Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

New England Journal of Medicine

Volumn 307, Issue 4, 1982, Pages 205-211

  Bristow, Michael R ^a   Ginsburg, Robert ^a   Minobe, Wayne ^a   Cubicciotti, Roger S ^a   Sageman, W Scott ^a   Lurie, Keith ^a   Billingham, Margaret E ^a   Harrison, Donald C ^a   Stinson, Edward B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CREATINE KINASE; DIGOXIN; DIHYDROALPRENOLOL H 3; DIURETIC AGENT; DRUG RECEPTOR; FLUORIDE; HISTAMINE; ISOPRENALINE; PROPRANOLOL; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONGESTIVE CARDIOMYOPATHY; ETIOLOGY; HEART; HEART CONTRACTION; HEART FAILURE; IN VITRO STUDY; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY;

ADENYLATE CYCLASE; ADOLESCENT; ADULT; CATECHOLAMINES; CONTRACTILE PROTEINS; CREATINE KINASE; DIHYDROALPRENOLOL; FEMALE; FLUORIDES; HEART FAILURE, CONGESTIVE; HISTAMINE; HUMANS; HYDROXYPROLINE; ISOPROTERENOL; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIUM; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC; RECEPTORS, ADRENERGIC, BETA; TRITIUM;

EID: 0019982539     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198207223070401     Document Type: Article

References (52)

