Pharmacogenetics and the Fetus

New England Journal of Medicine

Volumn 307, Issue 2, 1982, Pages 115-116

  Spielberg, Stephen P ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CORTICOSTEROID; DNA; HYDANTOIN; PHENYTOIN;

BIRTH DEFECT; CONGENITAL DISORDER; CONGENITAL MALFORMATION; DRUG THERAPY; FETUS; HEREDITY; PHARMACOGENETICS; PREGNANCY; TERATOGENICITY; THERAPY;

ABNORMALITIES, DRUG-INDUCED; ANIMAL; FEMALE; FETUS; HUMAN; PHARMACOGENETICS; PREGNANCY;

EID: 0020317650     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198207083070210     Document Type: Editorial

References (11)

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2. Phelan M.C., Pellock J.M., Nance W.E. Discordant expression of fetal hydantoin syndrome in heteropaternal dizygotic twins. N Engl J Med. 1982; 307:99-101.
3. Goldman A.S., Katsumata M., Yaffe S.J., Gasser D.L. Palatal cytosol cortisol-binding protein associated with cleft palate susceptibility and H-2 genotype. Nature. 1977: 265:643-645
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5. Shum S., Jensen N.M., Nebert D.W. The murine Ah Locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism. Teratology. 1979; 20:365-376
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7. Spielberg S.P., Gordon G.B., Blake D.A., Goldstein D.A., Herlong H.F. Predisposition to phenytoin hepatotoxicity assessed in vitro. N Engl J Med. 1981; 305:722-727
8. Rao G.S., Wortel J.P. Gingival metabolism of phenytoin and covalent binding of its reactive metabolite to gingival proteins in the rat. In: Hassell TM, Johnston MC, Dudley KH, eds. Phenytoin-induced teratology and gingival pathology. New York: Raven Press, 1980: 189-98.
9. Gordon G.B., Spielberg S.P., Blake D.A., Balasubramanian V. Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite. Proc Natl Acad Sci USA. 1981; 78:2545-2548
10. Blake D.A. Requirements and limitations in reproductive and teratogenic risk assessment. In: Niebyl JR, ed. Drag use in pregnancy. Philadelphia: Lea & Febiger, 1982: 1-8.
11. Heinonen O.P., Slone D. Shapiro S. Birth defects and drugs in pregnancy. Littleton, Mass.: Publishing Sciences Group, 1977.