A Quantitative Structure-Activity Study of Anticonvulsant Benzyl N,N-Dimethylcarbamates

Chemical and Pharmaceutical Bulletin

Volumn 30, Issue 11, 1982, Pages 4175-4180

  Yamagami, Chisako ^a   Sonoda, Chihoko ^a   Takao, Narao ^a   Tanaka, Mitsuyo ^a   Yamada, Jun ^a   Horisaka, Kazuyoshi ^a   Fujita, Toshio ^b  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

anticonvulsant activity; benzylcarbamates; Hansch analysis; hydrogen bonding effect; optimum hydrophobicity; structure activity relationship; substituent electronic effect

Indexed keywords

N,N DIMETHYLCARBAMIC ACID BENZYL ESTER DERIVATIVE; NEW DRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CONVULSION; DOSE RESPONSE; DRUG ANALYSIS; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSHOCK SEIZURE; INFRARED SPECTROMETRY; INTRAPERITONEAL DRUG ADMINISTRATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; CARBAMATES; MALE; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0020350999     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.30.4175     Document Type: Article

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