Evidence for the existence of distinct nitroreductases in salmonella typhimurium: Roles in mutagenesis

Carcinogenesis

Volumn 3, Issue 1, 1982, Pages 121-123

  Rosenkranz, E Joshua ^a,b   Mccoy, Elena C ^a,b   Mermelstein, Robert ^c   Rosenkranz, Herbert S ^a  

^a School of Medicine   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c XEROX CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; AMINOACRIDINE; NIRIDAZOLE; NITROREDUCTASE;

1,8 DINITROPYRENE; AMES TEST; ANIMAL EXPERIMENT; HEREDITY; IN VITRO STUDY; MUTAGENESIS; SALMONELLA TYPHIMURIUM;

MUTAGENS; NITRO COMPOUNDS; NITROREDUCTASES; OXIDOREDUCTASES; SALMONELLA TYPHIMURIUM; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0020044825     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/3.1.121     Document Type: Article

References (22)

1. Mermdstein, R., Rosenkranz, H.S., and McCoy, E.C. (1982), The microbial mutagenicity of nitroarenes, in R.Tice (ed.). The Genotoxic Effects of Agents, Brookhaven National Laboratory Symp. (R.Tice, ed.) in press.
2. Rosenkranz, H.S., and Mermelstein, R. (1980), The Saimoneila mutagenicity and the E. coli Pol A Pol A,-repair assays: evaluation of relevance to carcinogenesis in G.M.Williams, R.Kroes, H.W.Waaijers and K.W. Vande Poll, (eds.), Short-term Screening Tests in the Evaluation of Carcinogenicity, Elsevier/North Holland, pp. 5-26.
3. Mermelstein, R., Kiriazides, D.K., Butler, M., McCoy, E.C., and Rosenkranz, H.S. (1981), The extraordinary mutagenicity of nitropyrenes in bacteria, Mulal. Res., 89, 187-196.
4. LCfroth, G., Hefner, E., Alfheim, L, and Miller, M. (1980), Mutagenic activity in photocopies, Science (Wash.), 209, 1037-1039.
5. Tokiwa, H., Nakagawa, R., and Ohnishi, Y. (1981), Mutagenic assay of aromatic nitro compounds with Salmonella typhimurium, Mulal. Res., 91, 321-325.
6. National Academy of Sciences, U.S. (1981), Health effects of exposure to diesel exhaust, The Report of the Health Effects Panel of the Diesel Impact Study Committee, National Research Council, National Academy of Sciences, Washington, D.C.
7. McCoy, E.C., Rosenkranz, H.S., and Mermelstein, R. (1981), Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated pdycyclics to mutagens, Environ. Mutagenesis, 3, 421-427.
8. Rosenkranz, H.S., and Poirier, L.A. (1979), An evaluation of the mutagenicity and DNA modifying activity in microbial systems of carcinogens and non-carcinogens, J. Natl. Cancer Inst., 62, 873-892
9. Rosenkranz, H.S., McCoy, E.C., Sanders, D.R., Butler, M., Kiriazides, D.K., and Mermelstein, R. (1980), Nitropyrenes: isolation, identification and reduction of mutagenic impurities in a carbon black and toners, Science (Wash), 209, 1039-1043.
10. McCoy, E.C., Rosenkranz, E.J., Rosenkranz, H.S., and Mermelstein, R. (1981), Nitrated fluorene derivatives are potent frameshift mutagens, Mulal. Res., 90, 11-20.
11. McCoy, E.C., Rosenkranz, E.J., Petrullo, L.A., Rosenkranz, H.S., and Mermelstein, R. (1981), Structural basis of the mutagenicity in bacteria of nitrated naphthalene and derivatives, Environ. Mutagenesis, 3, 499-511.
12. Rosenkranz, H.S., McCoy, E.C., Mermelstein, R., and Speck, W.T. (1981), A cautionary note on the use of nitroreductase-deficient strains of Salmonella typhimurium for the detection of nitroarenes as mutagens in complex mixtures including Diesel exhausts, Mutat. Res., 91, 103-105.
13. Rosenkranz, H.S., Karpinsky, G.E., Anders, M., Rosenkranz, J.L.J., Petrullo, L.A., McCoy, E.C., and Mermelstein, R. (1982), Adaptability of microbial mutagenicity assays to the study of problems of environmental concern, in C.W. Lawrence, L. Prakash and F.Sherman (eds.), Induced Mutagenesis: Molecular Mechanisms and their Implications for Environmental Protection, Plenum Press, New York, in press.
14. McCoy, E.C., Rosenkranz, E.J., Petrullo, L.A., Rosenkranz, H.S., and Metmelstein, M. (1981), Frameshift mutations: Relative roles of simple intercalation and of adduct formation, Mutat. Res., 90, 21-30.
15. Ames, B.N., McCann, J., and Yamasaki, E. (1975), Methods for detecting carcinogens and mutagens with the Salmonella/mammaiian-microsome mutagenicity test, Mutat. Res., 31, 347-364.
16. Rosenkranz, H.S., and Speck, W.T. (1975), Mutagenicity of metronidazole: activation by mammalian liver microsomes, Btochem. Btophys. Res. Commun., 66, 520-525.
17. Speck, W.T., Bhimer, J.S., Rosenkranz, E.J., and Rosenkranz, J.-L.S. (1981), Niridazole nitroreductase deficiency in bacteria: an effect of genotype on mutagenicity of niridazole, Cancer Res., 41, 2305-2307.
18. McCoy, E.C., Petrullo, L.A., Rosenkranz, H.S., and Mermdstein, R. (1981), 4-Nitroquinoline-l-oxide: factors determining its mutagenicity in bacteria, Mutat. Res., 89, 151-159.
19. Campbell, J., Crumplin, G.C., Garner, J.V., Gamer, R.C., Martin, C.N., and Rutter, A. (1981), Nitrated polycyclic aromatic hydrocarbons: potent bacterial mutagens and stimulators of DNA repair synthesis in cultured human cells, Carcinogenesis, 2, 559-565.
20. McCoy, E.C., Anders, M., Rosenkranz, H.S., and Mermelstein, R. (1981), Absence of recombinogenic activity of nitropyrenes for yeast, in preparation.
21. McCalla, D.R., Reuvers, A., and Kaiser, C. (1970), Mode of action of nitrofurazone, J. Bacteriol., 78, 1126-1134.
22. Bryant, D.W., McCalla, D.R., Leeksma, M., and Laneuville, P. (1981), Type 1 nitroreductases of Escherichia colt, Can. J. Microbiol., 27, 81-86.