The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 319, Issue 3, 1982, Pages 197-205

  Magnan, Jacques ^a   Paterson, Stewart J ^a   Tavani, Alessandra ^a   Kosterlitz, Hans W ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

, , script Subtypes of opiate receptor; Agonist narcotic analgesics; Agonist antagonists; Antagonists; Guineapig ileum; Ketazocine like drugs; Mouse vas deferens; Rat vas deferens

Indexed keywords

BREMAZOCINE; CYCLAZOCINE; CYCLORPHAN; DIPRENORPHINE; ENKEPHALIN DERIVATIVE; ETHYLKETAZOCINE; ETORPHINE; FENTANYL; KETAZOCINE; LEVALLORPHAN; LEVORPHANOL; METAZOCINE; METHADONE; MORPHINE; N (TETRAHYDROFURFURYL)NORMETAZOCINE; NALORPHINE; NALOXONE; NALTREXONE; NORMORPHINE; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR; OXYMORPHONE; PENTAZOCINE; PETHIDINE; PHENAZOCINE; SUFENTANIL;

14BETA HYDROXY 17 (CYCLOPROPYLMETHYL)NORMORPHINE; 17 (CYCLOPROPYLMETHYL)NORMORPHINE; ANALGESIA; ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; DIHYDROMORPHINE H 3; DRUG BINDING; ENKEPHALIN[2 ALANINE 5 LEUCINE] H 3; ETHYLKETAZOCINE H 3; GUINEA PIG; HR 2766; ILEUM; IN VITRO STUDY; MALE GENITAL SYSTEM; MOUSE; NORMETAZOCINE DERIVATIVE; RAT; SMALL INTESTINE; VAS DEFERENS;

ANALGESICS, OPIOID; ANIMAL; BENZOMORPHANS; BINDING SITES; GUINEA PIGS; ILEUM; IN VITRO; MALE; MICE; NARCOTIC ANTAGONISTS; RATS; RECEPTORS, OPIOID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; VAS DEFERENS;

EID: 0019995533     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/BF00495865     Document Type: Article

References (45)

1. Mini symposium II. The in vivo differentiation of opiate receptors: Introduction
2. Some quantitative uses of drug antagonists
3. Dynorphin is a specific endogenous ligand of the ϰ opioid receptor
4. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic reaction
5. Mini symposium III. Simple in vivo tests that differentiate prototype agonists at opiate receptors
6. The effects of morphine-and nalorphinelike drugs in the nondependent and morphine-dependent and cyclazocine-dependent chronic spinal dog
7. Unexpected antagonism in the rat vas deferens by benzomorphans which are agonists in other pharmacological tests
8. Comparison of the binding characteristics of tritiated opiates and opioid peptides
9. Mini symposium IV. Discriminative stimulus effects of narcotics: evidence for multiple receptor-mediated actions
10. Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antagonist potencies of narcotic analgesics
11. Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey
12. Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone)
13. The morphine receptor in the guineapig ileum
14. In vitro models in the study of structure-activity relationships of narcotic analgesics
15. Characterization of opioid receptors in nervous tissues
16. Kosterlitz HW, Paterson SJ (1981) Tyr- d- Ala-Gly-MePhe-Gly-ol is a selective ligand for the μ-opiate binding site. Br J Pharmacol 73: 299P
17. Evidence at the cellular level for the presence of several opiate receptors
18. Rates of onset and offset of action of narcotic analgesics in isolated preparations
19. Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with μ- and δ-receptors
20. Morphine receptor in the myenteric plexus of the guinea-pig ileum
21. The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α- and β-adrenoceptors in the longitudinal muscle of the guinea-pig ileum
22. Kosterlitz HW, Magnan J, Paterson SJ, Tavani A (1981) Activity profiles of opiates at the μ-, δ- and ϰ-binding sites. Br J Pharmacol 74: 893P
23. Characterization of the ϰ-subtype of the opiate receptor in the guinea-pig brain
24. Assessment of the agonist and antagonist properties of narcotic analgesic drugs by their actions on the morphine receptor in the guinea-pig ileum
25. The assessment of agonist and antagonist properties of narcotic analgesic drugs by their actions on the morphine receptor in the guinea-pig ileum
26. Rat vas deferens: a specific bioassay for endogenous opioid peptides
27. Endogenous opioid peptides: multiple agonists and receptors
28. Opioid antagonists
29. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog
30. Tolerance to and physical dependence on N-allylnormetazocine (NANM) in chronic spinal dogs
31. Some 14 β-substituted analogue of N(cyclopropylamethyl)normorphine
32. A subclassification of ϰ-sites in the human brain by use of dynorphin 1–17
33. Phenylcyclidine (angle dust)/σ “opiate” receptor: visualization by tritiumsensitive film
34. Psychomimetic opioid binding: specific binding of [3H] SKF-10047 to etorphine-inaccessible sites in guinea-pig brain
35. Evaluation of new compounds for morphine-like physical dependence in the rhesus monkey
36. Evaluation of new compounds for morphine-like physical dependence in the rhesus monkey
37. Stereospecific increase by narcotic antagonists of evoked acetylcholine output in guinea-pig ileum
38. In vitro pharmacology of the opioid peptides, enkephalins and endorphins
39. Classification of multiple morphine and enkephalin binding sites in the central nervous system
40. Significance of physio-chemical properties of opiates for in vitro testing
41. The preference of putative proenkephalins for different types of opiate receptors
42. Opioid agonists and antagonists: Action on multiple opiate receptors
43. Opiates and enkephalins: a common binding site mediates their analgesic actions in rats
44. Demonstration of [3H] cyclazocine to multiple opiate receptor sites