1. Schwartz A., Sordahl L.A., Entman M.L., et al. Abnormal biochemistry in myocardial failure. Am J Cardiol. 1973; 32:407-422
2. Dhallas N.S., Das P.K., Sharma G.P. Subcellular basis of cardiac contractile failure. J Mol Cell Cardiol. 1978; 10:363-385
3. Braunwald E., Ross J. Jr., Sonnenblick E.H., eds. Mechanisms of contraction of the normal and failing heart. 2nd ed. Boston: Little, Brown. 1976: 309-56.
4. Epstein S.E., Skelton C.L., Levey G.S., Entman M. Adenyl cyclase and myocardial contractility. Ann Intern Med. 1970; 72:561-578
5. Watanabe A.M., Besch H.R. Cyclic adenosine monophosphate modulation of slow calcium influx channels in guinea pig hearts. Circ Res. 1974; 35:316-324
6. Spann J.F., Sonnenblick E.H., Cooper T., Chidsey C.A., Willman V.L., Braunwald E. Cardiac norepinephrine stores and the contractile state of heart muscle. Circ Res. 1966; 19:317-325
7. Harrison D.C. Effects of beta-blockade on circulatory dynamics. In: Braunwald E. ed. Beta-adrenergic blockade: a new era in cardiovascular medicine: proceedings of an international symposium. Amsterdam: Excerpta Medica, 1978: 59-73.
8. Gaffney T.E., Braunwald E. Importance of the adrenergic nervous system in the support of circulatory function in patients with congestive heart failure. Am J Med. 1963; 34:320-324
9. Epstein S.E., Braunwald E. The effect of beta adrenergic blockade on patterns of urinary sodium excretion: studies in normal subjects and in patients with heart disease. Ann Intern Med. 1966; 65:20-27
10. Nomenclature and criteria for diagnosis of diseases of the heart and blood vessels. New York: New York Heart Association. 1963.
11. Bristow M.R., Mason J.W., Billingham M.E., Daniels J.R. Dose-effect and structure function relationships in doxorubicin cardiomyopathy. Am Heart J. 1981; 102:709-718
12. Ross J. Jr., Braunwald E. The study of left ventricular function in man by increasing resistance to ventricular ejection with angiotensin. Circulation. 1964, 29:739-749
13. Parker J.O., West R.O., Ledwich J.R., DiGiorgi S. The effect of acute digitalization on the hemodynamic response to exercise in coronary artery disease. Circulation. 1969; 40:453-462
14. Thomas J.A., Marks B.H. Plasma norepinephrine in congestive heart failure. Am J Cardiol. 1978; 41:233-243
15. Colucci W.S., Alexander R.W., Williams G.H., et al. Decreased lymphocyte beta-adrenergic-receptor density in patients with heart failure and tolerance to the beta-adrenergic agonist pirbuterol. N Engl J Med. 1981; 305:185-190
16. Francis G.S., Goldsmith S.R., Ziesche S.M., Cohn J.N. Response of plasma norepinephrine and epinephrine to dynamic exercise in patients with congestive heart failure. Am J Cardiol. 1982; 49:1152-1156
17. Chidsey C.A., Braunwald E., Morrow A.G. Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failure. Am J Med. 1965; 39:442-451
18. Bito K., Kubo S., Saimyoji H. Role of endocrine factors in chronic congestive heart failure, with emphasis on catecholamines. Jpn Circ J. 1980; 44:117-127
19. Su Y.-F., Harden T.K., Perkins J.P. Catecholamine-specific desensitization of adenylate cyclase: evidence for a multistep process. J Biol Chem. 1980; 255:7410-7419
20. Bobik A., Campbell J.H., Carson V., Campbell G.R. Mechanism of isoprenaline-induced refractoriness of the β-adrenoreceptor-adenylate cyclase system in chick embryo cardiac cells. J Cardiovasc Pharmacol. 1981; 3:541-553
21. Mukherjee C., Caron M.G., Lefkowitz R.J. Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of β-adrenergic receptor binding sites. Proc Natl Acad Sci USA. 1975; 72:1945-1949
22. Mickey J.V., Tate R., Mullikin D., Lefkowitz R.J. Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro. Mol Pharmacol. 1976; 12:409-419
23. Stadel J.M., Lefkowitz R.J. Molecular mechanisms of β-adrenergic receptor desensitization. Proc West Pharmacol Soc. 1980; 23:469-475
24. Kent R.S., De Lean A., Lefkowitz R.J. A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. Mol Pharmacol. 1980; 17:14-23.
25. Marsh J.D., Barry W.H., NeerEJ. Alexander R.W., Smith T.W. Desensitization of chick embryo ventricle to the physiological and biochemical effects of isoproterenol: evidence for uncoupling of the β-receptor-adenylate cyclase complex. Circ Res. 1980; 47:493-501.
26. Tse J., Powell J.R., Baste C.A., et al. Isoproterenol-induced cardiac hypertrophy: modifications in characteristics of β-adrenergic receptor, adenylate cyclase, and ventricular contraction. Endocrinology. 1979; 105:246-255
27. Baumann G., Riess G., Erhardt W.D., et al. Impaired beta-adrenergic stimulation in the uninvolved ventricle post-acute myocardial infarction: reversible defect due to excessive circulating catecholamine-induced decline in number and affinity of beta-receptors. Am Heart J. 1981; 101:569-581
28. Goldstein R.E., Beiser G.D., Stampfer M., Epstein S.E. Impairment of autonomically mediated heart rate control in patients with cardiac dysfunction. Circ Res. 1975; 36:571-578
29. Karliner J.S., Barnes P., Brown M., Dollery C. Chronic heart failure in the guinea pig increases cardiac α1- and β-adrenoceptors. Eur J Pharmacol. 1980; 67:115-118
30. Brodde O.-E., Engel G., Hoyer D., Bock K.D., Weber F. The β-adrenergic receptor in human lymphocytes: subclassification by the use of a new radioligand. (±)-125iodocyanopindolol. Life Sci. 1981; 29:2189-2198
31. Ginsburg R., Bristow M.R., Stinson E.B., Harrison D.C. Histamine receptors in the human heart. Life Sci. 1980; 26:2245-2249
32. Billingham M.E., Baumgartner W.A., Watson D.C., Reitz B.A., et al. Distant heart procurement for human transplantation: ultrastructural studies. Circulation. 1980; 62: Suppl 1:I-11-9.
33. Williams L.T., Lefkowitz R.J., Receptor binding studies in adrenergic pharmacology. New York: Raven Press, 1978.
34. Mukherjee C., Caron M.G., Coverstone M., Lefkowitz R.J. Identification of adenylate cyclase-coupled β-adrenergic receptors in frog erythrocytes with (-)-[3H]alprenolol. J Biol Chem. 1975; 250:4869-4876
35. Baker S.P., Boyd H.M., Potter L.T. Distribution and function of β-adrenoceptors in different chambers of the canine heart. Br J Pharmacol. 1980; 68:57-63.
36. Scatchard G. The attractions of proteins for small molecules and ions. Ann NY Acad Sci. 1949; 51:660-672
37. Bristow M.R., Cubicciotti R., Ginsburg R., Stinson E.B., Johnson C. Histamine-mediated adenylate cyclase stimulation in human myocardium. Mol Pharmacol. 1982; 21:671-679
38. Salomon Y., Londos C., Rodbell M. A highly sensitive adenylate cyclase assay. Anal Biochem. 1974; 58:541-548
39. Johnson C.L., Weinstein H., Green J.P. Studies on histamine H2 receptors coupled to cardiac adenylate cyclase: blockade by H2 and H1 receptor antagonists. Mol Pharmacol. 1979; 16:417-428
40. Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology (SCE). Recommended method for the determination of creatine kinase in blood modified by the inclusion of EDTA. Scand J Clin Lab Invest. 1979; 39:1-5.
41. Giovanna F.A. Resolution of bacterial proteins by polyacrylamide gel electrophoresis on slabs: membrane, soluble, and periplasmic fractions. J Biol Chem. 1974; 249:634-644
42. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193:265-275
43. Prockop D.J., Udenfriend S. A specific method for the analysis of hydroxyproline in tissues and urine. Anal Biochem. 1960; 1:228-239
44. Wallenstein S., Zucker C.L., Fleiss J.L. Some statistical methods useful in circulation research. Circ Res. 1980; 47:1-9.
45. Frederiksen D.W., Hoffnung J.M., Frederiksen R.T., Williams R.B. The structural proteins of normal and diseased human myocardium. Circ Res. 1978; 42:459-466
46. Drummond G.I., Severson D.L., Duncan L. Adenyl cyclase: kinetic properties and nature of fluoride and hormone stimulation. J Biol Chem. 1971; 246:4166-4173
47. Ginsburg R., Bristow M.R., Billingham M.E., Stinson E.B., Schroeder J.S., Harrison D.C. A study of the normal and failing isolated human heart: decreased response of failing heart to isoproterenol. Am Heart J. (in press).
48. Limbird L.E. Activation and attenuation of adenylate cyclase: the role of GTP-binding proteins as macromolecular messengers in receptor-cyclase coupling. Biochem J. 1981; 195:1-13.
49. Nickerson M. Receptor occupancy and tissue response. Nature. 1956; 178:697-698
50. Stephenson R.P. A modification of receptor theory. Br J Pharmacol Chemother. 1956; 11:379-393
51. Johnson G.L., Bourne H.R., Gleason M.K., et al. Isolation and characterization of S49 lymphoma cells deficient in β-adrenergic receptors: relation of receptor number to activation of adenylate cyclase. Mol Pharmacol. 1978; 15:16-27.
52. Venter J.C. High efficiency coupling between beta-adrenergic receptors and cardiac contractility: direct evidence for “spare” beta-adrenergic receptors. Mol Pharmacol. 1979; 16:429-440