Brown PC, Schimke RT. Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proc Natl Acad Sci USA 1979; 76: 5669–5673.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 5669-5673
    • Kaufman, R.J.1    Brown, P.C.2    Schimke, R.T.3
  • 78
    • 0020691434 scopus 로고
    • Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes
    • Curt GA, Carney DN, Cowan KH, et al. Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes. N Engl J Med 1983; 308: 199–202.
    • (1983) N Engl J Med , vol.308 , pp. 199-202
    • Curt, G.A.1    Carney, D.N.2    Cowan, K.H.3
  • 79
    • 4244033996 scopus 로고
    • A novel mechanism of resistance to methotrexate in human breast cancer cells: lack of methotrexate polyglutamate formation
    • Cowan KH, Jolivet J. A novel mechanism of resistance to methotrexate in human breast cancer cells: lack of methotrexate polyglutamate formation. Clin Res 1983; 31: 508a.
    • (1983) Clin Res , vol.31 , pp. 508a
    • Cowan, K.H.1    Jolivet, J.2
  • 81
    • 0017358625 scopus 로고
    • The relative contribution of drug concentration and duration of exposure to mouse bone marrow toxicity during continuous methotrexate infusion
    • Pinedo HM, Zaharko DS, Bull J, Chabner BA. The relative contribution of drug concentration and duration of exposure to mouse bone marrow toxicity during continuous methotrexate infusion. Cancer Res 1977; 37: 445–450.
    • (1977) Cancer Res , vol.37 , pp. 445-450
    • Pinedo, H.M.1    Zaharko, D.S.2    Bull, J.3    Chabner, B.A.4
  • 82
    • 0018841396 scopus 로고
    • Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro
    • Eichholtz H, Trott K-R. Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro. Br J Cancer 1980; 41: 277–284.
    • (1980) Br J Cancer , vol.41 , pp. 277-284
    • Eichholtz, H.1    Trott, K.-R.2
  • 83
    • 0000336105 scopus 로고
    • Techniques for study of resistance to folic acid antagonists
    • Bertino JR, Fischer GA. Techniques for study of resistance to folic acid antagonists. Methods Med Res 1964; 10: 297–307.
    • (1964) Methods Med Res , vol.10 , pp. 297-307
    • Bertino, J.R.1    Fischer, G.A.2
  • 85
    • 0013580156 scopus 로고
    • Methods of measuring methotrexate in body fluids
    • In: Pinedo HM, ed. Amsterdam: Elsevier/North Holland
    • Bertino JR, Isacoff WH. Methods of measuring methotrexate in body fluids. In: Pinedo HM, ed. Clinical pharmacology of antineoplastic drugs. Amsterdam: Elsevier/North Holland, 1978:3–11.
    • (1978) Clinical pharmacology of antineoplastic drugs. , pp. 3-11
    • Bertino, J.R.1    Isacoff, W.H.2
  • 86
    • 84944431299 scopus 로고
    • Determination of methotrexate in serum by a rapid, fully mechanized enzyme in immunoassay (EMIT)
    • Oellerich M, Engelhardt P, Schaadt M, Diehl V. Determination of methotrexate in serum by a rapid, fully mechanized enzyme in immunoassay (EMIT). J Clin Chem Clin Biochem 1980; 18: 169–174.
    • (1980) J Clin Chem Clin Biochem , vol.18 , pp. 169-174
    • Oellerich, M.1    Engelhardt, P.2    Schaadt, M.3    Diehl, V.4
  • 87
    • 0018863416 scopus 로고
    • Methotrexate and 7-hydroxymethotrexate: serum level monitoring by high-performance liquid chromatography
    • Canfell C, Sadée W. Methotrexate and 7-hydroxymethotrexate: serum level monitoring by high-performance liquid chromatography. Cancer Treat Rep 1980; 64: 165–169.
    • (1980) Cancer Treat Rep , vol.64 , pp. 165-169
    • Canfell, C.1    Sadée, W.2
  • 88
    • 0019799409 scopus 로고
    • Methotrexate absorption in children with acute lymphoblastic leukemia
    • Craft AW, Rankin A, Aherne W. Methotrexate absorption in children with acute lymphoblastic leukemia. Cancer Treat Rep 1981; 65: Supplement 1: 77–81.
