The partial protective effect of the hydroxyl radical scavenger dimethyl urea on streptozotocin-induced diabetes in the mouse in vivo and in vitro

Diabetologia

Volumn 23, Issue 4, 1982, Pages 374-378

  Sandler, S ^a   Andersson, A ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

C57BL KsJ mice; dimethyl urea; insulitis; NMRI mice; proinsulin biosynthesis; Streptozotocin

Indexed keywords

DIMETHYLUREA; INSULIN; PROINSULIN; PROTECTIVE AGENT; STREPTOZOCIN;

ANIMAL EXPERIMENT; DIABETES MELLITUS; ENDOCRINE SYSTEM; INSULITIS; MOUSE;

ANIMAL; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FREE RADICALS; HYDROXIDES; HYDROXYL RADICAL; IN VITRO; ISLETS OF LANGERHANS; MALE; METHYLUREA COMPOUNDS; MICE; MICE, INBRED C57BL; PANCREAS; PROINSULIN; STREPTOZOCIN; SUPPORT, NON-U.S. GOV'T;

EID: 0019968492     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00253747     Document Type: Article

References (32)

1. The biology of oxygen radicals
2. The generation of hydrogen peroxide, superoxide radical and hydroxyl radicals by 6-hydroxy-dopamine, dialuric acid and related cytotoxic agents
3. Alloxan-induced diabetes — Evidence for hydroxyl radical as a cytotoxic intermediate
4. Protection against alloxan-induced diabetes in mice by the hydroxyl radical scavenger dimethylurea
5. Protection against alloxan-induced diabetes by various urea derivates: Relationship between protective effects and reactivity with the hydroxyl radical
6. Superoxide dismutase, catalase and scavengers of hydroxyl radicals protect against the toxic action of alloxan on pancreatic islet cells in vitro
7. Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase and a metal chelator
8. Dimethylurea: A radical scavenger that protects isolated pancreatic islets from the effects of alloxan and dihydroxyfumarate exposure
9. Mechanism for chemically induced diabetes: Evidence for oxidant action and free radical production
10. Protection against streptozotocin-induced diabetes by superoxide dismutase
11. Polyethyleneglycol-superoxide (PEG-SOD) protect against streptozotocin-induced diabetes in mice
12. Diabetes induced with multiple subdiabetogenic doses of streptozotocin. Lack of production by exogenous superoxide dismutase
13. The role of cryoprotective agents as hydroxyl radical scavengers
14. Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitro
15. Untersuchungen über die Harnstoffbildung im Tieferkörper
16. Anti-insulin serum coupled to Sepharose 4B as a tool for the investigation of insulin biosynthesis in the B-cells of obese hyperglycemic mice
17. Islet implantation into mice with pancreatic insulitis
18. On the protection against alloxan diabetes by hexoses
19. On the mechanism of glucose protection against alloxan toxicity
20. Streptozotocin diabetes in the mouse and guinea pig
21. Studies on the ability of compounds to block the diabetogenic activity of streptozotocin
22. Studies on streptozotocin diabetes
23. Genetic influence of the streptozotocin-induced insulitis and hyperglycemia
24. Viral studies in streptozotocin-induced pancreatic insulitis
25. Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of background, sex and thymus
26. Protection by picolinamide, a novel inhibitor of poly(ADP-ribose)synthetase, against both streptozotocin induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets
27. Pyridine nucleotide depletion in pancreatic islets associated with streptozotocin-induced diabetes
28. Streptozotocin diabetes: Further studies on the mechanism of depression of nicotinamide adenine dinucleotide concentrations in mouse pancreatic islets and liver
29. DNA strand scission by enzymically generated oxygen radicals
30. The involvement of poly(ADP-ribose)polymerase in the degradation of NAD caused by γ-radiation and Nmethyl-N-nitrosourea