Oxidation of Trichloroethylene by Liver Microsomal Cytochrome P-450: Evidence for Chlorine Migration in a Transition State Not Involving Trichloroethylene Oxide

Biochemistry

Volumn 21, Issue 5, 1982, Pages 1090-1097

  Miller, Randall E ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE; CYTOCHROME P 450 ENZYME SYSTEM; CYTOCHROME P450; DRUG DERIVATIVE; TRICHLOROETHYLENE;

ANIMAL; ARTICLE; LIVER MICROSOME; MALE; METABOLISM; OXIDATION REDUCTION REACTION; RAT;

ANIMAL; CHLORINE; CYTOCHROME P-450 ENZYME SYSTEM; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; SUPPORT, U.S. GOV'T, P.H.S.; TRICHLOROETHYLENE;

EID: 0020473257     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00534a041     Document Type: Article

References (29)

1. Ahr, H.J., King, L.J., Nastainczyk, W., & Ullrich, V. (1980) Biochem. Pharmacol. 29, 2855–2861.
2. Banerjee, S., & Van Duuren, B.L. (1978) Cancer Res. 38, 776–780.
3. Barbin, A., Brésil, H., Croisy, A., Jacquignon, P., Malaveille, C., Montesano, R., & Bartsch, H. (1975) Biochem. Biophys. Res. Commun. 67, 596–603.
4. Bartsch, H., Malaveille, C., Barbin, A., & Planche, G. (1979) Arch. Toxicol. 41, 249–277.
5. Commins, B.T., & Lawther, P.J. (1965) Br. J. Ind. Med. 22, 139–143.
6. Daly, J.W., Jerina, D.M., & Witkop, B. (1972) Experientia 28, 1129–1149.
7. Defalque, R.J. (1961) Clin. Pharmacol. Ther. 2, 665–688.
8. Fieser, L.F., & Fieser, M. (1967) in Reagents for Organic Synthesis, p 330, Wiley, New York.
9. Gregory, N.W., & Thackrey, B.A. (1950) J. Am. Chem. Soc. 72, 3176–3178.
10. Groves, J.T., Kruper, W.J., Jr., & Haushalter, R.C. (1980) J. Am. Chem. Soc. 102, 6375–6377.
11. Guengerich, F.P., & Strickland, T.W. (1977) Mol. Pharmacol. 13, 993–1004.
12. Guengerich, F.P., & Martin, M. (1980) Arch. Biochem. Biophys. 205, 365–379.
13. Guengerich, F.P., Crawford, W.M., & Watanabe, P.G. (1979) Biochemistry 18, 5177–5182.
14. Henschler, D., Hoos, W.R., Fetz, H., Dallmeier, E., & Metzler, M. (1979) Biochem. Pharmacol. 28, 543–548.
15. Hess, B., & Wurster, B. (1970) FEBS Lett. 9, 73–77.
16. Kimmerle, G., & Eben, A. (1973) Arch. Toxikol. 30, 115–126.
17. Kline, S.A., & Van Duuren, B.L. (1977) J. Heterocycl. Chem. 14, 455–458.
18. Leibman, K.C. (1965) Mol. Pharmacol. 1, 239–246.
19. Lipmann, F., & Tuttle, L.C. (1945) J. Biol. Chem. 159, 21–28.
20. Mekhryushev, Yu. Ya., & Poluektov, V.A. (1973) Russ. J. Phys. Chem. (Engl. Transi.) 47, 959–960.
21. Miller, E.C., & Miller, J.A. (1981) Cancer (Philadelphia) 47, 2327–2345.
22. Morozowich, W., & Douglas, S.L. (1975) Prostaglandins 10, 19–40.
23. Ortiz de Montellano, P.R., Yost, G.S., Mico, B.A., Dinizo, S.E., Correia, M.A., & Kumbara, H. (1979) Arch. Biochem. Biophys. 197, 524–533.
24. Ortiz de Montellano, P.R., Beilan, H.S., Kunze, K.L., & Mico, B.A. (1981) J. Biol. Chem. 256, 4395–4399.
25. Powell, J.F. (1945) Br. J. Ind. Med. 2, 142–145.
26. Traylor, P.S., Nastainczyk, W., & Ullrich, V. (1976) Microsomes Drug Oxid., Proc. Int. Symp., 3rd, 615–621.
27. Tsukamoto, T., Suyama, K., Germann, P., & Sonenberg, M. (1980) Biochemistry 19, 918–924.
28. Van Duuren, B.L., & Banerjee, S. (1976) Cancer Res. 36, 2419–2422.
29. Wislocki, P.G., Miwa, G.T., & Lu, A.Y.H. (1980) Enzym. Basis Detoxication 1, 135–182.