    • (1981) Cancer Treat Rep , vol.65 , pp. 77-81
    • Craft, A.W.1    Rankin, A.2    Aherne, W.3
  • 89
    • 0018729607 scopus 로고
    • Unpredictable serum levels after oral methotrexate in children with acute lymphoblastic leukaemia
    • Kearney PJ, Light PA, Preece A, Mott MG. Unpredictable serum levels after oral methotrexate in children with acute lymphoblastic leukaemia. Cancer Chemother Pharmacol 1979; 3: 117–120.
    • (1979) Cancer Chemother Pharmacol , vol.3 , pp. 117-120
    • Kearney, P.J.1    Light, P.A.2    Preece, A.3    Mott, M.G.4
  • 90
    • 0020611303 scopus 로고
    • Pharmacokinetics of oral methotrexate in children
    • Balis FM, Savitch JL, Bleyer WA. Pharmacokinetics of oral methotrexate in children. Cancer Res 1983; 43: 2342–2345.
    • (1983) Cancer Res , vol.43 , pp. 2342-2345
    • Balis, F.M.1    Savitch, J.L.2    Bleyer, W.A.3
  • 91
    • 0020358328 scopus 로고
    • Pharmacokinetics of low-dose methotrexate in children receiving maintenance therapy for acute lymphoblastic leukemia
    • Pinkerton CR, Welshman SG, Kelly JG, Shanks RG, Bridges JM. Pharmacokinetics of low-dose methotrexate in children receiving maintenance therapy for acute lymphoblastic leukemia. Cancer Chemother Pharmacol 1983; 10: 36–39.
    • (1983) Cancer Chemother Pharmacol , vol.10 , pp. 36-39
    • Pinkerton, C.R.1    Welshman, S.G.2    Kelly, J.G.3    Shanks, R.G.4    Bridges, J.M.5
  • 92
    • 0018837812 scopus 로고
    • Clinical pharmacology of intermediatedose oral methotrexate
    • Smith DK, Omura GA, Ostroy F. Clinical pharmacology of intermediatedose oral methotrexate. Cancer Chemother Pharmacol 1980; 4: 117–120.
    • (1980) Cancer Chemother Pharmacol , vol.4 , pp. 117-120
    • Smith, D.K.1    Omura, G.A.2    Ostroy, F.3
  • 93
    • 0016803892 scopus 로고
    • Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections
    • Shapiro WR, Young DF, Mehta BM. Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. N Engl J Med 1975; 293: 161–166.
    • (1975) N Engl J Med , vol.293 , pp. 161-166
    • Shapiro, W.R.1    Young, D.F.2    Mehta, B.M.3
  • 94
    • 0016288809 scopus 로고
    • Effect of route of administration and effusions on methotrexate pharmacokinetics
    • Wan SH, Huffman DH, Azarnoff DL, Stephens R, Hoogstraten B. Effect of route of administration and effusions on methotrexate pharmacokinetics. Cancer Res 1974; 34: 3487–3491.
    • (1974) Cancer Res , vol.34 , pp. 3487-3491
    • Wan, S.H.1    Huffman, D.H.2    Azarnoff, D.L.3    Stephens, R.4    Hoogstraten, B.5
  • 96
    • 0019378541 scopus 로고
    • Intrathecal methotrexate-induced neurotoxicities
    • Nelson RW, Frank JT. Intrathecal methotrexate-induced neurotoxicities. Am J Hosp Pharm 1981; 38: 65–68.
    • (1981) Am J Hosp Pharm , vol.38 , pp. 65-68
    • Nelson, R.W.1    Frank, J.T.2
  • 97
    • 0020680188 scopus 로고
    • Comparison of intermediatedose methotrexate with cranial irradiation for the post-incubation treatment of acute lymphocytic leukemia in children
    • Freeman AI, Weinberg V, Brecher ML, et al. Comparison of intermediatedose methotrexate with cranial irradiation for the post-incubation treatment of acute lymphocytic leukemia in children. N Engl J Med 1983; 308: 477–484.
    • (1983) N Engl J Med , vol.308 , pp. 477-484
    • Freeman, A.I.1    Weinberg, V.2    Brecher, M.L.3
  • 98
    • 0020622351 scopus 로고
    • Methotrexate cerebrospinal fluid and serum concentrations after intermediate-dose methotrexate infusion
    • Evans WE, Hutson PR, Stewart CF, et al. Methotrexate cerebrospinal fluid and serum concentrations after intermediate-dose methotrexate infusion. Clin Pharmacol Ther 1983; 33: 301–307.
