Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

Drug Development Research

Volumn 2, Issue 2, 1982, Pages 135-145

  Clineschmidt, Bradley V ^a   Martin, Gregory E ^a   Bunting, Patricia R ^a   Papp, Nan L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

amfonelic acid; amphetamine; Dibenzocyclokenimines; locomotor activity; methylphenidate; MK 801; rotational behavior

Indexed keywords

AMFONELIC ACID; AMPHETAMINE; CLOZAPINE; DIZOCILPINE; HALOPERIDOL; METHYLPHENIDATE; METIROSINE; OXIDOPAMINE; PRAZOSIN; RESERPINE;

10,11 DIHYDRO 5 METHYL 5H DIBENZO[A,D]CYCLOHEPT 5 EN 10 IMINE; ANIMAL EXPERIMENT; ANXIETY; BRAIN INJURY; CENTRAL NERVOUS SYSTEM; CIRCLING BEHAVIOR; CONVULSION; DRUG RESPONSE; LOCOMOTION; MOTOR ACTIVITY; MOUSE; MUSCULOSKELETAL SYSTEM; NIGROSTRIATUM; RAT;

EID: 0020078583     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.430020204     Document Type: Article

References (17)

1. Pharmacologic properties and mechanism of action of amfonelic acid
2. Pharmacologic studies with 7‐benzyl‐1‐ethyl‐1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acid
3. d‐Amphetamine‐induced release of “newly synthesized” and “stored” dopamine from the caudate nucleus in vivo
4. Blockade by reserpine of methylphenidate‐induced release of brain dopamine
5. 2‐receptors in the CNS: studies with mianserin
6. Stereospecific antidopaminergic and anticholinergic actions of the enantiomers of (±)‐1‐cyclopropylmethyl‐4‐(3‐trifluoromethylthio‐5H‐dibenzo[a,d]cyclohepten‐5‐ylidene)piperidine (CTC), a derivative of cyproheptadine
7. Anticonvulsant activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a,d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties
8. New tables for multiple comparisons with a control
9. Improved automated apparatus for recording rotation (circling behavior) in rats or mice
10. Amfonelic acid, a non‐amphetamine stimulant, has marked effects on brain dopamine metabolism but not noradrenaline metabolism: Association with differences in neuronal storage systems
11. Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamine in the brain
12. Actions of amfonelic acid and other non‐amphetamine stimulants on the dopamine neuron
13. Postsynaptic supersensitivity after 6‐hydroxydopamine‐induced degeneration of the nigrostriatal dopamine system
14. Amphetamine effects following inhibition of tyrosine hydroxylase