Thapsigargin and Thapsigargicin, Two Histamine Liberating Sesquiterpene Lactones from Thapsia garganica. X-ray Analysis of the 7,11-Epoxide of Thapsigargin

Journal of Organic Chemistry

Volumn 47, Issue 4, 1982, Pages 649-652

  Christensen, S Brøgger ^a   Larsen, I Kjøller ^a   Rasmussen, Ulla ^a   Christophersen, Carsten ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

THAPSIGARGIN;

DRUG ANALYSIS; DRUG ISOLATION; DRUG STRUCTURE; HIGHER PLANT; IN VITRO STUDY; METHODOLOGY; THAPSIA GARGANICA; THAPSIGARGICINE; THAPSIGARGINE 7,11 EPOXIDE; X RAY ANALYSIS;

EID: 0020079553     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo00343a009     Document Type: Article

References (14)

1. U. Rasmussen, “Farmakognostiske Undersøgelser af slaegten Thapsia L.”, Ph.D. Thesis, Royal Danish School of Pharmacy, Copenhagen, 1979.
2. U. Rasmussen, S. B. Christensen, and F. Sandberg, Acta Pharm. Suec. 15, 133 (1978)
3. S. A. Patkar, U. Rasmussen, and B. Diamant, Agents Actions 9, 53 (1979).
4. S. B. Christensen, U. Rasmussen, and C. Christophersen, Tetrahedron Lett., 21, 3829 (1980).
5. U. Rasmussen, S. B. Christensen, and F. Sandberg, Planta Med., in press.
6. K. H. Lee, E. S. Huang, C. Piantadosi, J. S. Pagano, and T. A. Geissman, Cancer Res., 31, 1649 (1971).
7. E. Rodriguez, G. H. N. Towers, and J. C. Mitchell, Phytochemistry, 15, 1573 (1976).
8. J. M. Cassady and M. Suffness in “Anticancer Agents Based on Natural Product Models”, J. M. Cassady and J. D. Douros, Ed., Academic Press, New York, 1980, p 201.
9. I. H. Hall, K. H. Lee, C. O. Starnes, Y. Sumida, R. Y. Wu, T. G. Wadell, J. W. Cochran, and K. G. Gerhart, J. Pharm. Sci., 68, 537 (1979).
10. I. H. Hall, C. O. Starnes, K. H. Lee, and T. G. Wadell, J. Pharm. Sci. 69, 537 (1980).
11. K. H. Lee, T. Ibuka, R. Y. Wu, and T. A. Geissman, Phytochemistry, 16, 1177 (1977).
12. N. Bernth, E. Larsen, and S. Larsen, Tetrahedron, 37, 2477 (1981).
13. P. Main, L. Lessinger, M. M. Woolfsen, G. Germain, J. P. Declercq, multan 77, University of York, England.
14. J. M. Stewart, P. A. Machin, C. Dickinson, H. L. Ammon, H. Heck, and H. Flack, “The x-ray 76 System”, Technical Report TR-446, Computer Science Center, University of Maryland, College Park, MD.