    • (1983) Clin Pharmacol Ther , vol.33 , pp. 301-307
    • Evans, W.E.1    Hutson, P.R.2    Stewart, C.F.3
  • 99
    • 0005047577 scopus 로고
    • Influence of body position on ventricular cerebrospinal fluid methotrexate concentration following intralumbar administration
    • abstract.
    • Echelberger CK, Riccardi R, Bleyer A, Levine AS. Poplack DG. Influence of body position on ventricular cerebrospinal fluid methotrexate concentration following intralumbar administration. Proc Am Assoc Cancer Res Am Soc Clin Oncol 1981; 22: 365. abstract.
    • (1981) Proc Am Assoc Cancer Res Am Soc Clin Oncol , vol.22 , pp. 365
    • Echelberger, C.K.1    Riccardi, R.2    Bleyer, A.3    Levine, A.S.4    Poplack, D.G.5
  • 100
    • 0018700143 scopus 로고
    • Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism
    • Cadman E, Heimer R, Davis L. Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism. Science 1979;205: 1135–1137.
    • (1979) Science , vol.205 , pp. 1135-1137
    • Cadman, E.1    Heimer, R.2    Davis, L.3
  • 101
    • 0018088682 scopus 로고
    • Basis for fluoropyrimidine-induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro
    • Bowen D, White JC, Goldman ID. Basis for fluoropyrimidine-induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro. Cancer Res 1978; 38: 219–222.
    • (1978) Cancer Res , vol.38 , pp. 219-222
    • Bowen, D.1    White, J.C.2    Goldman, I.D.3
  • 102
    • 0001160855 scopus 로고
    • Schedule-dependent synergism and antagonism between methotrexate and asparaginase
    • Capizzi RL. Schedule-dependent synergism and antagonism between methotrexate and asparaginase. Biochem Pharmacol 1974; 23: Supplement 2: 151–161.
    • (1974) Biochem Pharmacol , vol.23 , pp. 151-161
    • Capizzi, R.L.1
  • 103
    • 0019763549 scopus 로고
    • Asparaginase-methotrexate in combination chemotherapy: scheduledependent differential effects on normal versus neoplastic cells
    • Capizzi RL. Asparaginase-methotrexate in combination chemotherapy: scheduledependent differential effects on normal versus neoplastic cells. Cancer Treat Rep 1981; 65: Supplement 4: 115–121.
    • (1981) Cancer Treat Rep , vol.65 , pp. 115-121
    • Capizzi, R.L.1
  • 104
    • 0018721428 scopus 로고
    • Mechanism of syncrgistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells
    • Cadman E, Eiferman P. Mechanism of syncrgistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells. J Clin Invest 1979; 64: 788–797.
    • (1979) J Clin Invest , vol.64 , pp. 788-797
    • Cadman, E.1    Eiferman, P.2
  • 105
    • 0018184873 scopus 로고
    • Lack of therapeutic synergism between vincristine and methotrexate in LI210 murine leukemia in vivo
    • Bender RA, Nichols AP, Norton L, Simon RM. Lack of therapeutic synergism between vincristine and methotrexate in LI210 murine leukemia in vivo. Cancer Treat Rep 1978; 62: 997–1003.
    • (1978) Cancer Treat Rep , vol.62 , pp. 997-1003
    • Bender, R.A.1    Nichols, A.P.2    Norton, L.3    Simon, R.M.4
  • 107
    • 0019818969 scopus 로고
    • Basis of observed resistance of L1210 leukemia in mice methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, 1-β-D-arabinofuranosylcytosine administered in different concentrations
    • Kim K, Blechman WJ, Riddle VGH, Pardee AB. Basis of observed resistance of L1210 leukemia in mice methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, 1-β-D-arabinofuranosylcytosine administered in different concentrations. Cancer Res 1981;41: 4529–4534.
    • (1981) Cancer Res , vol.41 , pp. 4529-4534
    • Kim, K.1    Blechman, W.J.2    Riddle, V.G.H.3    Pardee, A.B.4
  • 108
    • 0019425443 scopus 로고
    • Pharmacokinetics of leucovorin rescue using a new methotrexate-independent biochemical assay for leucovorin and N?-methyltetrahydrofolate
    • Hamel E, Johnson G, Glaubiger D. Pharmacokinetics of leucovorin rescue using a new methotrexate-independent biochemical assay for leucovorin and N?-methyltetrahydrofolate. Cancer Treat Rep 1981; 65: 545–553.
