Glucocorticoids inhibit precursor incorporation into protein in splenic lymphocytes by stimulating protein degradation and expanding intracellular amino acid pools

BBA - General Subjects

Volumn 717, Issue 2, 1982, Pages 236-247

  MacDonald, Richard G ^a   Cidlowski, John A ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

(Spleen lymphocyte); Amino acid incorporation; Amino acid pool; Glucocorticoid; Protein degradation

Indexed keywords

AMINO ACID; DEXAMETHASONE; LEUCINE; RADIOISOTOPE;

BLOOD AND HEMOPOIETIC SYSTEM; CELL SUSPENSION; DEXAMETHASONE H 3; DRUG MECHANISM; DRUG PROTEIN BINDING; IN VITRO STUDY; LEUCINE H 3; LYMPHATIC SYSTEM; LYMPHOCYTE; NONHUMAN; PROTEIN DEGRADATION; RAT; RNA SYNTHESIS; SPLEEN; SUCROSE C 14; URIDINE H 3;

AMINO ACIDS; ANIMAL; BIOLOGICAL TRANSPORT; CELL NUCLEUS; DEXAMETHASONE; KINETICS; LEUCINE; LYMPHOCYTES; POLYRIBOSOMES; PROTEINS; RATS; RECEPTORS, GLUCOCORTICOID; SPLEEN; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0020425552     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-4165(82)90175-1     Document Type: Article

References (32)

1. Effects of a single injection of cortisol on amino acid-incorporating activities of rat liver and thymic preparations in vitro.
2. Hormonal Steroids
3. THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS