Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs

Neuropharmacology

Volumn 21, Issue 8, 1982, Pages 803-810

  Loscher W ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

GABAmimetic drugs; mice; seizure thresholds; toxicity

Indexed keywords

4 AMINO 5 HEXYNOIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID CETYL ESTER; AMINOOXYACETIC ACID; ANTICONVULSIVE AGENT; ATROPINE; ETHANOLAMINE SULFATE; GABACULINE; GABOXADOL; GUVACOLINE; MUSCIMOL; PENTETRAZOLE; PROGABIDE; VALPROIC ACID; VIGABATRIN;

ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CONVULSION; DRUG ADMINISTRATION; DRUG ANALYSIS; DRUG COMPARISON; DRUG RESPONSE; DRUG TOXICITY; GUVACINE ETHYL ESTER; INTOXICATION; MIMETIC AGENT; MOUSE; NIPECOTIC ACID ETHYL ESTER; NIPECOTIC ACID METHYL ESTER; SEIZURE;

ANIMAL; ANTICONVULSANTS; COMPARATIVE STUDY; ELECTROSHOCK; GAMMA-AMINOBUTYRIC ACID; LETHAL DOSE 50; MALE; MICE; PENTYLENETETRAZOLE; SUPPORT, NON-U.S. GOV'T;

EID: 0019979320     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(82)90068-5     Document Type: Article

References (36)

1. Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures
2. On the mode of action of SL 76002, a new GABA receptor agonist
3. Une nouvelle méthode simple pour explorer l'action “tranquillisante” le test de la cheminée
4. A note on a simple apparatus for detecting neurological deficit in rats and mice
5. Cetyl GABA: Effect on convulsant thresholds in mice and acute toxicity
6. Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice
7. A simple intravenous infusion technique for mice
8. In vivo biochemistry of GABA transaminase inhibition
9. The effect of sodium-n-dipropyl acetate on γ-aminobutyric acid-dependent inhibition in the rat cortex and substantia nigra in relation to its anticonvulsant activity
10. Chemical protection against ionizing radiation
11. Inhibitors of the GABA uptake systems
12. GABA uptake inhibitors as experimental tools and potential drugs in epilepsy research
13. A simplified method of evaluating dose-effect experiments
14. Pharmacological profile of SL 76002, a new GABA-mimetic drug
15. Biochemical evidence for the alterations of GABA-mediated synaptic transmission in pathological brain tissue (stereo EEG or morphological definition from epileptic patients
16. A comparative study of the pharmacology of inhibitors of GABA-metabolism
17. Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake and metabolism of GABA
18. Zum Wirkungsmechanismus der Antiepileptika. Tierexperimentelle Befunde zur Bedeutung von Neurotransmittern
19. Valproate induced changes in GABA metabolism at the subcellular level
20. Biochemical pharmacology of inhibitors of GABA-metabolism and valproic acid
21. Relationship between drug-induced changes in seizure thresholds and the GABA content of brain and brain nerve endings
22. Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice
23. Aminooxyacetic acid Correlation between biochemical effects anticonvulsant action and toxicity in mice
24. GABA in cerebrospinal fluid of children with frebrile convulsions
25. Convulsant drugs, anticonvulsants and GABA-mediated neuronal inhibition
26. Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy
27. Inhibitors of GABA metabolism
28. The pharmacology of GABA-transaminase inhibitors
29. Failure of aminooxyacetic acid therapy in Huntington's disease
30. Effect of sodium n-dipropylacetate on audiogenic seizures and brain γ-aminobutyric acid level
31. Electrically induced convulsions
32. Comparative assays of antiepileptic drugs in mice and rats
33. Effects of GAD and GABA-T inhibitors on GABA metabolism in vivo
34. Low cerebrospinal fluid γ-aminobutyric acid content in seizure patients
35. Applications to drug evaluations
36. Functional alterations of GABA synapses in relation to seizures