    • (1981) Cancer Treat Rep , vol.65 , pp. 545-553
    • Hamel, E.1    Johnson, G.2    Glaubiger, D.3
  • 109
    • 0020561386 scopus 로고
    • Effect of nitrous oxide on human cell lines
    • Kano Y, Sakamoto S. Sakuraya K, et al. Effect of nitrous oxide on human cell lines. Cancer Res 1983; 43: 1493–1496.
    • (1983) Cancer Res , vol.43 , pp. 1493-1496
    • Kano, Y.1    Sakamoto, S.2    Sakuraya, K.3
  • 110
    • 0020038231 scopus 로고
    • Methotrexate rescue by 5-methyltetrahydrofolate or 5-formyltetrahydrofolate in lymphoblast cell lines
    • Dudman NPB, Slowiaczek P, Tattersall MHN. Methotrexate rescue by 5-methyltetrahydrofolate or 5-formyltetrahydrofolate in lymphoblast cell lines. Cancer Res 1982; 42: 502–507.
    • (1982) Cancer Res , vol.42 , pp. 502-507
    • Dudman, N.P.B.1    Slowiaczek, P.2    Tattersall, M.H.N.3
  • 111
    • 0015031913 scopus 로고
    • Dihydrofolate reductase activity of leukemia L1210 during development of methotrexate resistance
    • Schrecker AW, Mead JAR, Greenberg WH, Goldin A. Dihydrofolate reductase activity of leukemia L1210 during development of methotrexate resistance. Biochem Pharmacol 1971; 20: 716–718.
    • (1971) Biochem Pharmacol , vol.20 , pp. 716-718
    • Schrecker, A.W.1    Mead, J.A.R.2    Greenberg, W.H.3    Goldin, A.4
  • 112
    • 0020658405 scopus 로고
    • Serum and cerebrospinal fluid distribution of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya methotrexate administration in patients with meningeal carcinomatosis
    • Mehta BM, Glass JP. Shapiro WR. Serum and cerebrospinal fluid distribution of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya methotrexate administration in patients with meningeal carcinomatosis. Cancer Res 1983; 43: 435–438.
    • (1983) Cancer Res , vol.43 , pp. 435-438
    • Mehta, B.M.1    Glass, J.P.2    Shapiro, W.R.3
  • 114
    • 0017259548 scopus 로고
    • 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate
    • Jacobs SA, Stoller RG, Chabner BA, Johns DG. 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate. J Clin Invest 1976; 57: 534–538.
    • (1976) J Clin Invest , vol.57 , pp. 534-538
    • Jacobs, S.A.1    Stoller, R.G.2    Chabner, B.A.3    Johns, D.G.4
  • 116
    • 0017380464 scopus 로고
    • High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity
    • Nirenberg A, Mosende C, Mehta BM. Gisolfi AL. Rosen G. High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity. Cancer Treat Rep 1977; 61: 779–783.
    • (1977) Cancer Treat Rep , vol.61 , pp. 779-783
    • Nirenberg, A.1    Mosende, C.2    Mehta, B.M.3    Gisolfi, A.L.4    Rosen, G.5
  • 119
    • 0018582258 scopus 로고
    • Pharmacokinetic monitoring of high-dose methotrexate: early recognition of high-risk patients
    • Evans WE, Pratt CB, Taylor RH, Barker LF, Crom WR. Pharmacokinetic monitoring of high-dose methotrexate: early recognition of high-risk patients. Cancer Chemother Pharmacol 1979; 3: 161–166.
    • (1979) Cancer Chemother Pharmacol , vol.3 , pp. 161-166
    • Evans, W.E.1    Pratt, C.B.2    Taylor, R.H.3    Barker, L.F.4    Crom, W.R.5
  • 122
    • 0018835874 scopus 로고
    • High-dose methotrexate with leucovorin rescue: rationale and spectrum of antitumor activity
    • Frei E III, Blum RH, Pitman SW, et al. High-dose methotrexate with leucovorin rescue: rationale and spectrum of antitumor activity. Am J Med 1980; 68: 370–376.
