메뉴 건너뛰기




Volumn 23, Issue 40, 1982, Pages 4147-4150

The synthesis of furan-based secoprostacyclins

Author keywords

[No Author keywords available]

Indexed keywords

NEW DRUG;

EID: 0020369426     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)88371-9     Document Type: Article
Times cited : (16)

References (9)
  • 4
    • 84914197473 scopus 로고    scopus 로고
    • All new compounds gave spectra (IR, NMR, MS) consistent with the assigned structure and satisfactory accurate mass measurement or combustion analysis.
  • 5
    • 84914197472 scopus 로고    scopus 로고
    • Similar results were obtained when either benzyl or tetrahydropyranyl was used as protecting group.
  • 6
    • 84914197471 scopus 로고    scopus 로고
    • 1-chloro-3-octanol, required in the synthesis of 19, was prepared by two alternative routes. The first involved sequential alkylation of 1,3-dithiane with 1-bromopentane and the tetrahydropyranyl ether of 2-bromoethanol followed by disulphurisation, chlorination and borohydride reduction of the ketone. This same intermediate was also available from acrolein by addition of hydrogen chloride followed by pentylation of the aldehyde with pentyl magnesium bromide.
  • 7
    • 0000744771 scopus 로고
    • During the course if this part of our programme we aware of the accidental synthesis of a close analogue of 6 by the Merck group - J. Medicin. Chem., 1978, 21, 1011.
    • (1962) Arch. Pharm. , vol.295 , pp. 627
    • Schulte1    Reisch2    Mock3
  • 9
    • 84914197470 scopus 로고    scopus 로고
    • All compounds were tested for thei ability to inhibit the aggregation of human platelets induced by ADP in platelet-rich plasma (Dr. M. Johnson)_and as diuretic agents (Dr. S.T. Kau) which involved oral dosing to salt-loaded male Wistar rats. No compound was sufficiently active to merit further study.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.