The effects of spironolactone on reproductive functions in female rats and mice

Toxicology and Applied Pharmacology

Volumn 66, Issue 2, 1982, Pages 221-228

  Nagi, Salim ^a   Virgo, Bruce B ^a  

^a UNIVERSITY OF WINDSOR   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; ESTRADIOL; RADIOISOTOPE; SPIRONOLACTONE;

ANIMAL EXPERIMENT; DIESTRUS; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ENDOCRINE SYSTEM; ESTRADIOL H 3; ESTRUS; FEMALE; FEMALE GENITAL SYSTEM; FERTILITY; INFERTILITY; INTOXICATION; MOUSE; NONHUMAN; OVARY; OVULATION; PHARMACOKINETICS; PROGESTERONE C 14; PUBERTY; RAT; REPRODUCTION; TOXICITY; UTERUS;

ANIMAL; ESTRADIOL; ESTRUS; FEMALE; GONADORELIN; LITTER SIZE; MICE; MICE, INBRED STRAINS; OVARY; PREGNANCY; RATS; RATS, INBRED STRAINS; REPRODUCTION; SEX BEHAVIOR, ANIMAL; SEX HORMONES; SEX MATURATION; SPIRONOLACTONE;

EID: 0020422033     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/0041-008X(82)90286-1     Document Type: Article

References (34)

1. New data concerning the role played by progesterone in the control of follicular growth in the rat
2. Anti-androgenic effects of spironolactone in rats
3. Spironolactone therapy and gynecomastia
4. Induction of estrus in female mice: Estrogen-progesterone interactions
5. Suppression by the spironolactone metabolite canrenone of plasma testosterone in man
6. Relation of canrenone to the actions of spironolactone on adrenal cytochrome-P450-dependent enzymes
7. Investigation of the effect of methyltestosterone, cortisone and spironolactone on the hepatic microsomal mixed function oxidase system in male and female rats
8. A simplified procedure for the assay of progesterone
9. Blocking the renal electrolyte effects of mineralocorticoids with an orally active steroidal spironolactone
10. Michaelis constants for the hydroxylation of steroid hormones and drugs by rat liver microsomes
11. Spironolactone therapy and amenorrhea
12. Evidence for a preimplantation rise in oestradiol-17β levels on day 4 of pregnancy in the mouse
13. Spironolactaone and testicular cytochrome P450: Decreased testosterone formation in several species and changes in hepatic drug metabolism
14. Spironolactone and cytochrome P-450: Impairment of steroid 21-hydroxylation in the adrenal cortex
15. The effect of the administration of spironolactone on the concentration of plasma testosterone, estradiol and cortisol in male dogs
16. Studies on the destruction of adrenal and testicular cytochrome P450 by spironolactone
17. The use of Sephadex LH20 chromatography to separate unconjugated steroids
18. Plasma progesterone during pregnancy in the mouse
19. Interaction of spironolactone and digitalis with the 5 α-dihydrotestosterone (DHT) receptor of rat ventral prostate
20. Endocrinology of puberty
21. Interaction of digitalis and spironolactone with human sex steroid receptors
22. Oral progestational activity of spironolactone
23. Studies on the site of action of oral contraceptive steroids. Plasma LH and FSH levels after administration of antifertility steroids and LH-releasing hormone (LHRH)
24. Progesterone receptor in rat ovary
25. The estimation of glycogen with the anthrone reagent
26. Role of estrogen in the cerebral control of puberty in female rats
27. Effect of N-phenylbarbital (Plethabital) on the metabolism of testosterone and cortisol in man
28. Aldosteronism in hypertension: The spironolactone response test
29. Anti-adrogenic activity of spironolactone
30. The effect of spironolactone on drug metabolism by hepatic microsomes
31. Purification of the hyperglycemic-glycogenolytic factor from insulin and from gastric mucosa
32. 3H-digitoxigenin
33. Unilaterally ovariectomized pregnant mice: Dieldrin induction of the hepatic mono-oxygenases and plasma progesterone levels. Canad
34. Radioimmunoassay of plasma estrogens