    • (1980) Am J Med , vol.68 , pp. 370-376
    • Frei, E.1    Blum, R.H.2    Pitman, S.W.3
  • 123
    • 2342506238 scopus 로고
    • High-dose methotrexate with citrovorum factor rescue: a new approach to cancer chemotherapy
    • In: Tagnon HJ. Staquet MJ, eds. Vol. 3. New York: Raven Press
    • Djerassi I, Kim JS, Nayak NP, Ohanissian H, Adler S. High-dose methotrexate with citrovorum factor rescue: a new approach to cancer chemotherapy. In: Tagnon HJ. Staquet MJ, eds. Recent advances in cancer treatment. Vol. 3. New York: Raven Press, 1977:201–225.
    • (1977) Recent advances in cancer treatment. , pp. 201-225
    • Djerassi, I.1    Kim, J.S.2    Nayak, N.P.3    Ohanissian, H.4    Adler, S.5
  • 124
    • 0018072993 scopus 로고
    • Phase II clinical trial with highdose methotrexate therapy and citrovorum factor rescue
    • Isacoff WH, Eilber F, Tabbarah H, et al. Phase II clinical trial with highdose methotrexate therapy and citrovorum factor rescue. Cancer Treat Rep 1978;62: 1295–1304.
    • (1978) Cancer Treat Rep , vol.62 , pp. 1295-1304
    • Isacoff, W.H.1    Eilber, F.2    Tabbarah, H.3
  • 125
    • 0017350847 scopus 로고
    • Weekly high-dose methotrexate-citrovorum factor in osteogenic sarcoma: pre-surgical treatment of primary tumor and of overt pulmonary metastases
    • Jaffe N, Frei E III, Traggis D, Watts H. Weekly high-dose methotrexate-citrovorum factor in osteogenic sarcoma: pre-surgical treatment of primary tumor and of overt pulmonary metastases. Cancer 1977; 39: 45–50.
    • (1977) Cancer , vol.39 , pp. 45-50
    • Jaffe, N.1    Frei, E.2    Traggis, D.3    Watts, H.4
  • 126
    • 0018876479 scopus 로고
    • High-dose methotrexate used alone and in combination for measurable primary or metastatic osteosarcoma
    • Pratt CB, Howarth C, Ransom JL, et al. High-dose methotrexate used alone and in combination for measurable primary or metastatic osteosarcoma. Cancer Treat Rep 1980; 64: 11–20.
    • (1980) Cancer Treat Rep , vol.64 , pp. 11-20
    • Pratt, C.B.1    Howarth, C.2    Ransom, J.L.3
  • 127
    • 0018650014 scopus 로고
    • Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery
    • Rosen G, Marcove RC, Caparros B, Nirenberg A, Kosloff C, Huyos AG. Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery. Cancer 1979; 43: 2163–2177.
    • (1979) Cancer , vol.43 , pp. 2163-2177
    • Rosen, G.1    Marcove, R.C.2    Caparros, B.3    Nirenberg, A.4    Kosloff, C.5    Huyos, A.G.6
  • 128
    • 0016242550 scopus 로고
    • Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma
    • Jaffe N, Frei E III, Traggis D, Bishop Y. Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. N Engl J Med 1971; 291: 994–997.
    • (1971) N Engl J Med , vol.291 , pp. 994-997
    • Jaffe, N.1    Frei, E.2    Traggis, D.3    Bishop, Y.4
  • 129
    • 0018647147 scopus 로고
    • Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation
    • Rosenberg SA, Chabner BA, Young RC, et al. Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation. Cancer Treat Rep 1979; 63: 739–751.
    • (1979) Cancer Treat Rep , vol.63 , pp. 739-751
    • Rosenberg, S.A.1    Chabner, B.A.2    Young, R.C.3
  • 130
    • 0018886575 scopus 로고
    • Methotrexate as adjuvant treatment for primary osteosarcoma
    • Edmonson JH, Green SJ, Wins JC, et al. Methotrexate as adjuvant treatment for primary osteosarcoma. N Engl J Med 1980; 303: 642–643.
    • (1980) N Engl J Med , vol.303 , pp. 642-643
    • Edmonson, J.H.1    Green, S.J.2    Wins, J.C.3
  • 131
    • 0019801740 scopus 로고
    • High-dose methotrexate in osteogenic sarcoma
    • Jaffe N, Link MP, Cohen D, et al. High-dose methotrexate in osteogenic sarcoma. Natl Cancer Inst Monogr 1981; 56: 201–206.
    • (1981) Natl Cancer Inst Monogr , vol.56 , pp. 201-206
    • Jaffe, N.1    Link, M.P.2    Cohen, D.3
  • 132
    • 0019920131 scopus 로고
    • Changing role of chemotherapy in treatment of head and neck cancer
    • Mead GM, Jacobs C. Changing role of chemotherapy in treatment of head and neck cancer. Am J Med 1982; 73: 582–595.
    • (1982) Am J Med , vol.73 , pp. 582-595
    • Mead, G.M.1    Jacobs, C.2
  • 133
    • 0020665885 scopus 로고
    • Chemotherapy in head and neck cancer
    • Hong WK, Bromer R. Chemotherapy in head and neck cancer. N Engl J Med 1983; 308: 75–79.
    • (1983) N Engl J Med , vol.308 , pp. 75-79
    • Hong, W.K.1    Bromer, R.2
  • 134
    • 0015641551 scopus 로고
    • Improved therapeutic index of methotrexate with “leucovorin rescue
    • Levitt M, Mosher MB, DeConti RC. et al. Improved therapeutic index of methotrexate with “leucovorin rescue.” Cancer Res 1973; 33: 1729–1734.
    • (1973) Cancer Res , vol.33 , pp. 1729-1734
    • Levitt, M.1    Mosher, M.B.2    DeConti, R.C.3
  • 135
    • 0019472047 scopus 로고
    • Methotrexate treatment of squamous-cell head and neck cancers: dose–response evaluation
    • Woods RL, Fox RM, Tattersall MHN. Methotrexate treatment of squamous-cell head and neck cancers: dose–response evaluation. Br Med J 1981;282: 600–602.
    • (1981) Br Med J , vol.282 , pp. 600-602
    • Woods, R.L.1    Fox, R.M.2    Tattersall, M.H.N.3
  • 136
    • 0019424537 scopus 로고
    • Increased therapeutic index using moderate dose methotrexate and leucovorin twice weekly vs. weekly high dose methotrexate-leucovorin in patients with advanced squamous carcinoma of the head and neck: a safe new effective program
    • Kirkwood JM, Canellos GP, Ervin TJ, Pitman SW, Weichselbaum R, Miller D. Increased therapeutic index using moderate dose methotrexate and leucovorin twice weekly vs. weekly high dose methotrexate-leucovorin in patients with advanced squamous carcinoma of the head and neck: a safe new effective program. Cancer 1981; 47: 2414–2421.
    • (1981) Cancer , vol.47 , pp. 2414-2421
    • Kirkwood, J.M.1    Canellos, G.P.2    Ervin, T.J.3    Pitman, S.W.4    Weichselbaum, R.5    Miller, D.6
  • 137
    • 0019501879 scopus 로고
    • A randomized prospective comparison of intermittent methotrexate, methotrexate with leucovorin, and a methotrexate combination in head and neck cancer
    • DeConti RC. Schoenfeld D. A randomized prospective comparison of intermittent methotrexate, methotrexate with leucovorin, and a methotrexate combination in head and neck cancer. Cancer 1981; 48: 1061–1072.
    • (1981) Cancer , vol.48 , pp. 1061-1072
    • DeConti, R.C.1    Schoenfeld, D.2
  • 138
    • 0019273060 scopus 로고
    • Phase II study of high-dose methotrexate in the treatment of patients with non-small carcinoma of the lung: an Eastern Cooperative Oncology Group Study
    • Ettinger DS, Stanley KE, Nystrom JS. Phase II study of high-dose methotrexate in the treatment of patients with non-small carcinoma of the lung: an Eastern Cooperative Oncology Group Study. Cancer Treat Rep 1980; 64: 1017–1021.
    • (1980) Cancer Treat Rep , vol.64 , pp. 1017-1021
    • Ettinger, D.S.1    Stanley, K.E.2    Nystrom, J.S.3
  • 139
    • 0019963307 scopus 로고
    • Lack of efficacy of highdose methotrexate by 30-hour infusion in patients with progressive small cell carcinoma of the lung
    • Ihde DC, Johnson-Early A, Carney DN, et al. Lack of efficacy of highdose methotrexate by 30-hour infusion in patients with progressive small cell carcinoma of the lung. Cancer Treat Rep 1982; 66: 1223–1225.
