Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration

European Journal of Pharmacology

Volumn 89, Issue 3-4, 1983, Pages 217-228

  Croucher, Martin J ^a,b,c   Meldrum, Brian S ^a,b,c   Krogsgaard Larsen, Povl ^a,b,c  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Anticonvulsant drugs; Audiogenic seizures; Epilepsy; GABA uptake; Pentylenetetrazol seizure; Prodrugs; THPO Nipecotic acid

Indexed keywords

4 AMINOBUTYRIC ACID; 4 HYDROXYNIPECOTIC ACID; ANDROGEN; ANTICONVULSIVE AGENT; GABOXADOL; NIPECOTIC ACID; PENTETRAZOLE; PRODRUG;

4 HYDROXYNIPECOTIC ACID ETHYL ESTER; 4 HYDROXYNIPECOTIC ACID METHYL ESTER; ANIMAL MODEL; AUDIOGENIC SEIZURE; CENTRAL NERVOUS SYSTEM; DRUG EFFICACY; EPILEPSY; MOUSE; MUSCLE; MYOCLONUS; NIPECOTIC ACID ISOPROPYL ESTER; NIPECOTIC ACID PIVALOYLOXYMETHYL ESTER; NONHUMAN;

ACOUSTIC STIMULATION; ANIMAL; ANTICONVULSANTS; BODY TEMPERATURE; FEMALE; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; ISOXAZOLES; MALE; MICE; MICE, INBRED DBA; MOTOR ACTIVITY; NIPECOTIC ACIDS; PENTYLENETETRAZOLE; SEIZURES; SUPPORT, NON-U.S. GOV'T;

EID: 0020540528     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(83)90497-1     Document Type: Article

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