    • (1982) Cancer Treat Rep , vol.66 , pp. 1223-1225
    • Ihde, D.C.1    Johnson-Early, A.2    Carney, D.N.3
  • 140
    • 0019988689 scopus 로고
    • Randomized study of high-dose versus low-dose methotrexate in the treatment of extensive small cell lung cancer
    • Hande KR, Oldham RK, Fer MF, Richardson RL, Greco FA. Randomized study of high-dose versus low-dose methotrexate in the treatment of extensive small cell lung cancer. Am J Med 1982; 73: 413–419.
    • (1982) Am J Med , vol.73 , pp. 413-419
    • Hande, K.R.1    Oldham, R.K.2    Fer, M.F.3    Richardson, R.L.4    Greco, F.A.5
  • 141
    • 0018876325 scopus 로고
    • Cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine combination sequential chemotherapy for advanced diffuse histiocytic lymphoma
    • Sweet DL, Golomb HM, Ultmann JE, et al. Cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine combination sequential chemotherapy for advanced diffuse histiocytic lymphoma. Ann Intern Med 1980; 92: 785–790.
    • (1980) Ann Intern Med , vol.92 , pp. 785-790
    • Sweet, D.L.1    Golomb, H.M.2    Ultmann, J.E.3
  • 142
    • 0020676256 scopus 로고
    • Diffuse aggressive lymphomas: Increased survival after alternating flexible sequences of ProMACE and MOPP chemotherapy
    • Fisher RF. DeVita VT Jr., Hubbard SM, et al. Diffuse aggressive lymphomas: Increased survival after alternating flexible sequences of ProMACE and MOPP chemotherapy. Ann Intern Med 1983; 98: 304–309.
    • (1983) Ann Intern Med , vol.98 , pp. 304-309
    • Fisher, R.F.1    DeVita, V.T.2    Hubbard, S.M.3
  • 143
    • 0021088267 scopus 로고
    • Improved prognosis of diffuse histiocytic and undifferentiated lymphoma by use of high-dose methotrexate alternating with standard agents (M-BACOD)
    • Skarin AT, Canellos GP, Rosenthal DS, et al. Improved prognosis of diffuse histiocytic and undifferentiated lymphoma by use of high-dose methotrexate alternating with standard agents (M-BACOD). J Clin Oncol 1983; 1: 91–98.
    • (1983) J Clin Oncol , vol.1 , pp. 91-98
    • Skarin, A.T.1    Canellos, G.P.2    Rosenthal, D.S.3
  • 144
    • 0021067573 scopus 로고
    • Methotrexate-induced renal impairment: Clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine
    • Abelson HT, Fasburg MT, Beardsley GP, et al. Methotrexate-induced renal impairment: Clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine. J Clin Oncol 1983; 1: 208–216.
    • (1983) J Clin Oncol , vol.1 , pp. 208-216
    • Abelson, H.T.1    Fasburg, M.T.2    Beardsley, G.P.3
  • 145
    • 0019849385 scopus 로고
    • Ocular irritation from high-dose methotrexate therapy: pharmacokinetics of drug in the tear film
    • Doroshow JH, Locker GY, Gaasterland DE, Hubbard SP, Young RC, Myers CE. Ocular irritation from high-dose methotrexate therapy: pharmacokinetics of drug in the tear film. Center 1981; 48: 2158–2162.
    • (1981) Center , vol.48 , pp. 2158-2162
    • Doroshow, J.H.1    Locker, G.Y.2    Gaasterland, D.E.3    Hubbard, S.P.4    Young, R.C.5    Myers, C.E.6
  • 146
    • 0020522764 scopus 로고
    • Erythema and desquamation after high-dose methotrexate
    • Doyle LA, Berg C, Bottino G, Chabner BA. Erythema and desquamation after high-dose methotrexate. Ann Intern Med 1983; 98: 611–612.
    • (1983) Ann Intern Med , vol.98 , pp. 611-612
    • Doyle, L.A.1    Berg, C.2    Bottino, G.3    Chabner, B.A.4
  • 147
    • 0020680909 scopus 로고
    • Chemical pleuritis as the cause of acute chest pain following high-dose methotrexate treatment
    • Urban C, Nirenberg A, Caparros B, Anac S, Cacavio A, Rosen G. Chemical pleuritis as the cause of acute chest pain following high-dose methotrexate treatment. Cancer 1983; 51: 34–37.
    • (1983) Cancer , vol.51 , pp. 34-37
    • Urban, C.1    Nirenberg, A.2    Caparros, B.3    Anac, S.4    Cacavio, A.5    Rosen, G.6
  • 148
    • 0019451573 scopus 로고
    • Effects of highdose methotrexate and vincristine on ovarian and testicular functions in patients undergoing postoperative adjuvant treatment of osteosarcoma
    • Shamberger RC, Rosenberg SA, Seipp CA, Sherins RJ. Effects of highdose methotrexate and vincristine on ovarian and testicular functions in patients undergoing postoperative adjuvant treatment of osteosarcoma. Cancer Treat Rep 1981; 65: 739–746.
    • (1981) Cancer Treat Rep , vol.65 , pp. 739-746
    • Shamberger, R.C.1    Rosenberg, S.A.2    Seipp, C.A.3    Sherins, R.J.4
  • 149
    • 0020079351 scopus 로고
    • Evidence that at “high” extracellular methotrexate concentrations the transport barrier is unlikely to be an important mechanism of drug resistance
    • Hill BT, Dedhar S, Goldie JH. Evidence that at “high” extracellular methotrexate concentrations the transport barrier is unlikely to be an important mechanism of drug resistance. Biochem Pharmacol 1982; 31: 263–266.
    • (1982) Biochem Pharmacol , vol.31 , pp. 263-266
    • Hill, B.T.1    Dedhar, S.2    Goldie, J.H.3
  • 150
    • 0013812232 scopus 로고
    • The “induction” of leucocyte and erythrocyte dihydrofolate reductase by methotrexate. II. Clinical and pharmacologic studies
    • Bertino JR, Cashmore A, Fink M, Calabresi P, Lefkowitz E. The “induction” of leucocyte and erythrocyte dihydrofolate reductase by methotrexate. II. Clinical and pharmacologic studies. Clin Pharmacol Ther 1965; 6: 763–770.
    • (1965) Clin Pharmacol Ther , vol.6 , pp. 763-770
    • Bertino, J.R.1    Cashmore, A.2    Fink, M.3    Calabresi, P.4    Lefkowitz, E.5
  • 151
    • 0020004532 scopus 로고
    • Effect of methotrexate on dihydrofolate reductase activity in methotrexate-resistant human KB cells
    • Domin BA, Grill SP, Bastow KF, Cheng Y-C. Effect of methotrexate on dihydrofolate reductase activity in methotrexate-resistant human KB cells. Mol Pharmacol 1982; 21: 478–482.
    • (1982) Mol Pharmacol , vol.21 , pp. 478-482
    • Domin, B.A.1    Grill, S.P.2    Bastow, K.F.3    Cheng, Y.-C.4
  • 152
    • 84915665293 scopus 로고
    • The regulation of dihydrofolate reductase in gene-amplified methotrexate-resistant human breast cancer cells
    • abstract.
    • Jolivet J, Levine RM, Cowan KH. The regulation of dihydrofolate reductase in gene-amplified methotrexate-resistant human breast cancer cells. Clin Res 1983; 3L: 509A. abstract.
    • (1983) Clin Res , vol.3L , pp. 509A
    • Jolivet, J.1    Levine, R.M.2    Cowan, K.H.3
  • 153
    • 0017839684 scopus 로고
    • Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models
    • Sirotnak FM, Moccio DM, Dorick DM. Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models. Cancer Res 1978; 38: 345–353.
    • (1978) Cancer Res , vol.38 , pp. 345-353
    • Sirotnak, F.M.1    Moccio, D.M.2    Dorick, D.M.3
  • 154
    • 0020678331 scopus 로고
    • Effects of folinic acid on hepatoma cells containing methotrexate polyglutamates
    • Galivan J, Nimec Z. Effects of folinic acid on hepatoma cells containing methotrexate polyglutamates. Cancer Res 1983; 43: 551–555.
    • (1983) Cancer Res , vol.43 , pp. 551-555
    • Galivan, J.1    Nimec, Z.2
  • 155
    • 0018372880 scopus 로고
    • A clinical and pharmacological study of high-dose methotrexate with minimal leucovorin rescue
    • Stoller RG, Kaplan HG, Cummings FJ, Calabresi P. A clinical and pharmacological study of high-dose methotrexate with minimal leucovorin rescue. Cancer Res 1979; 39: 908–912.
    • (1979) Cancer Res , vol.39 , pp. 908-912
    • Stoller, R.G.1    Kaplan, H.G.2    Cummings, F.J.3    Calabresi, P.4


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